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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A prospective study was made with a view to analyse and to identify two particular forms of the post-thrombotic syndrome. The post-thrombotic syndrome of the shank can be recognized on the basis of the clinical and of the phlebographic examination. It has a serious prognosis and can be treated either conservatively or by surgery according to case. Its frequency is probably higher than it was presumed on the basis of the first observations. The post-thrombotic venous obstruction may be a cause of arterial ischemia during effort but this occurs only in very few cases. This particular syndrome is manifested as intermittent claudication which occurs in the clinical picture of chronic orthostatic venous failure. The probable mechanism is the direct effect of increased pressure in the arterial and venous circulation in vessels with normal walls, as a result of an important obstruction in the return circulation. Lumbal sympathectomy appears to improve durable claudication and hyperhidrosis.
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PMID:[Unique forms of the postthrombotic syndrome]. 252 84

Two patients with both coronary artery disease and leg ischemia were successfully treated with a combined revascularization procedure. Coronary arteries were bypassed with in situ internal mammary artery grafts, and bilateral femoral arteries were bypassed with expanded polytetrafluoroethylene grafts descended from the ascending aorta through the preperitoneal abdominal wall tunnel. Both patients recovered well and experienced no angina or claudication.
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PMID:Combined revascularization of coronary and femoral arteries: a proposed alternative. 257 May 51

To determine the efficacy of extending vascular reconstruction to the pedal vessels, the records of 115 in-situ saphenous vein bypasses to the infragenicular vessels were examined. Ninety-four percent were performed for limb-threatening ischemia and 6 percent for claudication. Ninety-one bypasses were to tibial vessels in the calf (Group 1), whereas severe disease of the tibial vessels in the calf necessitated bypass to arteries at the ankle and beyond in 24 (Group 2). Life-table analysis was used to calculate limb salvage, graft patency, and functional status for Group 1 and Group 2 36 months postoperatively; there were no statistical differences between groups with regard to these variables (p = 0.38). Diabetes had no impact on the success of reconstruction, and preoperative noninvasive testing was not predictive of graft failure in either group. Significantly, limb salvage closely paralleled graft patency and functional status, illustrating the severe disease in all patients. Patients with severe tibial-peroneal atherosclerosis may benefit from bypass grafting to the pedal arteries with a success rate equal to those done to more proximal sites.
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PMID:Results of in-situ saphenous vein bypass to the foot. 258 78

In the presence of peripheral atherosclerotic disease, inappropriate adenosine release during exercise might promote excessive arteriolar dilation leading to steal phenomena and ischemia. In order to test this hypothesis, IV aminophylline (6 mg/kg over fifteen minutes), a dosage known to effectively block adenosine receptors, was acutely administered--in a double-blind, placebo-controlled study design--in 13 patients with intermittent claudication and documented atherosclerotic disease. All patients performed two treadmill exercise tests at the same hour on two consecutive days, five minutes after aminophylline or placebo administration randomly allocated. Pain-free time was 109 +/- 133 (mean +/- SD) seconds after placebo and 173 +/- 165 seconds after aminophylline (p less than .01); maximum time to claudication was 273 +/- 191 seconds after placebo and 397 +/- 318 seconds after aminophylline (p less than .05). The authors conclude that intravenous aminophylline markedly increases the walking capacity in patients with intermittent claudication, possibly by preventing flow maldistribution phenomena through adenosine receptors blockade.
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PMID:Increase of walking capacity after acute aminophylline administration in intermittent claudication. 259 36

Since in stage II of peripheral arterial disease (PAD), according to the definition, there is no objective evidence of danger for the involved extremity, management is dependent on the extent to which the claudication complaints are tolerated (Figure 1). If well tolerated, observation and treatment of risk factors, possibly enrollment in an out-patient training group, are sufficient. Exceptions are the cases of pending danger to viability as well as isolated stenoses in the pelvic region or larger leg arteries easily amendable to percutaneous dilatation. If the patient does not tolerate the complaints, for aortic and pelvic artery occlusions, training of the muscles of the upper thigh is indicated, for occlusions in the thigh training of the calf musculature is warranted. The pathophysiologic basis of training lies in an increase in perfusion via collaterals due to dilatation of the muscular arterioles distal to the stenosis incurred by virtue of work and ischemia. This mechanism may also involve a sheer-induced release of endothelium-derived relaxing factor. Over a moderate period of time, there is an organic increase in collateral caliber due to the perfusion-dependent growth stimulus. A further effect of training is an increase in metabolic activity. If training is unsuccessful, lumen enlarging measures ("LEM" in Figure 1) should be considered. Indications for percutaneous transluminal angioplasty (PTA) are stenoses in the pelvic region or large leg arteries as well as short occlusions of the femoropopliteal vessels (less than 10 cm). With the help of special techniques like rotational angioplasty even occlusions of the pelvic arteries are treatable in selected cases. The five-year patency rate of dilated pelvic artery stenoses is 82%, three-year patency rate for femoral artery stenoses 81% and femoral artery occlusions 78%. Among newer procedures are laser and auger angioplasty, catheter atherectomy and stents. The question of efficacy of platelet inhibiting drugs of the aspirin type, with regard to prophylaxis of early and late re-stenosis remains unsettled. In principle new medical approaches are selective inhibition of thromboxane as well as inhibition of arteriosclerosis-induced proliferation and migration of active mediamyocytes, for example, with highly negative-charged polyanions. For the prophylaxis of peripheral arterial occlusion with aspirin, a dosage of one to 1.5 gram daily would seem appropriate until studies are available to document the effects of lower dosages.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Conservative therapy of arterial occlusive disease]. 264 93

Ischemia of the motoneurons in the anterior horn is a well known pathological entity. Their clinical signs and symptoms are similar to those of amyotrophic lateral sclerosis. Evidence by selective angiography of angiomas of the spinal cord or compression or deviation of Adamkiewicz artery may be suggestive of an initial vascular lesion. Various data (knowledge of development or lesions during experimental ischemia, selective electrophysiologic analysis of anterior horn neurons, evidence of precise circumstances of spinal vascular disorder or spinal arteriography) suggest that anterior horn ischemia is a multiple aspect phenomenon. Our 4 cases illustrate this hypothesis and demonstrate under confirmed vascular circumstances the different clinical aspects of anterior horn ischemic lesions. In addition to typical amyotrophic paralysis unusual or misleading symptoms may occur such as claudication, paroxysmal contractures or progressive spastic paraparesis. Investigations required and possible treatment of the lesions are simplified by awareness of these various clinical aspects.
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PMID:[Ischemia of the anterior horn of the spinal cord]. 264 83

Between January 1, 1969, and December 31, 1984, 55 operative procedures were carried out in 47 patients to correct subclavian-axillary artery lesions resulting from compression at the thoracic outlet. The most common causes of compression were a long cervical rib (27) and an anomalous first rib (15). Presenting features included claudication, vasomotor phenomena, digital gangrene, and acute limb-threatening ischemia. A combined supraclavicular and infraclavicular approach was preferred. Decompression was best achieved by excision of the cervical rib and the first rib and division of all soft tissue elements. The most common methods of arterial repair were resection-anastomosis (23) and replacement of vein graft (11). Embolic occlusions were frequently present (35). Axillary emboli were amenable to direct revascularization at the time of subclavian artery repair. If possible, more-distal embolic occlusions were managed without recourse to embolectomy catheter manipulations. The mean follow-up was 5 years 8 months (range 4 months to 16 years). Patients were assessed clinically, and the arterial repair was monitored by Doppler ultrasonography, B-mode scanning, and digital subtraction angiography. Of the 39 patients available for follow-up, 35 had no symptoms and four had residual claudication. There were no amputations. In the remaining cases the subclavian-axillary artery segment showed no hemodynamic or anatomic abnormality.
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PMID:Arterial complications of the thoracic outlet syndrome: fifty-five operative cases. 265 21

Stiffness of the jaw was noted in the first descriptions of temporal arteritis. It was only in 1944 that Horton used the term intermittent claudication and related this sign to effort ischemia due to thrombosis of facial arteries. The introduction of ultrasound techniques has enabled the permeability of facial arteries to be confirmed in spite of induration and absence of pulsatility clinically. Anatomical studies have defined the preponderant role of the internal maxillary artery in the vascular supply of the masseter muscles and have enabled the localization of an appropriate and reliable site for ultrasound study: the pterygo-maxillary fossa. The velocimetric data thus collected confirm that the internal maxillary artery is affected and define the etiopathogenesis of intermittent jaw claudication during temporal arteritis. This sign is observed on average in one patient in three suffering from temporal arteritis. While several cases of intermittent jaw claudication have been described in severe atheromatous stenosis of the common carotid or external carotid arteries, or in relation to other causes (rheumatological, neoplastic, psychological ...), the observation of this syndrome in a suspicious clinical and paraclinical context constitutes an excellent orientation sign in favor of temporal arteritis.
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PMID:[Intermittent claudication of the jaw in temporal arteritis]. 269 73

Effect of smoking habits on limb loss rates and cumulative patency rates of 136 arterial reconstructions performed for lower limb ischemia were analyzed in a five year follow-up retrospective study. Of 121 patients, 103 (85%) smoked before the operation and 43 of the smokers (42%) discontinued smoking postoperatively. Patients who continued to smoke more than 15 cigarettes per day (34 patients) increased the probability of losing their limb approximately five times at two years and three times at five years postoperatively, compared with nonsmokers and smokers of up to 15 cigarettes per day (87 patients) (p = 0.013). Cumulative patency rates of nonsmokers and smokers of up to five cigarettes per day (Group A, 66 patients) were not significantly influenced (p = 0.518) by preoperative symptoms (claudication versus limb salvage). However, for smokers of more than five cigarettes per day (Group B, 55 patients), at five years claudicants had a cumulative patency rate of 62.9% compared to 38.3% for limb salvage patients (p = 0.015). In group A at five years, autologous saphenous vein grafts had a cumulative patency rate of 74.2%, compared to 24% for prosthetic grafts (P = 0.013). In group B the CPR differences between autologous saphenous vein and prosthetic grafts were not significantly different (p = 0.394). Multiple interactions between smoking and variables like age, preoperative symptoms, and graft material demonstrate the complexity of the effects of smoking on cumulative patency rate and the need for sub-grouping and removal of confounding factors. In view of the adverse affects of continued smoking on postrevascularization prognosis, patients should be strongly advised to discontinue smoking.
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PMID:The effect of postoperative smoking on femoropopliteal bypass grafts. 271 28

The anatomical location of the saphenous vein in the distal thigh allows for construction of an in situ bypass to the above-knee popliteal artery. The authors have performed over 1400 in situ bypasses in the past 10 years. Forty-three of these have been to the above-knee popliteal artery. Thirty-three bypasses were performed for limb threatening ischemia, seven for disabling claudication and three for microemboli. Mean patient age was 67 years, 51% were males, 44% had diabetes mellitus, and 93% smoked. Grafts were followed from one to 108 months. The cumulative patency rate at two years was 90% and at four years 77%. Patency rates compare favorably to those of femoral-to-above-knee popliteal bypasses constructed using reversed saphenous vein or polytetrafluoroethylene. The authors found that the in situ femoral-to-above-knee popliteal bypass is a technically easy procedure requiring short operative times and has a low morbidity rate. In those select patients in whom a femoral-to-above-knee bypass is the procedure of choice the in situ bypass should be considered.
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PMID:The in situ bypass above the knee. 277 34


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