Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of this study was to evaluate morphologically the cerebroprotective effect of lanthanum acetate in chronic cerebral ischemia. Chronic cerebral ischemia was reproduced in Wistar rats, weighing 160-180 g, by a ligation of both common carotid arteries. For corection of ischemic cerebral damage, lanthanum acetate (3 mg/kg of body weight, once a day) was introduced intragastrically during the whole experimental period. Ischemic damage of the cerebral cortex was evaluated morphologically in Nissl stained histological sections. Lanthanum acetate was found to suppress the development of ischemia-induced neuronal damage in cerebral hemispheres: the numbers of hyperchromatic neurons, cells with focal chromatolysis, and ghost cells were reduced, while the number of normochromatic neurons was increased in experimental group as compared to those in controls.
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PMID:[Morphological evaluation of cerebroprotective effect of lanthanum acetate in chronic cerebral ischemia in rats]. 1796 23

The aim of the present work was to perform a morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. Chronic ischemia was produced in Wistar rats (weighing 160-180 g) by ligation of both common carotid arteries. Ischemic lesions were corrected by intragastric lanthanum acetate (3 mg/kg per day) throughout the experimental period. Ischemic damage to the cortex was assessed morphometrically on histological sections stained by the Nissl method. Lanthanum acetate was found to suppress the development of ischemic neuron damage in the cerebral cortex, with reductions in the numbers of hyperchromic neurons, cells with focal chromatolysis, and ghost cells, as well as an increase in the number of normochromic cells as compared with controls.
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PMID:Morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. 1870 58