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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It was the aim of this study to define biochemical parameters of hepatic ischemia. In seven dogs portal vein and hepatic artery were occluded subsequently. During this ischemia the lactate concentration in the hepatic veins rose from a basal value of 15 mg% to 57 mg%. Lactate levels measured in portal vein, femoral artery, and femoral vein were significantly lower. Furthermore, hepatic ischemia caused an increase in potassium and glucose levels in the hepatic vein. Primarily, production of lactate by the liver seems to be an appropriate parameter for hepatic ischemia. Measuring lactate metabolism could be used to examine patients with portal hypertension before performing a shunt procedure. By cannulating the umbilical vein it is possible to occlude the portal vein with a balloon catheter. Portal vein occlusion with hepatic vein blood sampling may identify those patients in whom hepatic arterial reserve is inadequate to support portosystemic shunting.
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PMID:[Biochemical parameters of hepatic ischemia in experimental animals]. 647 4

Portal vein occlusion leads to accumulation of intestinal endotoxin in the portal vein that may be a trigger for release of liver macrophage products from the cells and then for damage to hepaparenchyma. There is activation of Kupffer cells (KC) after ischemia, increasing the volume of second lysosomes, severe erythrophagia was also seen. Moreover, there is an increase in KC count and appearance of young liver macrophages. The rise of KC population counts due to the increased number of functional element play a positive role in clearance of intestinal endotoxin and liver defence for ischemic and recirculatory organ damage.
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PMID:[Changes in the Kupffer cells after reversible ischemia of the liver in rats]. 831 59