Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022116 (ischemia)
91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the elderly, arterial disease may not necessarily require operative intervention if the patient is not functionally disabled or can adjust to self-imposed limitations. However, with nonhealing skin lesions, gangrene, impending limb loss, or ischemic rest pain, reconstructive arterial surgery must be considered. Pain at rest signals advanced limb-threatening ischemia. The pattern of pain distribution over the foot distinguishes it from common nighttime leg cramps.
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PMID:Peripheral vascular disease: treatment and referral of the elderly. Part I. 388 86