Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022116 (
ischemia
)
91,303
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
"Tianma" (
Gastrodia
) and "gouteng" (
Uncaria
) are both widely used to treat cerebral ischemia. At the same time, "ezhu" (
Curcuma
longa
) or turmeric, is derived from the dried roots of
C. longa
. It is a polyphenol known for its anti-inflammatory effects and its promotion of blood vessel endothelial function. This study explored the neuroprotective effects of a water extract of "tianma", "gouteng", and "ezhu" against ischemic injury. Flow cytometry analysis showed that
Gastrodia
,
Uncaria
, and
Curcuma
reduced the proportion of apoptotic cells in CoCl
2
induced B35 (
P
= 0.0027) and SH-SY5Y (
P
= 0.0006) cell sample relative to the respective control group. Western blot indicated that
Gastrodia
,
Uncaria
, and
Curcuma
upregulated the expression of Bcl-2 and inversely downregulated Bax and Caspase-3 (
P
< 0.001). The infarct volume observed in the
Gastrodia
,
Uncaria
, and
Curcuma
group was also decreased compared with the control group (
P <
0.05). Immunofluorescence detection revealed a lower expression of Caspase-7 in the
Gastrodia
,
Uncaria
, and
Curcuma
group than in the control group, while expression was negligible in the sham group.
Gastrodia
,
Uncaria
, and
Curcuma
confer neuroprotective effects in CoCl
2
induced B35/SH-SY5Y cells and a rat model of
ischemia
by way of its anti-apoptotic effects.
...
PMID:Herbal decoction of
Gastrodia
,
Uncaria
, and
Curcuma
confers neuroprotection against cerebral ischemia
in vitro
and
in vivo
. 3307 May 32
<< Previous
1
2
3
4
5
6
7
