Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Echocardiography was made in 330 patients with ischemic stroke. Group 1 consisted of 72(21.8%) patients with hemodynamic stroke, the rest 258(78.2%) patients (group 2) had other pathogenetic subtypes of stroke. Chronic cardiac pathology was represented by postinfarction cardiosclerosis (38.9 and 17.8% for groups 1 and 2, respectively, p < 0.001) and continuous atrial fibrillation (15.3 and 15.1%, respectively, p > 0.05). Stroke volume of the left ventricle (LV), cardiac output and ejection fraction of the LV were significantly less than in group 2 and in control group but within normal range. The number of group 1 patients having local LV dyskinesia and transitory painless myocardial ischemia was significantly higher than in group 2 (p < 0.001). Painless ischemia correlated with local dyskinesia of the LV (p < 0.02). As transitory myocardial ischemia may deteriorate LV contractility and provoke excessive fall of blood pressure, local LV dyskinesia caused by postinfarction changes seems to be a principal and stable echocardiographic sign of developing hemodynamic stroke.
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PMID:[Echocardiographic alteration in patients with hemodynamic stroke]. 1189 16

We studied pharmacodynamics of an amino acids complex (AAC) in 60 elderly patients (a mean age 71.6 years) with ischemic heart disease, postinfarction cardiosclerosis (PIC), circulatory insufficiency stage I-II. The patients were randomized into 3 groups, 20 persons each. Group 1 received standard therapy (ST) and placebo, group 2--ST + AAC (one tablet of 70 mg 3 times a day), group 3--ST + AAC sublingually in the same dose. Clinical symptoms, results of ECG Holter monitoring and echocardiography were assessed before the treatment and on treatment day 18. Positive effects of AAC used in combination with ST in relation to clinical symptoms, myocardial contractility and ischemia. No differences in efficacy were observed with oral and sublingual AAC administration.
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PMID:[Pharmacodynamics of nonessential amino acids in elderly patients with post-infarction cardiac sclerosis]. 1516 11

We present detailed data on the role of central and peripheral opioid receptors in the regulation of heart resistance to arrhythmogenic factors. Stimulation of peripheral delta2- and kappa1-receptors increases heart resistance to the arrhythmogenic effect of acute ischemia and reperfusion. Activation of peripheral mu- and delta1-opioid receptors improves electrical stability of the heart in animals with postinfarction cardiosclerosis. Possible mechanisms for opioidergic regulation of heart resistance to arrhythmogenic factors are discussed.
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PMID:Opioid receptors and heart resistance to arrhythmogenic factors. 1566 47

The purpose of the study was to investigate the character of clinical and functional manifestations of ischemic cardiac dysfunction in patients with idiopathic coronary microangiopathy, and their correlation with insulin level, as a possible diagnostic criterion of coronary heart disease (CHD). The subjects were 115 men, including 35 individuals (mean age 41.8 +/- 1.2 years) with microvascular form (MVF) of coronary artery lesion, 60 patients with CHD with postinfarction cardiosclerosis (PICS), and 20 healthy individuals. Patients with glucose tolerance disorder, diabetes mellitus, arterial hypertension, and other severe pathology were not included in the study. The diagnostic tests included selective coronaroventriculography with right ventricle endomyocardium biopsy, and myocardial perfusion scintigraphy. Parameters of coronary, intracardial and system hemodynamics were evaluated; insulin and glucose serum levels were measured at rest and during stress-tests with physical exercise. Endocardial biopsy in MVF patients found plastic insufficiency of the endothelium of hemocapillars, prearteriols and cardiomyocytes. Alterations in the parameters of metabolism, intracardial and system hemodynamics, and physical exercise tolerance were found to be comparable in MVF and PICS patients. Insulin level at rest in both groups was equal to that in the control group. At threshold physical load during veloergometry insulin levels in MVF and PICS patients demonstrated comparable elevation (222.8% and 201%, respectively; p < 0.05-0.01). Glucose concentrations in patients with microangiopathy decreased by 28% (p < 0.05), while in patients with CHD it increased significantly by 27.3% (p < 0.05). The study shows that structural and functional lesion of hemocapillar endothelium underlies cardiac syndrome X It results in perfusion ability impairment, chronic hypoxia, impairment of myocardial contractility under the conditions of physical activity. Hyperinsulinemia, manifesting when ischemia is induced, is not caused by insulinresistence. Probably, it presents and adaptive and compensatory reaction to increase of myocardial glucose requirement, and may be one of early CHD markers.
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PMID:[Hyperinsulinemia in patients with microvascular coronary artery lesion as a possible diagnostic criterion of coronary heart disease]. 1607 44

132 patients with complicated forms of chronic calculous cholecystitis combined with heart ischemia and postinfarctial cardiosclerosis were investigated. In preoperative period besides the clinical instrumental and laboratory investigations condition of cardiovascular system with the use of physical exertion -treadmill test and echocardiography was done in order to find the heart's working regime. The analysis of the treadmill tests results with the central and peripheral hemodynamic data changes, the level of myocardial oxygen contribution, metabolic changes has shown that their connection is widely varied. This is explained by inflammatory processes spreading which formed the pathological connection of the whole biliary system and inflammatory focuses with pain sinchrone. Preoperative conservative treatment, including individual mechanisms of heart dysfunction based on treadmill and EchoCG, for the correction of hemodynamic is not necessary on the background of pain, cholemia, pancreas induration which forces myocardium up to the liquidation of pathogenetic mechanism of hepatoduodenal zone. That's why the methods of small invasive endosurgery are used in the complex conservative preoperative treatment.
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PMID:[Corrective strategies in treatment of postoperative hemodynamic dysfunctions in patients with chronic cholelithiasis in combination with the heart ischemic disease]. 1623 85

Data on the antiarrhythmic properties of opioid receptor (OR) agonists have been systematized. An analysis of published works which indicate that opioids increase cardiac tolerance to arrhythmogenic influences both in vivo and in vitro has been performed. For example, occupancy of central micro- and delta-OR and also ORL1 receptors increases cardiac tolerance to arrhythmogenic action epinephrine and aconitine. In contrast, activation of central kapa-OR exacerbates arrhythmogenic action epinephrine. Stimulation of peripheral delta2- and kappa1-OR decreases an incidence of arrhythmias induced coronary artery occlusion and reperfusion in vivo. Occupancy of peripheral micro-, kappa2-, delta1-OR and also ORL1 receptors has no effect on the cardiac tolerance to arrhythmogenic action of ischemia and reperfusion but increases cardiac electrical stability in rats with post-infarction cardiosclerosis. Authors suggest that opioids which unable penetrate to blood barrier may be used for therapy of arrhythmias.
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PMID:[Antiarrhythmic properties of opioid receptor agonists]. 1699 44

A course of treatment (16 mg/kg orally during 5 days) by Aralia mandshurica or Rhodiola rosea extracts reduced the incidence of ischemic and reperfusion ventricular arrhythmias during 10-min ischemia and 10-min reperfusion. Extracts of Eleutherococcus senticosus, Leuzea carthamoides, and Panax ginseng did not change the incidence of ischemic and reperfusion arrhythmias. Chronic treatment by aralia, rhodiola, and eleutherococcus elevated the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. Ginseng and leuzea did not change this parameter in rats with postinfarction cardiosclerosis.
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PMID:Antiarrhythmic activity of phytoadaptogens in short-term ischemia-reperfusion of the heart and postinfarction cardiosclerosis. 1952 55

Contrast-enhanced magnetic resonance tomography (1.5 Tl) was used to examine 101 patients with coronary heart disease. It was shown that angina of effort was associated with disturbed myocardial perfusion manifest during the first passage of the contrast agent at sites with a hypointense signal. Patients with acute myocardial infarction exhibited, besides defective perfusion, hyperintense edematous regions on T2-weighted images as well as hyperintense sites of delayed contrast enhancement. The main symptoms of post-infarction cardiosclerosis in hyperintense zones of delayed contrast enhancement related to cicatrical lesions in myocardium. Disturbances of local contractility depending on the severity of ischemia and cicatrical lesions resulted in the impairment of overall left ventricular contractility.
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PMID:[Magnetic resonance tomography in diagnostics of coronary heart disease]. 2415 93

The paper reports results of endovascular treatment of 66 patients with post-infarction cardiosclerosis. It was shown that normalization of coronary circulation in patients with viable hibernating myocardium in the zone of the affected artery not only eliminates the signs of chronic ischemia and slows down post-infarction heart remodeling but also restores the lost functions of hibernating myocardium which has beneficial influence on prognosis of the disease. Functioning of hibernating myocardium depends on the timely restoration of coronary circulation.
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PMID:[MODERN STRATEGY FOR THE TREATMENT OF PATIENTS WITH "HIBERNATING MYOCARDIUM"]. 2615 6


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