Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A review of hemorrhagic transformation after brain ischemia is presented. The pathological, clinical and radiological aspects are discussed with respect to recent studies. The different pathophysiological mechanisms (reperfusion, vascular rupture, size of infarction, timing of constitution) are reviewed. The role of the utilization of antithrombotic (anticoagulant and thrombolytic) agents in the production of hemorrhagic infarct is presented, and we propose a new classification of hemorrhagic infarct, based on the CT scan patterns.
 ...
PMID:Hemorrhagic infarcts. 817 97

Page kidney is the name ascribed to a rare syndrome of hyperreninemic hypertension caused by unilateral compressive perinephritis. Blood or fluid that accumulates in the perinephric subcapsular space compresses the renal parenchyma leading to ischemia. This syndrome is analogous to the description of cellophane-induced perinephritis by Page in 1939. Page kidney typically presents in healthy young men after blunt trauma to the flank or abdomen, although cases have been noted after medical or surgical interventions. We report a case of a Page kidney in a young man with hepatitis B virus-associated polyarteritis nodosa. The patient presented with severe hypertension, hypokalemia, hyperreninemia, and radiographic evidence of a unilateral subcapsular hematoma. Perinephric hemorrhage developed because of necrotizing vascular inflammation and spontaneous or traumatic vascular rupture. In patients who present with new-onset hypertension and hypokalemia with a history of trauma or coexisting vasculitis, the presence of a Page kidney should be considered.
 ...
PMID:Hyperreninemic hypertension secondary to a subcapsular perinephric hematoma in a patient with polyarteritis nodosa. 974 Jan 70

Intracranial dissections have only been reported in small case series. More is known about the pathology, clinical findings, treatment and prognosis related to extracranial dissections. Knowing where within the arterial wall the dissection occurs is important in determining the appropriate treatment and prognosis. If the internal aspect of the artery is dissected, between the intima and media, vascular occlusion with resulting ischemia results. When the dissection plane is between the media and adventitia, bulging of the artery, with resultant aneurysmal dilatation, and vascular rupture can occur. In this chapter on intracranial dissections we will first review the pathology and etiology underlying intracranial dissections, then discuss the clinical aspects of both ischemic and aneurysmal intracranial dissections.
 ...
PMID:Intracranial dissections. 1729 Jan 21

Dolichoectasia (dilatative arteriopathy) describes marked elongation, widening, and tortuosity of arteries. The intracranial vertebral and basilar arteries are preferentially involved. Dolichoectatic arteries usually have an abnormally large external diameter and a thin arterial wall, with degeneration of the internal elastic lamina, multiple gaps in the internal elastica, thinning of the media secondary to reticular fiber deficiency, and smooth muscle atrophy. The most important clinical presentations of dilatative arteriopathy include acute brain ischemia; a progressive course related to compression of cranial nerves, the brain stem, or the third ventricle; and catastrophic outcome caused by vascular rupture. Flow in dilated arteries can become bidirectional, resulting in reduced antegrade flow and thrombus formation. Elongation and angulation of arteries can stretch and distort the orifices of arterial branches, leading to decreased blood flow, especially in penetrating branches.
 ...
PMID:Vertebrobasilar dilatative arteriopathy (dolichoectasia). 2014 94