Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute type B aortic dissection (ATBAD) with malperfusion is a devastating complication. Especially, the spinal cord ischemia with ATBAD is very rare (3% of total malperfusion cases). Despite the possibility of various arterial involvement in ATBAD, cases of monoplegia due to spinal cord ischemia are extremely rare. Furthermore effective treatments for malperfusion induced spinal cord ischemia have not been established yet. We presented a case of a 62-year-old man with a sudden onset of chest pain and numbness and weakness of the left lower extremity. Follow up CT demonstrated ATBAD starting from below the left subclavian artery to the level of iliac bifurcation without distal reentry, involving malperfusion of the left renal, left intercostal and left lumbar arterial branches. Deciding on endovascular fenestration approach under considering his condition and comorbidity, the right common femoral artery was catheterized and a 5Fr sheath catheter was positioned into the true lumen (Cook Medical, IN, USA). After confirming the catheter was within the compressed true lumen, then aortic fenestration ballooning was performed to enlarge a tearing site by using 12-mm and 20-mm diameter balloons (Boston Scientific, Natick, Mass). The final angiography was demonstrated increased flow in the true lumen of descending aorta with good patency of the left renal artery where no flow had been observed. And enhanced CT confirmed the recovery of flow to the left intercostal and left lumbar branches. Finally the patient achieved the complete recovery of sensory and motor function of his left leg (His preoperative motor grade was 5/0). On postoperative day 3, he walked using a q-cane and now is being followed up on an outpatient basis without no complications. So, we would like to introduce this rare care of left lower monoplegia with ATBAD and suggest endovascular fenestration can be an effective treatment option to treat spinal cord ischemia in ATBAD.
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PMID:Case report: left monoplegia in acute type B aortic dissection. 3279 58

A 57-year-old man presented with sudden neck pain radiating down his arms. This pain progressed to bilateral upper and subsequently lower extremity weakness and numbness. His vitals were notable for systolic blood pressures lower than his baseline (down to 90 mm Hg). The patient's neurological examination as well as magnetic resonance imaging of the cervical and thoracic spine localized to a lesion in the anterior spinal cord. The differential diagnosis for such an acute presentation included stroke, demyelination, intramedullary neoplasm, infection, metabolic myelopathy, and a dural arteriovenous fistula. Further imaging with angiography demonstrated that our patient lacked an anterior spinal artery. In its place, collateral flow from cervical artery branches provided sustenance to the anterior spinal cord. In the setting of hemodynamic instability, this variant anatomy likely predisposed the patient to ischemia, leading to the classic presentation of anterior cord syndrome.
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PMID:Progressive Tetraparesis in a 57-Year-Old Man With Congenital Absence of an Anterior Spinal Artery: A Case of Anterior Spinal Cord Infarction. 3298 52


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