Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A protective effect of metipranolol on renal ischemia has recently been demonstrated in our laboratory. The aim of present work was to investigate the effect of this drug on a model of total hepatic ischemia. Inosine was chosen as a comparative agent. Metipranolol (1 mg.kg-1) or inosine (160 mg.kg-1) were given i.v. to rats 15 min prior to inducing of 30-min lasting hepatic ischemia. The animals were followed up for 90 min after the end of ischemia. Pretreatment with inosine almost removed the harmful effect of ischemia on bile flow. Pretreatment with metipranolol slightly minimized the post-ischemic bile flow fall, this effect having been statistically significant only at 30. min of postischemic period. Neither inosine, nor metipranolol administration influenced significantly the ALT or AST plasma activity 90 min after release of hepatic vessels occlusion.
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PMID:The effect of metipranolol and inosine on total hepatic ischemia of rats in vivo. 790 75

D,L-propranolol protects kidney against warm ischemia. On the contrary beta-blockers without membrane stabilizing activity (timolol, L-propranolol) do not possess this protective ability. The aim of the present work was to test the potential anti-ischemic properties of metipranolol, another beta-blocker with membrane stabilizing component. Metipranolol (1 mg/kg) was given 30 min prior to inducing the ischemia of left rat kidney followed with a contralateral nephrectomy. This pretreatment lowered the creatinemia as measured 24 hr after 60 min ischemia and improved the survival of rats after 90 min renal ischemia. The results are compatible with the concept that the membrane stabilizing activity may play a crucial role in the protective action of beta-blockers.
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PMID:A beneficial effect of metipranolol pretreatment on rat kidney ischemia in vivo. 790 76