Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022116 (
ischemia
)
91,303
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Indeloxazine hydrochloride
(
Indeloxazine
) has been known as a new type drug with enhancing effects on memory and learning processes in various experimental models. In the present studies, effects of
Indeloxazine
on brain energy and glucose metabolisms were determined in four-vessel occlusion rat model. Since a critical point of ischemic time for the recovery of brain energy levels existed between 30 min and 60 min in this model, effects of
Indeloxazine
were determined in the rat model of 60 min recirculation following 60 min
ischemia
. One-week dosing of
Indeloxazine
at 2 mg/kg showed slight increases in ATP and total adenine nucleotides levels. To elucidate the mechanism of improving action of
Indeloxazine
on brain energy levels, effects on glucose metabolism were determined. Non-treated group of 60 min
ischemia
-60 min recirculation showed severe reduction of 14C-2-deoxyglucose metabolism in comparison to normal control group.
Indeloxazine
-treated group showed a slight improvement of 14C-2-deoxyglucose metabolism in comparison to non-treated group. Furthermore, high 14C-2-deoxyglucose metabolism was observed in parts of hippocampus, cortex and thalamus. From these results, it seems possible that
Indeloxazine
has some protective effects on brain damage in four-vessel occlusion rat model.
...
PMID:[Effects of indeloxazine hydrochloride on brain energy and glucose metabolism in the four-vessel occlusion rat model]. 371 83
