Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Popliteal artery compression may be due to trapping of the artery, a tumor, or a subadventricial cyst. Diagnosis is suggested by the discovery of ischemia in a subject who is often young, this being an unusual finding. It is confirmed by dynamic doppler tests, ultrasonography, and vascular opacification. Eight cases of trapped popliteal, three of osteochondroma, and seven cases due to cysts were observed. Surgical treatment is regularly effective and can prevent complications of embolism and acute thrombosis.
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PMID:[Extrinsic compression of the popliteal artery (author's transl)]. 724 Sep 96

Nonatherosclerotic etiologies of arterial insufficiency are uncommon but important causes of chronic lower extremity ischemia. We report a patient with multiple hereditary exostoses (MHE) presenting with lifestyle-limiting lower extremity claudication and popliteal artery occlusion secondary to a large osteochondroma. The presence of MHE with associated osteochondroma resulting in arterial occlusion is a rare condition. Management strategies for treating large osteochondromas adjacent to or with vessel involvement in asymptomatic patients remain undefined.
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PMID:Multiple hereditary exostoses as a rare nonatherosclerotic etiology of chronic lower extremity ischemia. 2008 8

We report a 38-year-old man who presented successively a thrombosis of the right popliteal vein and the right popliteal artery, responsible of a painful edema of the leg. There was no known thrombophilic predisposing condition. Radiologic assessment, guided by clinical findings, evidenced bilateral femoral and tibial exostosis resulting in a diagnosis of hereditary multiples exostosis. Although anticoagulant treatment with unfractioned heparin was instituted, distal ischemia of the right lower limb developed. Resection of the compressive osteochondroma and an arterial femorotibial bypass venous graft were performed in addition to prolonged anticoagulant therapy. Outcome was eventually favorable. Hereditary multiple exostosis may be asymptomatic for long time. Compression of adjacent vascular structures by an osteochondroma is a rare and potentially serious complication.
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PMID:[Hereditary multiple exostosis revealed by deep vein and arterial popliteal thrombosis]. 2021 72

Osteochondromas or exostoses are the most common benign bone tumors. This is a case of a 16-year-old boy with multiple osteochondromatosis which caused the popliteal pseudoaneurysm and a subsequent distal embolism. Vascular complications, especially acute limb ischemia, caused by osteochondromas are very rare. This abnormality should be searched for when dealing with young patients with acute limb ischemia.
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PMID:Acute Lower Extremity Ischemia due to the Popliteal Pseudoaneurysm in a 16-year-old Boy with Multiple Exostoses. 2382 7

Osteochondroma are the bone tumors most frequently found in adolescents or young adults. Most often discovered by accidental findings, they however may be diagnosed while some complications. They are commonly described as solitary findings while multiple exostoses are rather included in an inherited disease. We report the rare case of a 24-year-old patient with acute ischemia of popliteal artery pseudoaneurysm caused by a femur bone exostosis. He presented a severe and supported pain in the left leg. Clinical examination found acute limb ischemia. An angio-CT-scan showed a pseudoaneurysm thrombosis of popliteal artery with distal emboli. An exostosis of the femur bone just above the aneurysm was also found. In this dramatic presentation, a surgical treatment was performed and consisted of thrombectomy, excluding the popliteal aneurysm with a distal saphenous vein graft, excision of the exostosis, fibrinolysis and preventive anterior and posterior compartements fasciotomy.
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PMID:[Thrombosis of a popliteal pseudoaneurysm secondary to an osteochondroma of the femur: an uncommon clinical case]. 2567 13

Osteochondroma is the most common benign tumor of bones in young patients. It is an unusual cause of nonatherosclerotic peripheral arteriopathy. It is mostly detected in youth and, thus, diagnosis can be delayed since symptoms such as claudication can be confused with muscular cramps. In case of clinical suspicion of peripheral artery disease in the young, the presence of an exostosis should be suspected. We reported our experience of 2 young patients with limb ischemia due to ab extrinseco compression of popliteal artery. In both cases, surgical exeresis of a lower limb exostosis was performed. In the first case, bypass surgery was not required since arterial wall was not damaged. In the second case, an autologous inverted saphenous vein femoro popliteal bypass was performed.
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PMID:Osteochondromas: An Unusual Cause of Vascular Disease in Young Patients: 2 Clinical Cases. 2680 52

Osteochondromas or bone exostoses are bone tumors commonly found in adolescents or young adults. These benign tumors are usually incidentally discovered, exceptionally by a vascular or nervous complication. We report the case of a 22-year-old patient presenting with left femoral exostosis revealed by an acute ischemia of the lower limb. Clinical examination of the contralateral limb was without abnormality. Computed tomography angiography revealed a thrombosed aneurysm of the supra articular popliteal artery associated to an exostosis of the lower extremity of the femur. Surgical treatment was recommended in this patient: resection of the popliteal aneurysm associated with a end-to-end suture of the popliteal artery and resection of bone exostosis.
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PMID:[Acute lower limb ischemia secondary to femoral osteochondroma]. 3102 77

An 11-year-old boy presented with pain in the right knee, intermittent reverse ischemia of the right foot and paraesthesia of the right toes. An angio-CT showed a false aneurysm of the right superior popliteal artery, and a solitary osteochondroma of the posterior aspect of the distal femur. Excision of the aneurysm and the osteochondroma was performed in two-stages. The patient was clinically well at 1-year follow up.
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PMID:False aneurysm of the popliteal artery revealing a solitary osteochondroma of the distal femur in an 11-year-old boy. 3225 93