Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ischemic enteritis is a rare disease, but its mortality is high, whether it is caused by anatomic occlusion of the mesenteric macrovasculature or pathophysiologic vasospasm at the microvascular level. Despite advances in the management of the critical ill patient, a large proportion of the patients recognized with this diagnosis succumb acutely to their condition. Lesser degrees of mesenteric ischemia (particularly, in small intestine), even when not manifest overtly as the classic clinical syndrome, may contribute to the development of systemic sepsis and the multiple organ failure syndrome, which leads to death. Therefore, the understanding, recognition, and proper management of mesenteric vascular insufficiency has become very important.
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PMID:[Ischemic enteritis]. 1861 24

Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intestinal lesions as a result of the development of the capsule endoscope and double-balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes.
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PMID:Measurement of small intestinal damage. 2096 49