Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electric shock-induced myocardial infarction is rare. Shock-induced coronary artery thrombosis and dissection in multiple distributions have not been reported. After shock, coronary thrombosis may cause anginal symptoms, and any coronary artery may be damaged. A 32-year-old man presented with angina and ischemia-related symptoms after 6,000-V electric shock. He reported occasional exertional angina; the stress echocardiography result was positive for ischemia. Cardiac catheterization showed severe multivessel disease, an occluded left anterior descending coronary artery, and an occluded circumflex artery with collateralization to the distal left anterior descending coronary artery. Surgical intervention detected global coronary dissection and thrombosis. Bypass grafting achieved complete revascularization. The patient was successfully discharged home.
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PMID:Electric Shock-Induced Coronary Artery Thrombosis and Dissection. 3002 78

Myocardial bridging (MB)-a congenital coronary abnormality in its severe form leads to myocardial edema, fibrosis, and ischemia due to coronary artery compression during systole and early part of the diastole. This study evaluated the hemodynamic significance of MB by detecting severity and extent of perfusion abnormality using 99mTc-sestamibi (MIBI) gated single photon emission computed tomography (SPECT)/CT myocardial perfusion imaging (MPI), its correlation with coronary angiography and role in patient's management. Five patients with complaints of atypical chest pain, exertional angina, or dyspnea underwent stress/rest 99mTc-MIBI SPECT/CT MPI. The gated stress and rest SPECT/CT images on 17 segment model using quantitative gated-SPECT (QGS) softwarewere analyzed and compared with coronary angiography. Four out of five patients showed reversible perfusion defect in the left anterior descending (LAD) territory segments involved with myocardial bridging (3 patients had already proven MB; while MB was detected in 1 patient after MPI). The fifth patient with MB in the distal LAD revealed normal myocardial perfusion. All the patients were conservatively managed either due to small reversible perfusion defects or normal study except one patient. The gated SPECT/CT MPI of five patients with MB in the present study revealed their perfusion status, information on myocardial wall thickening, contractility, and ejection fraction. <Learning objective: Myocardial bridging may be one of the underlying causes for angina or sudden death even in absence of cardiovascular risk factors. The proven or clinical suspicious myocardial bridging in patients with typical/atypical chest pain and low probability of atherosclerosis should be evaluated with gated SPECT/CTMPI. It helps in detection of coronary artery disease along with severity and extent of myocardial ischemia for their further management.>.
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PMID:Role of 99mTc-sestamibi gated SPECT/CT myocardial perfusion imaging in the management of patients with myocardial bridging and its correlation with coronary angiography. 3027 61

The prevalence of congenital coronary artery anomalies is approximately 1% in the general population. They are a common cause of sudden death in younger persons. Congenital absence of the left circumflex artery is usually a benign condition but can cause symptoms of exertional angina. We present a case of a 59-year-old female who presented with complaints of chest pain. She was evaluated by the cardiology service. An invasive angiogram identified the absence of the circumflex artery, a large right coronary artery, and large septal and diagonal branches of the left main coronary artery possibly as a compensatory mechanism to supply blood to the LCx territories. It is important to define coronary anatomy as anomalies dictate which cardiac intervention should be attempted in cases of ischemia.
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PMID:Congenital anomaly of coronary artery: absence of left circumflex artery. 3104 45


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