Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of right sided extradural neurinoma at the level of the foramen magnum is reported which presented as an intramedullary spinal cord syndrome. Ischemia of the anterior spinal artery or of the vertebral artery was considered to be an important pathogenic factor in the production of the neurological syndrome. The outer part of the spinothalamic tract, where sensory fibers carrying pain and thermal sensibility from the sacral segments are situated, escaped ischemia as that part is supplied by penetrating branches of the pial arterial plexus. The discrepancy between the level of neurological deficit (C5) and site of the tumor (C1-2) was due to distant ischemia. The lack of a history of root pain and the rapid recovery following removal of the tumor also favor a vascular origin for the neurological deficit.
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PMID:Intramedullary syndrome due to an extradural neurinoma near the foramen magnum. 7 75

This time trend of hemodynamics and mitochondrial functions were studied to determine whether the ligation of the hepatic artery would result in an antitumor effect on 3'-methyl-4-dimethylaminoazobenzene-induced hepatic carcinoma in rats. The studies revealed that the hepatic tumors were nourished predominantly by the artery and less by the portal vein; the size of the vascular beds in the hepatic tumors decreased as compared with those in the non-tumor area; and as the tumors grew larger, the artery became less predominant and the size of vascular beds decreased further. The mitochondria in the tumor were characterized by impaired growth, impaired oxidative phosphorylation, and by the low activity and nucleotide specificity of membrane bound ATPase. Hepatic dearterialization enhanced ischemia in the tumors and was accompanied by intensified impairment of the aerobic energy production, resulting in necrosis of the tumor. The effects of the dearterialization tended to decrease after the 5th day following the operation. In view of the gross findings upon relaparotomy and the recovery of hemodynamics and mitochondrial functions, this tendency appeared to be chiefly attributed to the increasing collateral circulation.
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PMID:Hepatic dearterialization in 3'-methyl-4-dimethylaminoazo-benzene-induced hepatocellular carcinoma with special reference to circulatory dynamics and mitochondrial functions. 16 34

Systemic causes of leg edema include idiopathic cyclic edema, heart failure, cirrhosis, nephrosis and other hypoproteinemic states. Lymphedema may be primary, or secondary to neoplasm, lymphangitis, retroperitoneal fibrosis and, rarely (in the U.S.), filariasis. Thrombophlebitis and chronic venous insufficiency are not uncommon causes. Finally, infection, ischemia, lipedema, vascular anomalies, tumors and trauma can be responsible for the swollen leg.
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PMID:The swollen leg. 18 30

Nephroblastomas are induced in rats with N-Methyl-N-Nitroso-Urea, and selective renal artery occlusion is performed. This procedure has the same effect like occlusion by embolization. The effect of renal artery occlusion on the growth rate of nephroblastmas is controlled by angiography and gross and microscopic examinations up to 70 days following ischemia, the results are compared with a group of untreated nephroblastoma rats. There is a marked reduction of tumor size and a decrease in tumor proliferation. There is an immediate tumor cell death induced by acute and complete ischemia. Collateral blood vessels cause residual arterial blood supply of tumor parenchyma. There seems to be a correlation between collateral blood delivery and tumor size. Even 70 days after permanent ischemia there are areas of obviously absolute normal tumor cells. The conclusion of this experimental study demonstrated that growth rate of tumors can be reduced by ischemia although potentially malignancy still remains. Clinical embolization therapy is justified only in nonoperable patients with hypernephroma and with massive hematuria.
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PMID:[The influence of renal artery occlusion on tumor growth of experimental nephroblastomas (author's transl)]. 20 93

A method permitting percutaneous catheterization and temporary balloon occlusion of the human renal artery with a 5-F-Swan-Ganz-Catheter is presented. When properly performed, the arterial occlusion is reliable, low in complications, and less traumatizing to the vessel than external clamp occlusion. The technique was employed in 112 patients for occlusion of the renal artery prior to tumor nephrectomy, for attaining stop-flow conditions for improved nephrophlebography, for preventing the reflux of emboli at transarterial embolisation of inoperable kidney tumors, or, combined with simultaneous hypothermic perfusion via the second lumen of the catheter, in extensive kidney surgery necessitating ischemia. Particularly this last range of application offers new possibilities for in-situ surgery of the kidney, as it renders dissection of the renal pedicle and cumbersome surface cooling of the kidney unnecessary.
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PMID:[Intraluminal balloon occlusion of the renal artery: clinical applications and observations (author's transl)]. 32 49

A calyx which fails completely to opacify on excretory urography (phantom calyx) is often the harbinger of serious underlying renal disease. Causes of a phantom calyx include tuberculosis, tumor, calculus, ischemia, trauma, and congenital anomaly. The pathologic basis for the radiographic findings in each of these entities is described and an overall approach to diagnosis is set forth.
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PMID:Nonvisualized ("phantom") renal calyx: causes and radiological approach to diagnosis. 39 18

A double lumen Swan Ganz balloon catheter is introduced percutaneously into the renal artery. Temporary and repeated occlusion of the artery by inflation of the balloon are combined with hypothermic perfusion of the kidney. Thus extensive nephrolithotomies can be done without time limit as in warm ischemia. The operation field is blood-less and the parenchym is protected by perfusion. There is no need for pedicle dissection or external cooling. One complication is seen when the catheter is slipping out of the artery in cases of short renal arteries and the patient is in an extremely bent operation position for intercostal approach. Ballon occlusion without perfusion is helpful in tumor nephrectomy. Preoperative embolization is not necessary when this technique is used. Embolization means an additional procedure with further complications.
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PMID:[Balloon occlusion of the renal artery in operative urology (author's transl)]. 60 Dec 37

During the past few years CT has emerged as an unsurpassed diagnostic modality in cerebrovascular disease. CT is of limited value in TIA, but reveals a wide variety of findings in completed infarcts. Ischemic, petechial, and hemorrhagic infarcts can be distinguished. Contrast enhancement, varying with the age of the infarct, is frequent. Also the general density of the infarct varies with time. Differential diagnosis, primarily infarct vs tumor, is made by angiography or by followup CT scans. Saccular aneurysms are directly demonstrable by CT if larger than 0.5 cm in diameter. Sequelae of ruptured aneurysm--hematoma, hydrocephalus, ischemia--are consistently visible. This generally also applies to arteriovenous malformations. Angiography is necessary to clarify anatomical details of aneurysms and vascular malformations, and is often indispensable for differential diagnosis.
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PMID:CT diagnosis of cerebrovascular disorders--a review. 71 88

To evaluate the biological tolerance of the human liver to prolonged warm ischemia, two groups of extensive hepatic resection for tumor were compared. Group 1 (11 patients) performed with short hepatic inflow occlusion (7 [mean] +/- 2 [SEM] minutes), and group 2 (nine patients) operated with use of complete hepatic vascular exclusion and prolonged warm liver ischemia (38 [mean] +/- 5 [SEM] minutes). Comparison of biological values, such as transaminase, bilirubin, total protein, albumin, and fibrinogen levels, the platelet count, prothrombin complex, and proaccelerin level, did not show statistically significant differences between the two groups. Therefore, the hepatic warm ischemia period may be, if needed, safely extended beyond the classical 15 minutes. It lasted 65 minutes in one case without adverse effect. These clinical observations parallel recent experimental work and should destroy the myth of the high sensitivity of the liver to warm ischemia.
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PMID:Tolerance of the human liver to prolonged normothermic ischemia. A biological study of 20 patients submitted to extensive hepatectomy. 73 77

Transfemoral cannulation of renal vessels with the Seldinger technique has been used as well as routine angiography in the following urologic indications. 1. Hypothermic in situ perfusion of the kidney in difficult surgical procedures on the renal parenchyma, e.g., multiple stones, stag-horn calculi, benign and malignant tumors in solitary, residual or functionally residual kidneys. The advantages of this method are sufficient time for surgery, no contamination of blood and therefore excellent view by means of complete ischemia and good long-term results of the renal function. 2. Embolization of inoperable renal tumors to reduce tumor growth and control bleeding. The material used for embolization was a modified preparation of homogenized autologous muscle tissue. 3. Occlusion of the renal artery prior to tumor nephrectomy by a flow-guided balloon catheter in order to reduce the difficulty of the surgical produce, e.g., in massive carcinomatous infiltration of the hilus vessels. 4. Retrograde phlebography of the left internal spermatic vein in recurrent or persistent varicocele and in infertility with only insignificant or doubtful varicocele. The advantage compared with orthograde phlebography via plexus pampiniformis is the direct evidence that the venous reflux causes the varicocele. When the technique has been mastered transfemoral cannulation of the renal vessels can be used in routinely in the clinic Critical consideration of the indications, however, is necessary.
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PMID:[Transfemoral cannulation of the renal vessels. Diagnostic and therapeutic use in urology (author's transl)]. 84 52


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