Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tracheal stenosis is a devastating complication of tracheal resection that may be related to improper suture selection and technique, as well as extensive surgical devascularization. This study evaluated Fibrin Sealant (FS) (Immuno AG, Vienna, Austria), a two-component biologic adhesive, as a method for reducing the need for sutures in tracheal surgery. This adhesive has been found to be effective in face-to-face sealing of tissues, wound healing, and in establishing hemostasis. Six adult mongrel dogs underwent tracheal repair with FS. Three had tracheal hemitransections (approximately three quarters of the circumference) and were repaired using one absorbable suture and FS, and three had complete transections (with resection of two tracheal rings each) repaired using five absorbable sutures and FS. The animals were killed at varying intervals ranging from 6 h to 6 weeks. No animal had gross evidence of significant tracheal stenosis, and the endotracheal mucosa appeared well healed. We conclude that the use of FS in tracheal reconstruction results in a stable, leakless trachea, and that it significantly reduces the number of sutures needed; this may lead to a decreased potential for anastomotic ischemia and tracheal stenosis.
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PMID:Use of concentrated fibrinogen in experimental tracheal repair. 371 Nov 35

Tracheal stenosis of the brachiocephalic artery (BCA) is rare, and no definitive treatment protocol has yet been established. Brachiocephalic artery compression of the trachea is also relatively rare. This report presents a case of tracheal stenosis treated by division of the BCA. A 29-year-old woman was admitted because of stridor. Computed tomography (CT) revealed tracheal stenosis caused by compression of the BCA. Brachiocephalic artery suspension or aortopexy was not indicated because she had a thoracic deformity. Therefore, the BCA was divided. The operation was achieved without complications such as ischemia of the right arm or stroke. The stenosis of the trachea was improved. Division of the BCA can be an effective alternative procedure when the tracheal stenosis is caused by the BCA.
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PMID:Tracheal stenosis treated by division of the brachiocephalic artery: Report of a case. 2111 Jan 59