Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the past decade from May 1978 to July 1988, intraaortic balloon pumping (IABP) was used in a total of 108 patients following open-heart surgery at our department. Eleven complications depend on IABP have occurred in nine of theses patients, i.e. five of circulatory disorder on account of ischemia of the lower extremity ipsilateral to balloon catheter insertion, three of ischemia of the abdominal viscera, one of aorto-esophageal fistula, one of gas embolism resulting of balloon rupture and one of damage of the abdominal aorta caused by a Fogarty balloon catheter. Five of these patients died of these complications depend on IABP. Especially, four of five patients died of vascular accidents. These complications were due to operation of the balloon catheter or the driving unit, bat that was no complication related to insert of the balloon catheter. Then, we have to paid more careful attention to driving the intra-aortic balloon.
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PMID:[Complications of IABP in the postoperative management of open-heart surgery--a review of 108 cases in the last 10 years]. 261 16

It is generally accepted that a circulatory disorder of the bowel during the embryonic stage of development plays an important part in the occurrence of atresias of the small bowel and colon, with the exception of the septal types of atresia. In most cases, the cause of this disorder is not known. An experimental study, making use of chick embryos, is presented and the results are discussed. Two sets of experiments were conducted. In the first set the bowel of the chick embryo was subjected to temporary ischemia. In the second one the chick embryo was subjected to a period of general hypoxia. Temporary ischemia of the bowel frequently resulted in stenosis or atresia. The duration of the vascular occlusion was significant factor. Temporary general hypoxia resulted in serious morphologic changes of the bowel and the liver. Stenosis or atresia did not occur in this case, but there was a strong resemblance to the histopathological picture of neonatal necrotizing enterocolitis.
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PMID:The effects of temporary general hypoxia and local ischemia on the development of the intestines: an experimental study. 736 60

Diagnosis and therapy of retinal and uveal circulatory disorders should be based mainly on two pathophysiologic principles: (1) an autoregulation is effective in the retinal circulation only but absent in the choroidal circulation and (2) circulatory disorders may be caused not only be a reduced but also by an increased blood flow. The clinical evaluation of an individual retinal circulatory disorder depends on the interpretation of the dynamics of visual disturbances, detection of vascular type or fiber bundle defects in the visual field, repeated estimation of blood flow velocity by direct ophthalmoscopy or fluorescence angiography, and detection of specific fundus signs such as focal ischemia (cotton wool spots) or development of a collateral circulation and true neovascularization. For the indirect assessment of disturbances of the choroidal circulation certain subjective symptoms, alterations of the pigment epithelium, and edema and focal defects of the choriocapillaries are of importance. The stereobiomicroscopy of the fundus with a slitlamp and fluorescence angiographic studies of the sectorial distribution of the choroidal filling are valuable diagnostic aids.
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PMID:[The hemodynamics of the uveal and retinal circulation and its clinical diagnosis (author's transl)]. 745 19

Circulatory system diseases are the epidemic of our times. According to epidemiologic statistics concerning Poland, they are the major cause of deaths. Among diseases associated with circulatory system, ischemia results in substantial number of deaths. However, we can decrease the risk of ischemia by changing the lifestyle. Our research tries to examine and judge the lifestyle of teenagers from Bytom's schools as well as prevention of circulatory diseases--mainly ischemia is concerned. We examined 205 students from secondary schools. The obtained results are not satisfactory. Lack of knowledge linked with good health manners or even improper and anti-health manners of young people may have significant impact on the development of circulatory system diseases in adult life.
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PMID:[Health behaviors of teenagers from Bytom's high schools and prevention of circulatory diseases]. 1588 1

Nonocclusive mesenteric ischemia (NOMI) is an acute mesenteric circulatory disorder which is characterized by spasm and narrowing of the arterial branches. In contrast to occlusive disease, early diagnosis of NOMI is difficult because of its mild symptoms, thus resulting in a high mortality rate. In this study, we report three cases who survived NOMI because of early diagnosis by multidetector row computed tomography and immediate treatment with prostaglandin E1, which is known to improve blood flow by relaxing vascular smooth muscle. We conclude that early diagnosis and treatment of NOMI with prostaglandin E1 considerably improves the prognosis of this disease.
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PMID:Survival of three nonocclusive mesenteric ischemia patients following early diagnosis by multidetector row computed tomography and prostaglandin E1 treatment. 1901 17

Acute colonic perfusion impairments (thrombosis, infarction, and ischemia) have evident clinical manifestations and are reasonably well described in the literature. At the same time, the problems of chronic peripheral circulatory disorder in the large bowel and the impact of the disorder on its motility are inadequately considered. By summarizing the data available in the literature and their findings, the authors consider the etiology and pathogenesis of organic and functional colostasis in the context of changes in the colonic angioarchitectonics.
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PMID:[Clinicomorphological characteristics of colonic circulatory changes in children with organic and functional colostasis]. 2140 Jul 83

Diseases of the circulatory system are the most common cause of death among women. It should be emphasized that this problem is still underestimated in daily practice. As women are less likely to have significant stenosis in coronary angiography than men, they are regarded to be at smaller risk. At the same time, numerous studies prove that the prognosis of women with ischemic heart disease is serious. Therefore, some researchers suggest distinguishing the so-called "female pattern" of ischemic heart disease, characterized by persistent, often atypical chest pain, positive results for noninvasive tests evaluating ischemia and no significant changes in coronary angiography. It is relevant in the diagnosis of women to assess the global risk, taking into consideration such parameters as inflammation indicators, endothelial dysfunction and microvascular reactivity. There is still no data on optimal treatment, but there seems to be a clear benefit from intensive modification and elimination of risk factors, as well as typical pharmacotherapy with angiotensin-converting enzyme inhibitors, beta-blockers and statins.
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PMID:A female pattern of ischemic heart disease--a new look at an old problem. 2276 18

Peripheral arterial occlusive disease (PAOD) is in about 90% of the cases caused by atherosclerosis. Since this can affect all arteries of the body, PAOD is considered an important indicator of cardiovascular events such as heart attack or stroke, and thus of the leading cause of death in the Western world. With the measurement of the ankle/brachial pressure index (ABI), a practicable method is available to diagnose the disease in routine practice. Besides lifestyle modifications, the mainstay of treatment of atherosclerosis includes also drug treatment of known risk factors. In case of a severe circulatory disorder with critical ischemia, a revascularization by angioplasty or surgical methods is imperative. If the walking distance is limited due to PAOD, we speak of intermittent claudication. Here, in addition to the interventional treatment (percutaneous transluminal angioplasty (PTA) / surgery), a conservative walking exercise can be performed. The supportive use of Padma 28 in the conservative treatment has a measurable effect with a significant extension of the maximum walking distance and poses an additive treatment option.
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PMID:[Padma 28--a useful supplement in the treatment of peripheral arterial occlusive disease in the stages IIa and IIb]. 2386 Jan 9

Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries that reduces functional capacity and quality of life of patients. Despite relatively effective available treatments, PAD is a serious public health issue associated with significant morbidity and mortality. Ischemia-reperfusion (I/R) cycles during PAD are responsible for insufficient oxygen supply, mitochondriopathy, free radical production, and inflammation and lead to events that contribute to myocyte death and remote organ failure. However, the chronology of mitochondrial and cellular events during the ischemic period and at the moment of reperfusion in skeletal muscle fibers has been poorly reviewed. Thus, after a review of the basal myocyte state and normal mitochondrial biology, we discuss the physiopathology of ischemia and reperfusion at the mitochondrial and cellular levels. First we describe the chronology of the deleterious biochemical and mitochondrial mechanisms activated by I/R. Then we discuss skeletal muscle I/R injury in the muscle environment, mitochondrial dynamics, and inflammation. A better understanding of the chronology of the events underlying I/R will allow us to identify key factors in the development of this pathology and point to suitable new therapies. Emerging data on mitochondrial dynamics should help identify new molecular and therapeutic targets and develop protective strategies against PAD.
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PMID:Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion. 2707 18

Peripheral artery disease (PAD) is a common circulatory disorder in which narrowed arteries limit blood flow to the lower extremity and affect millions of people worldwide. Therapeutic angiogenesis has emerged as a promising strategy to treat PAD patients because surgical intervention has been showing limited success. Leg muscles of PAD patients have significantly high level of ROS (reactive oxygen species) and the increased production of ROS is a key mechanism of initiation and progression of PAD. We have recently developed H2O2-responsive polymer PVAX, which is designed to rapidly scavenge H2O2 and release vanillyl alcohol with antioxidant and anti-inflammatory activity. In this study, we investigated the therapeutic efficacy of PVAX nanoparticles for PAD using a cell culture model and a mouse model of hindlimb ischemia. PVAX nanoparticles significantly enhanced the expression of angiogenic inducers such as vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM)-1 in human umbilical vein endothelial cells (HUVEC). PVAX nanoparticles promoted revascularization and restoration of blood perfusion into ischemic tissues by upregulating angiogenic VEGF and PECAM-1. This work demonstrates that H2O2-responsive PVAX nanoparticles facilitate therapeutic angiogenesis and hold tremendous translational potential as therapeutic systems for ischemic diseases such as PAD.
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PMID:H2O2-responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease. 2752 5


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