Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bilateral parafoveal telangiectasis typically includes the presence of fluorescein staining of outer retinal capillaries, no macular ischemia, right-angled venules, and migration of pigment along these venules. In the bilateral form, atypical parafoveal telangiectasis with macular ischemia but without right-angled venules or migration of pigment along these venules has been reported in only five patients previously. An atypical case is presented of bilateral parafoveal telangiectasis complicated, not only by areas of macular nonperfusion, but also by peripheral ischemia with subsequent anterior and posterior segment neovascularization in the absence of any systemic abnormalities. As in previously reported cases, this patient had no evidence of right-angled venules or pigment migration. Pan-retinal photocoagulation resolved the rubeosis and caused regression of the retinal neovascularization.
Retina 1992
PMID:Atypical parafoveal telangiectasis with subsequent anterior and posterior segment neovascularization. 128 22

An 18-year-old woman with pseudoxanthoma elasticum had sudden profound bilateral visual loss, presumably as a result of optic nerve infarction caused by anemia and hypotension from massive gastrointestinal bleeding. Her central visual acuity largely recovered in her right eye, but her left eye had only hand motions acuity. During the subsequent 24 years, she underwent three separate surgical procedures for gastrointestinal bleeding. Abdominal arterial angiography showed numerous aneurysms of the gastric arteries. A subtotal gastrectomy was done, and histopathologic examination found advanced degenerative changes of the elastic lamina of the gastric arteries. At age 42 years, the patient lost residual vision in her right eye. This was caused by an extrafoveal subretinal choroidal neovascular membrane, which was obliterated with laser photocoagulation. Degeneration of elastic tissue, the primary defect in this syndrome, may cause cardiovascular complications and formation of breaks in the Bruch membrane, which are visible as angioid streaks. Ingrowth of fibrovascular tissue through angioid streaks may cause disturbances of macular function. The optic nerve ischemia and infarction associated with the profound visual loss in this patient reminds the ophthalmologist of the systemic nature of this disorder and the possibility that systemic vascular complications with massive blood loss may occur.
Retina 1992
PMID:Visual loss associated with pseudoxanthoma elasticum. 148 15

Thermal papillitis is a previously unrecognized complication of photocoagulation for peripapillary choroidal neovascularization. This report describes a patient in whom transient thermal papillitis, choroidal ischemia, and two small branch retinal arteriolar occlusions developed after dye red photocoagulation of an idiopathic peripapillary choroidal neovascular membrane.
Retina 1990
PMID:Thermal papillitis after dye red photocoagulation of a peripapillary choroidal neovascular membrane. 170 14

The authors describe in seven eyes of four patients a form of serpiginous choroiditis beginning in the macula without initial peripapillary activity. Eyes with macular serpiginous choroiditis often had a poor visual prognosis and sometimes developed subretinal neovascularization. Fluorescein angiography of the acute lesions showed hypofluorescence; some cases were thus initially diagnosed as having choroidal ischemia. Fluorescein angiography in one eye, however, suggested that at least some of the hypofluorescence seen acutely in eyes with serpiginous choroiditis is secondary to blocked fluorescence from "opaque" retinal pigment epithelium.
Retina 1988
PMID:Macular serpiginous choroiditis. 245 20

Disc neovascularization developed in one eye of a 40-year-old white woman with the acute retinal necrosis syndrome. Krypton laser scatter photocoagulation was placed in areas of nonnecrotic and segmentally nonperfused retina that were demonstrated by fluorescein angiography. Marked reduction in disc neovascularization was noted clinically 16 days after laser treatment and was confirmed angiographically 4 weeks after treatment. Neovascularization was completely regressed at 9 weeks after treatment. The authors postulate that the retinal vasculitis and nonperfusion produced retinal ischemia which stimulated neovascular proliferation, and that photocoagulation caused regression of the neovascularization.
Retina 1988
PMID:Regression of disc neovascularization by photocoagulation in the acute retinal necrosis syndrome. 246 18

The authors report a 70-year-old man who presented with a combined obstruction of both the central retinal artery and the lateral posterior ciliary artery that spontaneously reperfused after 4 days of documented ischemia. Despite this prolonged period of decreased perfusion, visual acuity improved from light perception to 20/30 with the re-establishment of normal retinal and choroidal blood flow as documented with intravenous fluorescein angiography. The theory of retinal tolerance time to obstruction of the central retinal artery and its bearing on possible therapeutic interventions are discussed.
Retina 1988
PMID:Recovery following acute obstruction of the retinal and choroidal circulations. A case history. 323 17

The clinicopathologic features of a 62-year-old woman with the aortic arch syndrome who presented with ischemic ocular inflammation, followed by complete loss of vision, is presented. The pathophysiology and ocular manifestations of chronic ocular ischemia are discussed.
Retina 1986
PMID:Clinicopathologic studies of a case of aortic arch syndrome. 357 91

This article presents the clinicopathologic features of five patients with ocular involvement secondary to carotid artery disease. Three patients had the features of hypotensive retinopathy and two had panocular ischemia. In demonstrating the possible ocular and nonocular sequelae of carotid artery disease, this study stressed the importance of the recognition of the variable ocular features associated with carotid artery occlusive disease.
Retina 1986
PMID:Ocular features of carotid occlusive disease. 357 93

Two cases of large, posteriorly located epiretinal neovascular membranes are presented that were associated with a nasal wedge of retinal ischemia of unknown cause in young Caucasian men without associated systemic disease. A technique of staged, argon laser scatter photocoagulation to the ischemic retina resulted in dramatic regression of the neovascular fronds in both cases.
Retina 1983
PMID:Posterior epiretinal neovascularization associated with sectoral retinal ischemia. 619 5

Unilateral acute retinal necrosis (ARN), developed in a previously healthy 17-year-old boy. Neovascularization of the retina and optic disc was observed when the opaque vitreous was removed by pars plana vitrectomy. Following surgery there was a rapid resolution of neovascularization suggesting that intraocular inflammation, rather than retinal ischemia, was the cause of new vessel formation. Analysis of vitreous mononuclear cells with monoclonal antibodies and the fluorescence-activated cell sorter (FACS) revealed mostly T cells; a pattern consistent with intraocular infection as the cause of ARN. The pathogenesis of intraocular infection is complex and some patients with ARN may be helped by systemic immunosuppression (ie, corticosteroids).
Retina
PMID:Retinal neovascularization associated with acute retinal necrosis. 620 70


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