Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have studied serially by light and electronmicroscopy the development of lesions of the adipose tissue of the bone marrow of the rabbit following intravenous injections of saponin. Two types of steatonecrotic lesions were seen: in the femur giant-cell granulomas surrounding necrotic fat cells and in the sternum, small foci of fat necrosis containing calcified deposits. In both cases the lesions were of ischemic origin and secondary to the destruction of the microcirculation of the bone marrow by saponin. These studies suggest that necrosis of the bone marrow fat cells can contribute to the pathogenesis of myelofibrosis. They also suggest that adipose tissue responds differently to ischemia depending on topography. In hematopoietic marrow necrosis of fat cells is followed by calcium deposits, whereas in fatty marrow necrosis leads to resorptive giant cell reaction.
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PMID:Experimental bone marrow fat necrosis. 14 11

Twenty men with atherosclerotic lesion of lower extremity arteries verified by contrast angiography and ultrasound Doppler were examined. The patients' age varied from 36 to 69 years (mean 57 years). Six patients had IIB ischemia, 13 presented with degree III and one patient had degree IV ischemia according to the R. Fontaine classification modified by A. V. Pokrovsky. The MOS SF = 36 questionnaire was used to estimate the quality of life of all the patients. The individual typological properties of the personality were defined using the psychodiagnostic test (PDT). A significant decrease of the patients' quality of life was revealed according to the scales: physical function, physical role, physical pain, general health condition. A correlation was recorded between the patient's age and the parameters of the "physical function scale" (r=-0.63; p<0.005). The individual typological properties of the personality exert an effect on five of the eight SF = 36 scales. A feedback was discovered between neurotism and mental health (r=-0.455; P<0.05), conscientiousness and the physical role (r=-0,487; p<0.05); a direct relationship was found between disinhibition and physical pain (r=0.451; p<0.05), general activity and physical pain (r=0.535; p<0.05). An indistinctly pronounced feed back manifested itself between the "neurotism" and "physical pain" scales (r=-0.409), "psychotism" end the "physical role", (r=-0.437), "introversion" and "vitality" (r=-0.408), "femininity" and the "emotional role" (r=-0.404), and a direct relationship was established between the scales "esthetic impressionability" and "vitality" (r=0.406).
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PMID:[Quality of life of patients with atherosclerotic lesion of lower extremity arteries as dependent on individual and typological properties of the patient personality]. 1465 5

The study accrued 28 male patients provided reconstruction for atherosclerotic lesion of lower extremity arteries. Their ages ranged from 36 to 69 years, with a mean of 57.73+/-8.75 years. Degree IIB ischemia according to the R. Fontaine classification modified by A. V. Pokrovsky was present in 10, degree III in 17 patients, and degree IV in one patient. The level end degree of lesion were assessed using contrast angiography and Doppler ultrasound. Before and after operation all the patients underwent measurements of the painless walking distance and regional systolic pressure on the shoulder and ankle as well as of the ankle/brachial pressure index. The quality of life was evaluated in all the patients with the aid of a MOS SF36 questionnaire before and 3 months after operation. The individual and typological personality properties were defined by the psychodiagnostic test (PDT). Operation was followed by a significant rise of the pressure index, painless walking index, and an improvement of the patient's quality of life according to the scales "physical function" and "physical pain". The correlation was established between the painless walking distance and indicators of the "physical function" scale (r=0.48, p<0.05) and "physical pain " (r=0.44, p>0.05) as well as between the ankle/brachial pressure index and general health status (r=0.58, p<0.02). The relationship was revealed between the change in the patient's quality of life after operation and individual-typological personality properties. The correlation coefficient between the scales of "neurotism" according to the PDT: and "physical function", "physical role" and "emotional role" according to the SF36 constituted -0.47, -0.54 and - -0.49 respectively (p<0.05) that between psychotism and the general health status was -0.49 (p<0.05), and that between mental instability and physical and emotional role -0.66 and -0,61 respectively (p<0.01).
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PMID:Assessment of the patient's quality of life in the long-term postoperative period after reconstructions on lower extremity arteries. 1516 82

Since 1990, we have performed splenic autotransplantation in more than 100 patients to treat splenic trauma, portal hypertension, myeloid metaplasia due to myelofibrosis, chronic lymphocytic leukemia, and Gaucher disease. The aim of this present study was to present splenic autotransplantation performed by laparoscopic means. A 33-year-old woman with severe splenic pain due to ischemia caused by multiple focal thromboses of splenic arterial branches was successfully treated by laparoscopic splenectomy and splenic tissue autotransplantation. The spleen was removed and cut in 20 fragments that were sutured to the greater omentum. This procedure was safely conducted with minor bleeding and no technical difficulties or complications. The postoperative follow-up of 12 months has been uneventful; the patient's pain disappeared on the first postoperative day. Hematologic, immunologic, tomographic, and scintigraphic examinations confirmed the functions of the splenic autotransplants. It is feasible and safe to perform splenic autotransplants by laparoscopic means.
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PMID:Laparoscopic splenic autotransplantation. 1692 9

Secondary hyperparathyroidism (HP) presenting with hypocalcemia and subsequent increased parathormone (PTH), is mainly identified in patients with chronic renal failure, which has been associated with variable degrees of bone marrow fibrosis. For suitable patients with end-stage renal disease (ESRD), kidney transplantation is recognized as the therapy of choice, being superior to dialysis in terms of quality of life and long-term mortality risk; in this regard interesting data show that increased time on dialysis prior to kidney transplantation is associated with decreased graft and patient survival. In our opinion an important and until now underestimated determinant of graft survival is the proper activity of bone marrow because of the emerging role of hematopoietic stem cells (HSC) in repair of ischemia/reperfusion (IR) damage. We postulate that in ESRD patients, who usually undergo long dialytic treatment, a myelofibrosis caused by an overt secondary HP could drastically decrease the HSC potential for IR damage repair after kidney transplant; this could irremediably lead to a delay in graft function with all related complicances. If the curative role of bone marrow-derived stem cells was confirmed by more data obtained in experimental animal models, it could be possible to try a cellular-based therapeutic approach in the management of ESRD patients which are in waiting list for a kidney transplant.
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PMID:Is secondary hyperparathyroidism-related myelofibrosis a negative prognostic factor for kidney transplant outcome? 2176 78

A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT.
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PMID:Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis - case report and systematic review of dabigatran use. 3259 18