Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study was undertaken to study a role of periods of an individual annual cycle (IAC) (from the date of a birthday to the following one) and the season of a year in patients with coronary heart disease (CHD) in its progression. The study enrolled 52 patients with functional classes II and stable angina pectoris. Clinical and functional parameters were estimated by the data of bicycle ergometric test (BET), 24-hour monitoring (24-h M), ECG, and echocardiography. The vast majority of cases of progression of angina were observed in autumn and winter. Moreover, in patients with angina, the duration of silent ischemia significantly increased and heart rate variability decreased in winter and that of painful ischemia increased in autumn, as evidenced by 24-h M. Trimesters 1 (months 1 to 3 from the date of birth) and particularly IV (months 10 to 12 from the date of birth) have been found to be characterized by a poor course of CHD. Thus, in trimester IV, the duration of total, and silent ischemia significantly prolonged, as shown by 24-h M; episodes of latent coronary insufficiency increased in number, as evidenced by BET. Thus, the course of CHD is determined by a number of biorhythmological factors: the season of a year and the period of IAC.
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PMID:[Biorthythmological risk factors for progression of coronary heart disease]. 1466 69

Reversible left ventricular failure was produced in conscious dogs by compromise of the coronary circulation. In animals with prior left anterior descending coronary artery occlusion, mean left atrial pressure (LAP) was incorporated into an automatic feedback control system used to inflate a balloon cuff on the circumflex (Cfx) coronary artery. The system could produce stable increases in LAP to 15-20 mm Hg. The dominating system transfer function was the ratio of LAP to balloon volume (BV), which was characterized by a fixed delay (5 s), with LAP/BV = (8e(-jomegatau ))/(0.02 + jomega). The system was stabilized by a phase lead network to reduce oscillations of LAP. A total of seven experiments were conducted in three dogs, and testing of inotropic agents was possible in three experiments under stable conditions with the pump off after an hour or more of operation. Problems encountered were 0.003-0.008 Hz oscillations in LAP in three experiments, which could usually be controlled by reducing the system gain. Late stage ventricular fibrillation occurred in all three animals, but defibrillation was easily accomplished after deflating the Cfx balloon. This system produces reversible left ventricular failure solely due to ischemia, thus closely simulating clinical heart failure due to coronary insufficiency.
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PMID:A servo-controlled canine model of stable severe ischemic left ventricular failure. 1981 91

Anomalous origination of a coronary artery from the opposite sinus (ACAOS) is estimated to be present in 0.2-2.0% of the population. In the majority of individuals, ACAOS has no hemodynamic or prognostic implications, but in a minority of cases, typically where the anomalous coronary artery takes an interarterial course to reach its correct myocardial territory, it can precipitate ischemia and sudden cardiac death (SCD). With the growing use of CT coronary angiography (CTCA) in the investigation of ischemic heart disease, we can expect increasing rates of incidental detection of this anomaly. Although CTCA and magnetic resonance coronary angiography can effectively characterize these lesions anatomically, they fail to describe and quantitatively assess the basic defect that leads to coronary insufficiency, such as mural intussusception. The key challenge lies in the identification of which patients are at risk of SCD and, therefore, who should be offered corrective surgical or (potentially) percutaneous intervention. Conventional, noninvasive stress testing has limited sensitivity, but emerging, invasive stress tests, which utilize intravascular ultrasonography and measurements of fractional flow reserve, show the potential to provide more-accurate hemodynamic and prognostic assessment.
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PMID:Anomalous origination of a coronary artery from the opposite sinus. 2198 50

Pain of ischemic and non-ischemic cardiac disease can be referred to the craniofacial region. Also, in 6% of patients, craniofacial pain can be the first and only and symptom of cardiac ischemia. Missed diagnoses of these cases may lead to unnecessary dental treatment and a significant number of deaths in patients with atypical symptoms of coronary disease. Therefore the aim of this report, was to present a 48-year-old man with a chief compliant of severe bilateral pain in the temporomandibular joint who was referred to us for evaluation of a suspected temporomandibular disorder. Clinical and radiological examinations we did not find any origin for his pain. The patient was referred for cardiological evaluation (exercise test, electrocardiography, laboratory tests and coronary angiography) and was diagnosed with angina pectoris. The patient had no previous history of heart disease or chest pain. In conclusion, awareness of this symptomatology can be useful for diagnosis of coronary insufficiency and timely treatment. Therefore, cardiac disease should be considered in the differential diagnosis of orofacial pain.
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PMID:Bilateral temporomandibular joint pain as the first and only symptom of ischemic cardiac disease: a case report. 2249 Apr 49


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