Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We performed three sets of experiments to investigate the safety of intrathecal magnesium and to determine its optimal dose for protection, if any, against ischemic spinal cord injury in rabbits. First, we examined neurotoxicity of 0.3, 1, 2, or 3 mg/kg of magnesium sulfate (n = 6 each). Significant sensory dysfunction was observed in the 3-mg/kg group 7 days after administration. Motor dysfunction was found in two rabbits in both the 2- and 3-mg/kg groups. The area of destruction in laminae V-VII was observed in one, two, and one rabbit in the 1-, 2-, and 3-mg/kg groups, respectively. Second, we investigated the temporal profile (6 h, 48 h, and 96 h [n = 3 each]) of histopathologic changes after 3 mg/kg of magnesium sulfate and confirmed similar changes in the rabbits with motor dysfunction at 48 and 96 h. Third, we evaluated the effects of 0.3 mg/kg or 1 mg/kg of magnesium sulfate or saline (n = 6 each) administered before ischemia on hindlimb motor function and histopathology after spinal cord ischemia (15 min). Magnesium did not improve neurologic or histopathologic outcome 96 h after reperfusion. The results indicate that intrathecal magnesium has a risk of neurotoxicity and shows no evidence of protective effects against ischemic spinal cord injury.
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PMID:Is intrathecal magnesium sulfate safe and protective against ischemic spinal cord injury in rabbits? 1556 76

Motor dysfunction following thoracoabdominal aortic surgery remains as one of their devastating postoperative complications. Recently, many studies have provided information for the mechanisms of ischemic spinal cord injuries and for some strategies against spinal cord ischemia in the perioperative period. Especially, advances in stimulation technique using multipulse could make intraoperative monitoring of functional integrity of motor pathways possible by recording myogenic motor evoked potentials. We summarize the strategies for spinal cord protection, including spinal cord functional monitoring and anesthetic techniques during thoracoabdominal aortic surgery.
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PMID:[Spinal protection and aortic surgery]. 1930 32