Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results of subarachnoid hemorrhage (SAH) in the acute phase are represented by the direct threat of vasospasm. The first step still is to recognise SAH, so that all misleading clinical aspects of arterial aneurysm rupture do not misguide, or even fail to do the right diagnosis. If so, rebleeding still remains a real danger. Among biological patterns, hyponatremia is an important factor of vasospasm. Cardiovascular symptoms are represented by a sudden and transient arterial hypertension which can drive to a diagnostic error and electrocardiographic abnormalities, which are directly related with the degree of vasospasm; their evolution is completely regressive. Main intracranial consequences are early hydrocephalus, worsening of consciousness and progressive ventricular distension on CT scan and vasospasm, which occurs between the 4th and the 12th day, may be asymptomatic or symptomatic, responsive for delayed ischemia, followed by deterioration of consciousness and focal neurological signs. The main factors responsible for the vasospasm are a high amount of blood in basal cisterns on CT scan; an increase of substances released by the lysis of hemoglobin in CSF; hyponatremia, hypovolemia, and decrease in cerebral blood flow. Consequences of these disorders have to be well known in the medical treatment before and after operation.
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PMID:[Consequences of meningeal hemorrhage during the first days after its onset]. 228 34

Treatment with an anticoagulant (AC) or acetylsalicylic acid (ASA), chosen at random, was given to 241 patients with symptoms of carotid transient attacks of ischemia, some of whom recovered completely within 24 hours (TIA) while the others had slight residual symptoms (TIA-IR). Cerebral infarction was recorded in 4 patients in each of these treatment groups during a mean follow-up period of 20 months. The incidences of TIA and TIA-IR were also similar in the two groups. Severe hemorrhage occurred more often in the AC group, whereas other side reactions, including gastrointestinal disorders, were more common in the ASA group. Recurrent cerebral ischemic events were significantly more common among the patients that had had greater than or equal to 2 TIAs in the 14 days immediately preceding randomization, and in those with a history of CVS symptoms more than 14 days before randomization, or those with a carotid bruits. In the group experiencing greater than or equal to 2 TIAs in the 14 days prior to randomization the incidence of recurrent cerebral ischemic events was the same for the two types of treatment.
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PMID:Treatment after transient ischemic attacks: a comparison between anticoagulant drug and inhibition of platelet aggregation. 665 49