Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pathogenesis of occlusion of the central retinal vessels, based on experimental and clinical findings, is discussed. It suggests that the so-called "central retinal vein occlusion" represents not only occlusion of the central retinal vein but also retinal arterial ischemia. Based on this pathogenesis the following terminology is recommended for central retinal vascular occlusion: (a) Ischemic retinopathy is due to occlusion of the central retinal artery. (b) Venous stasis retinopathy is due to occlusion of the central retinal vein alone. (c) Hemorrhagic retinopathy is due to occlusion of the central retinal vein associated with retinal ischemia. Clinical findings of (b) and (c) are compared which indicate that the two conditions are distinct entities and unfortunately so far have been dumped under a common heading of so-called "central retinal vein occlusions". Such a distinction is extremely important before any attempts are made to evaluate their natural history or effects of any therapy on them.
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PMID:So-called "central retinal vein occlusion". I. Pathogenesis, terminology, clinical features. 125 May 71

Venous stasis retinopathy and ischemic oculopathy are ocular manifestations of ischemia in the distribution of the carotid artery. While not as common as transient monocular blindness or retinal arterial emboli, they are readily recognizable and indicate the presence of severe, often bilateral, carotid occlusive disease. Patterns of occlusion vary but usually include complete occlusion of at least one common or internal carotid artery, often accompanied by occlusion or narrowing in the opposite carotid system. The ocular findings in venous stasis retinopathy and ischemic oculopathy indicate ongoing ocular ischemia and may progress to intractable neovascular glaucoma. Therapy, individualized for the specific pattern of occlusive changes, may be directed toward prevention of stroke or may be indicated primarily for the reversal of ocular ischemia and prevention of blindness secondary to neovascular glaucoma.
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PMID:Chronic ocular ischemia and carotid vascular disease. 402 85