Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We measured plasma endothelin-1 (ET) in 10 patients undergoing coronary artery bypass grafting under high dose fentanyl (107.0 +/- 11.9 micrograms.kg-1, mean +/- SD) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) just before the start of cardiopulmonary bypass (CPB), and 3) just before the end of CPB. ET levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension. ET concentrations in period 1, 2, and 3 were 1.8 +/- 0.7, 3.4 +/- 1.1 and 3.1 +/- 1.3 pg.ml-1 (mean +/- SD), respectively. There were significant differences between the control value and the values obtained at periods 2 and 3 (P less than 0.05). The elevation in ET level before CPB suggests the existence of hidden coronary ischemia despite the absence of detectable sign indicating myocardial oxygen supply demand imbalance. It was also suggested that, under high dose fentanyl anesthesia, stress evoked by CPB might not affect plasma ET concentration.
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PMID:[Changes in endothelin in plasma in patients undergoing coronary artery bypass grafting under high dose fentanyl anesthesia]. 156 May 78

Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.
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PMID:Passive and active target delivery of drugs to ischemic myocardium. 2280 53