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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present 2 patients with chronic mesenteric ischemia who were successfully treated by mesenteric bypass grafts which then became stenosed and occluded. Patency was restored by percutaneous transluminal dilatation of the stenoses. Chronic mesenteric ischemia affects a population who are at high risk for surgical procedures, and second operations following occlusion of mesenteric grafts appear to carry an increased risk of both morbidity and mortality. We therefore suggest that transluminal angioplasty may prove a valuable form of treatment in these cases.
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PMID:Transluminal angioplasty in the treatment of mesenteric vein graft stenosis. 294 42

Bowel ischemia and infarction are diseases primarily of, but not confined to, the elderly. Insidiously developing bowel ischemia may mimic more common gastrointestinal disturbances, such as peptic ulcer disease or malignancy, and go undiagnosed for long periods. Bowel infarction is a catastrophic event: Mortality rates approach 90%. Chronic intestinal ischemia may precede infarction, or infarction may occur with no warning. Laboratory and radiologic studies have minimal value in diagnosis of these disorders. A high index of suspicion must be maintained in patients complaining of abdominal pain if these diagnoses are to be made promptly.
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PMID:Bowel ischemia and infarction. Chronic and acute causes of abdominal pain. 368 21

Chronic mesenteric ischemia is uncommon in the atherosclerotic age group but is particularly rare in childhood. Because of the nonspecific nature of symptoms produced and absence of pathognomonic findings by physical examination or by routine laboratory testing, its recognition is difficult and its true incidence is unknown. Four children treated for chronic mesenteric ischemia in our center demonstrated the spectrum of clinical presentations and operative considerations important in the management of this uncommon malady. Ages at presentation ranged from 30 months to 17 years. These presentations ranged from clinically silent ischemia in the 30-month-old child to evolving gastrointestinal infarction in the 17-year-old adolescent. Coexistence of abdominal aortic coarctation and/or renal artery stenoses was present in three of the four children. Successful bowel revascularization was achieved by superior mesenteric artery revascularization alone in three children (reimplantation in two and a bypass in one) and by multiple celiac and superior mesenteric artery bypasses in one. Delayed distal small bowel and proximal colonic resection was required in one child. This experience increases awareness that mesenteric ischemia does occur in childhood and is a rare but potentially lethal cause of abdominal complaints in children. Finally, the finding of both renal and visceral artery disease in three of the four patients underscores the need for adequate evaluation of mesenteric vessels before renovascular procedures are undertaken in this age group.
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PMID:Chronic mesenteric ischemia in childhood and adolescence. 405 47

The clinical presentation of mesenteric ischemia depends on the site, grade, and cause of vascular obstruction; the degree of collateralization; and the stage of disease. Patients in the early stages of ischemia typically have abdominal pain out of context with an unimpressive abdominal examination. It is during this stage that medical and endovascular techniques can be most effective. After signs of peritonitis are present (signaling bowel infarction), surgical exploration and bowel resection are necessary. Chronic mesenteric ischemia induced by stenotic arteriosclerosis should be treated with percutaneous transluminal angioplasty and stenting (PTAS). Chronic mesenteric arterial occlusions are better handled with bypass surgery. Acute embolic or thrombotic ischemia is surgically treated after medical resuscitation. Endovascular techniques may be applicable in selected patients (usually in those with subacute symptoms), but thrombolytic therapy should be avoided if intestinal infarction is suspected. Non-occlusive mesenteric ischemia requires a rapid correction of the predisposing hypotension or sepsis followed by papaverine infusion into the superior mesenteric artery. Celiac artery compression syndrome requiring treatment is best treated with surgical release of the median arcuate ligament; PTAS should not be performed. Mesenteric venous occlusion should be treated with anticoagulation. Surgical exploration and bowel resection is necessary in patients presenting with acute signs and symptoms, reserving thrombolytic therapy for early, mildly symptomatic, thromboses in whom there is no contraindication to thrombolysis.
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PMID:Mesenteric Vascular Disease. 1134 65

Chronic mesenteric ischemia is an uncommon manifestation of atherosclerotic disease. The presentation of chronic mesenteric ischemia is often confusing and the diagnosis is usually not made until late in the course of the disease. Selective angiography is considered the gold standard for establishing the diagnosis of chronic mesenteric ischemia. The treatment options for patients presenting with symptomatic chronic mesenteric ischemia include various surgical approaches to revascularization and catheter-based interventions.
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PMID:Chronic mesenteric ischemia: diagnosis and treatment. 1197 99

Mesenteric ischemia is an important clinical condition becoming more prevalent with aging of the population. Mesenteric ischemia may be manifest in an acute presentation, usually secondary to thromboembolism or cardiac insufficiency. Patients have abdominal pain, lactic acidosis, benign abdominal examination, and, often, coexistent multisystem organ dysfunction. Chronic mesenteric ischemia is secondary to proximal arterial stenosis or occlusions inadequately compensated by collateral flow. Clinical presentation may simulate occult malignancy. In this review article, the role of Doppler sonography and other diagnostic imaging tests in suspected acute mesenteric ischemia and mesenteric arterial insufficiency are evaluated with emphasis on diagnostic criteria and appropriate use in each clinical context.
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PMID:Mesenteric ischemia. 1297 81

Chronic mesenteric ischemia is an uncommon condition associated with a high morbidity and mortality. We reported a 36-year old women with postprandial abdominal pain due to chronic mesenteric ischemia caused by a fistula between superior mesenteric and common hepatic artery.
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PMID:Mesenteric ischemia: an unusual presentation of fistula between superior mesenteric artery and common hepatic artery. 1530 Sep 18

Chronic mesenteric ischemia (CMI) is a serious vascular condition that if left untreated may progress to acute ischemia resulting in bowel necrosis and high surgical morbidity/mortality rates. Elective intervention has been shown to prevent this progression and relieve symptoms. Current open surgical intervention involves arterial bypass using a vein or synthetic graft conduit with the inflow originating from the aorta or iliac artery. In some circumstances, the splenic artery provides an additional treatment option for revascularization of the superior mesenteric artery. In certain cases, the splenic artery has several advantages over traditional surgical options. The splenic artery is an arterial conduit much like the internal mammary artery used in coronary artery bypass grafting. These grafts are known for their long-term patency and in selected clinical circumstances are preferred over venous grafts. Because the splenic artery has a natural inflow, only a single vascular anastomosis at the outflow vessel (the SMA) is necessary. This lessens the risk of anastomotic stenosis by decreasing the number of anastomoses created and it makes the procedure shorter in duration. The fact that the inflow is provided by the splenic artery makes cross-clamping of the aorta unnecessary, thereby lessening the risk of producing cardiac ischemia and declamping hypotension. A disadvantage is the risk of splenic ischemia with the possible need for splenectomy. The majority of individuals will have adequate collateral supply to the spleen via the short gastric arteries. The risk to the patient of splenectomy versus the benefits of a less complicated arterial reconstruction with avoidance of aortic cross-clamping must be weighed on a case-by-case basis. Preventing the progression to acute mesenteric ischemia with its increased mortality by timely restoration of adequate vascular supply is an important principle in treating patients with CMI. Controversy still exists over the best treatment option for these patients, whether it be antegrade versus retrograde bypass, single-vessel versus multivessel reconstruction, or open surgical repair versus endovascular intervention. In selected patients, the use of the splenic artery can be considered as an additional option for arterial reconstruction of the SMA.
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PMID:Splenic artery-to-superior mesenteric artery bypass for chronic mesenteric ischemia--a case report. 1549 46

Chronic mesenteric ischemia (CMI) can be treated with surgical revascularization or with angioplasty and stenting. As experience has been gained, endovascular treatment appears safe and effective in selected patients. Currently, surgical revascularization has better success and patency rates but also a higher short- and midterm mortality and morbidity, especially in patients at high surgical risk. A 72-year-old female with severe respiratory dysfunction presented with CMI resulting in profound malnutrition. Serial percutaneous interventions averted urgent surgery and reversed the mesenteric ischemia. Nine months later, after repeated angioplasty and stenting had failed, elective uncomplicated iliomesenteric bypass, in a medically optimized patient, resolved the ischemia. At an 18-month follow-up, the graft remained widely patent and the patient asymptomatic with a body weight corresponding to her ideal body weight. Compared to surgical revascularization, reocclusion or restenosis occurs more frequently after endovascular treatment of CMI, and reintervention may be necessary. Nevertheless, percutaneous intervention effectively provides relief from mesenteric ischemia and has lower perioperative complication rates compared to surgery in patients at high surgical risk. After initial relief of the CMI, the patient's condition may improve, allowing for more definitive secondary surgical revascularization, if needed.
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PMID:Endovascular treatment as a bridge to successful surgical revascularization for chronic mesenteric ischemia. 1558 13

Chronic mesenteric ischemia often called intestinal angina too, is the clinical syndrome that originates as a result of chronic obstruction of the splanchnic arteries. Intestinal angina is defined by the clinical triad of postprandial abdominal pain, sitophobia (fear of eating) and chronic weight loss. Postprandial abdominal pain is analogous to angina pectoris and calf claudication, two more common manifestations of episodic tissue hypoxia. The authors present the case-history of a 50-year-old woman with intestinal angina due to obliteration of the all three main splanchnic arteries. The authors describe the course of the disease and point out new diagnostic approaches in the diagnosis of chronic mesenteric ischemia (Doppler ultrasound of the splanchnic arteries, helical CT angiography of the splanchnic vasculature). In the discussion they point out the possible atypical clinical manifestation of chronic mesenteric ischemia and existence of gastric ulceration and chronic ischemic gastritis caused by chronic mesenteric ischemia.
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PMID:[Chronic mesenteric ischemia]. 1563 5


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