Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, vascular dementia (VD, 31 cases), senile dementia of Alzheimer type (DAT, 36 cases) and mixed type dementia (14 cases) were studied by means of magnetic resonance imaging (MRI). Diagnosis of dementia was made according to DSM-III and Hachinski's ischemic score. The areas of periventricular high intensity lesions (PVH) and those of brain parenchyma were measured by digitizer which was connected to a computer. The PVH score was obtained by dividing the areas of PVH by those of brain parenchyma at the level of the body of the lateral ventricule. A multiple variable analysis was applied to the PVH scores and risk factors for dementia using Hayashi's quantification method I. The multiple correlation coefficient between the PVH and the risk factors was 0.685. The most significant correlation was found between Hachinski's ischemic score and the PVH score (partial correlation coefficient: 0.58). Significant correlations were also found between ADL and the PVH score (0.25), as well as between the Hasegawa dementia score and the PVH score (0.24). Using the student T test, it was shown that the large PVH group was significantly correlated to poor ADL, whereas the small PVH group was not. The large PVH group in VD showed lower Hasegawa score than the small PVH group. On the other hand, there was no such correlation in DAT. PVH with prolongation of T2 could exist in various pathological states irrespective of their causes. Diffuse PVH tended to be frequently observed in VD together with poor ADL. It was therefore thought that brain ischemia was the main cause of PVH.
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PMID:[Clinical significance of periventricular high intensity lesions on magnetic resonance imaging in dementia]. 206 92

To investigate the relationship between troublesome behavior and cognitive status in Alzheimer type dementia (DAT), and to know whether the addition of cerebrovascular ischemia modifies that relationship, we studied behavioral and cognitive data from a clinical series of 57 DAT patients (mean age: 83.4 yrs) and 31 patients with mixed Alzheimer and vascular dementia (MIX) (mean age: 83.4 yrs). All subjects were ambulatory and were recruited from among patients having been admitted to our affiliated nursing home. None of them had any serious systemic diseases. The Dementia Behavior Disturbance scale (DBD), originally developed by Baumgarten et al, and the Mini-Mental State (MMS) were used for the evaluation of behavioral problems and cognitive status, respectively. In the DAT group, a significant correlation was recognized between DBD and MMS scores. In the MIX group, however, DBD scores did not correlate with MMS scores. Among patients having MMS scores greater or equal to 20, those with MIX had higher DBD scores (mean 19.3) than those with DAT (mean 13.7), although MMS scores in these two subgroups were comparable. These findings suggest that in DAT, behavioral problems increase in conjunction with cognitive impairments. However, with the addition of cerebrovascular ischemia to Alzheimer pathology, behavioral impairments may progress independently of cognitive decline, with more frequent presentation of troublesome behaviors in the early stage of dementia.
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PMID:[Relationship between behavioral problems and cognitive status in Alzheimer type and mixed Alzheimer and vascular dementia]. 772 88