Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatic ischemia hinders the proliferative response of hepatocytes, necessary to restore the liver/body ratio after liver resection/transplantation. Folinic acid administered during the ischemic period following 70% hepatectomy plus 15 min of normothermic liver ischemia has restored the regenerative response to the levels of normoperfused livers. This unexpected finding has guided us to design the present study in order to find out whether the folinic acid is an hepatotrophic substance or not. Sprague-Dawley rats submitted to partial (40 or 70%) hepatectomies were used. Saline (2 cc) or folinic acid (2.5 mg/kg) have been administered i.v. Forty-eight hours after hepatectomy the hepatocyte's DNA content has been assessed by means of a cytophotometric technique, and the percentage of regenerating hepatocytes (PRH) has been calculated. Folinic acid administration has significantly increased the PRH in both resting (5.1 vs 1.2) and regenerating livers (70% hepatectomy) (22.2 vs 41) when compared with nontreated groups. Folinic acid administration after liver ischemia plus hepatectomy has shown similar results, corroborating our previous study. Although its mechanisms of augmentation of liver regeneration remain unclear and further studies are required, folinic acid seems to be a promising therapeutic tool in liver surgery.
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PMID:Hepatotrophic effect of folinic acid in rats. 865 37

The case review describes a case of a patient, hospitalized with T3N0M1 carcinoma of the splenic flexure, with multiple metastases in the both liver lobes. The patient underwent left-sided hemicolectomy with cholecystectomy. Having considered the inoperable liver findings, a chemoport was implanted. The patient underwent 10 chemotherapy cycles with no major complications recorded. The chemotherapy cycle included Campto, Leucovorin, 5FU and, concomittantly, 5FU as a continual 22-hour infusion into the port. After completion of the Cycle 10, the ultrasound and CT findings showed marked regression of the metastases, by half to two thirds. Following consultation at the onco-surgical seminar, extended left-sided hemihepatectomy was performed. The procedure lasted 6 hours, the blood loss was 3.500 ml, the period of warm ischemia was 8 minutes. Based on the oncologists' recommendation, the chemoport was preserved. The latest abdominal ultrasound detected no focal liver changes, a hypechogenic to unechogenic septed formation, v.s. a postoperative hematoma, was detected near the medial liver margin. Based on the conclusion of the oncological assessment, the patient was indicated for adjuvant chemotherapy, containing the same agents, for a period of 2-3 months. The aim of this report is to present a case of downstaging of the originally inoperable finding of the liver metastases.
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PMID:[An example of the liver metastases downstaging following chemoport implantation]. 1845 43