Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a case of life-threatening arrhythmia occurring during tilt table testing in a 44-year-old man with syncope. Polymorphic ventricular tachycardia occurred while the patient was tilted up under the intravenous infusion of isoproterenol (2 micrograms/min). No ischemia, QTc prolongation, or electrolyte abnormality preceded this event. The arrhythmia was not induced by programmed ventricular stimulation or exercise testing. Based on electrophysiological and clinical data, the diagnosis of sick sinus syndrome was entertained.
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PMID:Polymorphic ventricular tachycardia induced during tilt table testing in a patient with syncope and probable dysfunction of the sinus node. 765 63

Polymorphic ventricular tachycardia, which occurs during the subacute phase of myocardial infarction (MI) or ischemia and is not related to ongoing ischemia, has recently been reported. It has characteristics of typical pause-dependent torsades de pointes (TdP) following excessive QT prolongation (post MI/ischemia-associated TdP). We describe a male patient with post MI/ischemia-associated TdP. The patient experienced recurrent TdP with excessive QT prolongation 2 days after transient myocardial ischemia. Genetic screening of the major LQTS-causing genes identified a KCNQ1 G643S variant. This gene variant could be a genetic predisposition to the development of TdP during the subacute phase of MI/ischemia.
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PMID:Post myocardial ischemia-associated torsades de pointes in a patient carrying a KCNQ1 G643S variant. 2113 97

Subarachnoid hemorrhage (SAH) is a neurologic emergency associated with high mortality rate. Polymorphic ventricular tachycardia (VT) is a rare arrhythmia. It can occur in any setting of a long QT interval and bradycardia. This may result from a cardiomyopathy (both ischemic and non-ischemic), acute coronary ischemia, congenital long QT syndrome, electrolyte disturbances and cerebrovascular diseases. We report a rare case of polymorphic VT of unclear etiology with a normal corrected QT, likely secondary to SAH. Reports associating ventricular arrhythmias and SAH have been described, yet the mechanism of this association remains unclear. Previous observations of VT seen in patients with SAH suggest a relationship with QT prolongation. The QT interval, however, remained normal in our patient, suggesting an alternative and unknown mechanism for the polymorphic VT.
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PMID:Polymorphic Ventricular Tachycardia Secondary to Subarachnoid Haemorrhage: A Rare Occurrence in the Setting of Normal QTc. 2911 86