Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Upper limb ischemia presenting in neonatal period is extremely rare. Moreover, presenting newborn with evidence of intrauterine upper limb vascular occlusion is even rarer. It needs prompt intervention to restore perfusion and avoid morbidity. We present a newborn with right upper limb brachial artery thrombosis causing ischemia that was noted at birth and appeared later to be homozygous for factor V Leiden and glycoprotein IIIa with no other identifiable risk factors. In this report, we present the case, its successful medical management, proper counseling, and review of the literature. We recommend investigating the neonates and their parents for thrombophilia mutations when they present with unusual vascular occlusion site as newborns.
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PMID:Intrauterine upper limb ischemia: an unusual presentation of fetal thrombophilia-a case report and review of the literature. 2422 18

Eighteen cases of upper limb ischemia were operated during a 24 month period. Eleven patients presented with features of chronic ischemia, while 7 had acute ischemia with a threatened limb. There were 15 males and 3 females. The average age was 38 years. Associated medical problems were present in 8 patients. Limb perfusion was restored in all patients after direct arterial (bypass) surgery, intra-arterial thrombolysis or percutaneous transluminal angioplasty (PTA). There was no mortality. The limb salvage rate was 100 per cent. Follow-up of upto 24 months reveals a patent bypass in all patients with no recurrence of symptoms. Upper limb ischemia is not uncommon, and can be treated by thrombolysis, angioplasty or bypass surgery. Direct arterial surgery for upper limb revascularization, though technically demanding, is safe and results in relief of symptoms in the vast majority of patients.
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PMID:REVASCULARIZATION OF THE ISCHEMIC UPPER LIMB. 3051 Mar 53