Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We analyzed 128 electrocardiograms (ECG) of 43 patients with haemorrhagic fever associated with kidney syndrome (HFKS) during an epidemic in 1989, region around Sarajevo. The greatest number of alternations was noticed in toxic phase, and the smallest number in invasive phase of disease. All alternations were transient. Extended QT interval was dominant, and was found in 19 patients (45%). Tall and peaked T wave in the case of 17 patients or in 40%, during toxic and recovering phase, was the second by its frequency. As the third by its frequency, there was U wave manifestation. We found this kind of alternation in the case of 13 patients or in 31%. Incomplete right bundle branch block was the most frequent find during invasive phase of HTKS and it was found in 3/7 of all patients. The same thing was found in 6 patients more, during toxic phase, so in total it was 21%. First degree AV block was presented in 8 patients or 19%. Other finds, ischemia, P-pulmo, arrhythmia etc. had frequency less than 10%.
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PMID:[ECG in patients with hemorrhagic fever]. 136 15

The role of adenosine as a mediator of the bradycardia associated with graded global ischaemia in rat heart was examined. Hearts were perfused at 37 degrees C in the isovolumic mode with Krebs-bicarbonate medium at 12.0 ml/min/g. After equilibration, the coronary flow was reduced to 0.5, 2.5, or 5.0 ml/min/g for 20 min. Effluent was collected and assayed for adenosine and inosine by HPLC. Heart rate was measured and bipolar electrograms were obtained in severely ischaemic hearts. Basal adenosine release was 124 +/- 15 pmol/min/g. Adenosine release increased by approximately 50% in hearts perfused at 5.0 ml/min/g. In hearts perfused at 2.5 and 0.5 ml/min/g, adenosine release increased by approximately 1300 and 2300% respectively. The pattern of adenosine release at 0.5 and 2.5 ml/min/g was phasic, with adenosine release rate increasing to a maximum after about 10 min then dropping to values slightly higher than initial values. Ischaemia produced significant bradycardia and first degree AV block. Adenosine antagonism with 5 micron 8-phenyltheophylline blocked up to 25% of this bradycardia and significantly reduced the conduction delay. Adenosine release rate correlated closely with that component of heart rate slowing which was inhibited by 8-phenyltheophylline. It is concluded that adenosine released during graded global ischaemia mediates up to a quarter of the associated bradycardia. The effect of adenosine is phasic. Adenosine acts primarily to depress the sinus pacemaker. First degree AV block also occurs. These effects were only apparent at coronary flow rates below 5.0 ml/min/g.
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PMID:Mediation by adenosine of bradycardia in rat heart during graded global ischaemia. 321 12