Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 18 section observations of the myorenal syndrome (grave trauma, crash-syndrome, nontraumatic mascular ischemia) in skeletal muscles and the kidneys were investigated. In the skeletal muscles necrobiosis, necrosis with subsequent lysis or calcification of their sarcoplasm, edema of the intermuscular layers with subsequent multiplication of the stroma cells were noted. The kidneys revealed changes typical of a grave acute renal insufficiency. Ischemia of the cortex with atelectasis of glomerular capillaries and their increased permeability were evident. In the proximal tubules there were detected dystrophic changes of the type of granular degeneration and pronounced edema, these changes showing no tendency to reverse development and precluding regeneration of the epithelium. Acute renal insufficiency is closely connected with deep cortical blood flow reduction, the latter acting like a trigger.
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PMID:[Morphologic correlations of changes in the skeletal muscles and kidneys in several variants of the myorenal syndrome]. 125 13