Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen examples of isolated liver nodules were examined in 7 persons, 4 with single nodules and 3 with multiple nodules. Pathologically they present a spectrum from a solid structure that resembles liver parenchyma with varying degrees of disorganization and fibrosis to soft and fatty enough to superficially resemble a lipoma. Abnormal blood vessels were commonly found in and around the nodules, and the nodules were all ischemic compared to surrounding normal liver. The association of abnormal blood vessels and ischemia may be a cause and effect relationship. Studies by angiography might prove two things: (1) that the presence of abnormal blood vessels is constant in the lesions; (2) that the vessels, although relatively large, fail to provide adequate blood supply to the area, either by lack of branches or by some type of shunting mechanism. Review of cases of "lipoma of the liver" reported in the literature suggest that the lesions described are, in fact, the fatty type of isolated liver nodules.
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PMID:Isolated liver nodules. 115 32

A 71-year old woman initially presented with abdominal pain and an x-ray picture of ischemia of the terminal ileum. The ischemic changes were transient and reversed spontaneously. Six months later, she presented with the same complaint and an x-ray picture of ileocolic intussusception. At operation, a lipoma of the ileum was the leading point of the intussusception and ischemic changes of the ileum were evident.
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PMID:Adult intussusception presenting with transient intestinal ischemia. 740 29

We report the pathologic changes of the cardiac conduction tissue (CS) in 33 cases of sudden cardiac death. The cases were divided into two groups: those with severe atherosclerotic coronary lesion (> 75% cross-sectional area stenosis of at least one coronary artery), 15 cases, and those without significant coronary disease, 18 cases. In the first group, we observed major changes of the CS in eight cases. The changes consisted of abnormalities in His bundle position (branching bundle in pars membranacea or left-sided bundle), atrioventricular (AV) node fibrosis, and interatrial lipoma. Other age-related minor abnormalities such as mild fibrosis, fatty change, or fibrointimal hyperplasia of CS arteries were observed in nine cases. In the second group, major lesions of the CS were recognized in 13 cases: abnormalities in bundle branch position in eight cases (left-sided, inside the membranous septum), downward displacement of the tricuspid valve with AV node elongation in three cases, and a single case with one of the following: His compression by hypertrophic cardiomyopathy, Mahaim fibers, focal ischemia of bundle, AV node division, AV node dissection by edema, intramural left bundle branch, or tumor of the AV node. In the study of the pathogenesis of sudden death, the conduction system lesions always have to be considered, even in cases with severe coronary disease.
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PMID:Pathologic changes of the cardiac conduction tissue in sudden cardiac death. 749 58

The tethered spinal cord syndrome is more often encountered in children, but does also occur in adults. Its clinical spectrum comprises low back pain, neurological deficits such as distal motor weakness and trophic and sensory disturbances in the legs, urological symptoms and such musculoskeletal signs as scoliosis or foot deformities. In addition, cutaneous lesions or subcutaneous lipomas in the lumbosacral region may be indirect signs of an intraspinal pathology. This consists in a tight, thickened and sometimes shortened filum terminale, an intraspinal lipoma, intradural scar formation or other lesions that lead to conus fixation. The common mechanism of injury of these types of pathologies is an impairment of longitudinal movement of the spinal cord, especially the conus medullaris, which subsequently leads to chronic local ischemia. Diagnosis is most readily achieved by magnetic resonance imaging. Treatment is aimed at the restoration of cord mobility by means of microsurgical release of the conus, the cauda equina and the filum terminale with the aid of cauda equina neuromonitoring. Further progression can be effectively halted; in fact almost half of the patient actually improve. Therefore, every patients presenting with the clinical diagnosis of tethered cord syndrome should be offered specialized surgical treatment.
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PMID:[Tethered spinal cord syndrome in adults]. 927 57

Acute appendicitis remains one of the most difficult diagnoses to make in the Emergency Department. We present a puzzling and unusual case. A 47-year-old man had several hours of acute abdominal pain in the right upper quadrant, point tenderness in the right midquadrant on examination, and normal chemistries. Early appendicitis was suspected and a computed tomography (CT) scan of the abdomen was obtained. Appendicitis was not seen. What was evident was a retroperitoneal lipoma estimated to weigh 10 pounds. The general surgeon was consulted who believed that operation was necessary in light of the patient's continuing abdominal pain and the presence of the mass. Masses this large could cause pain from local compression of structures, or ischemia of the mass from outgrowing its blood supply. In surgery, a lipoma was observed that filled most of the retroperitoneum and displaced all the contents of the abdomen, including the cecum and its appendix. Also present was an acute appendicitis. On retrospective analysis of the CT scan, the appendicitis was evident but atypically located in the epigastrium. This case illustrates once again that the CT scan is a useful diagnostic adjunct for the diagnosis of new onset abdominal pain and specifically for appendicitis.
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PMID:Appendicitis masquerading as tumor: a case of two diagnoses. 1172 67

Cardiac papillary fibroelastoma (CPF) is a rare primary benign cardiac tumor. Before the use of echocardiography, the lesion was identified at autopsy or incidentally during cardiac surgery. CPF is the third most common primary cardiac tumor after atrial myxoma and lipoma, and is the most common tumor of the valvular endothelium. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) permit diagnosis of the tumor in living patients. CPF may be the cause of cerebrovascular or cardiac ischemia due to embolization or occlusion of the vascular ostia. Embolic material may arise from fragments of the tumor itself, or from surrounding thrombus. The case is reported of a patient with CPF of the aortic valve in whom TEE diagnosis was conducted and the tumor removed surgically.
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PMID:Aortic valve papillary fibroelastoma. 1570 Apr 49

Jejunojejunal intussusception and jejunojejunal lipomas are both very rare clinical entities. The present case report describes this event in an adult patient with severe episodes of hematochezia and colicky upper abdominal pain. The diagnosis was not made preoperatively, as none of the endoscopic findings were pathognomonic and, furthermore, CT scans could not rule out malignancy. Exploratory laparotomy was mandatory and at surgery a jejunojejunal intussusception secondary to a lipoma was found. Segmental resection and primary reanastomosis were performed in the presence of evidence of bowel ischemia.
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PMID:Jejunojejunal lipoma causing intussusception. 2318 50

Primary cardiac tumors are uncommon, and papillary fibroelastoma is considered relatively rare compared to myxoma and lipoma in the primary cardiac tumors. We experienced three cases of fibroelastoma. The patients' age was 28-75 years, and one patient was female. Two patients were presented with cerebral infarction and cardiac ischemia although, the other patient had no symptoms. Echocardiography revealed a hyperechoic mass in the left atrium, ventricle and on the aortic valve and helpful for differential diagnosis from myxoma. Surgical excision of the tumor was successfully performed in all patients and post-operative course was uncomplicated.
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PMID:Cardiac papillary fibroelastoma: report of three cases. 2408 11

Cardiac lipomas are rare and usually present as benign, encapsulated masses outside the heart; however, they can also be found within the atria. No single theory-including molecular genetic mutation-adequately explains why this occurs. Extensive career experience and broadened knowledge in embryology and cardiac physiology have helped us to develop a hypothesis based on invagination of extracardiac tumors. This report describes a vexing case of a giant right atrial lipoma, from 1985, in which the diagnosis was made incidentally during management of a patient's acute limb ischemia. In addition, we discuss the imaging and treatment of cardiac lipoma.
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PMID:Giant Cardiac Lipoma: Refined Hypothesis Proposes Invagination from Extracardiac to Intracardiac Sites. 2777 37

Lipomas of the gastrointestinal tract are uncommon benign tumors of mature adipocytes and may occur in any portion along the gut. Depending on location they may have a variety of clinical presentations and even simulate malignant neoplasms. We report a case of a 58-year-old woman who presented with acute pelvic pain. An emergency sonogram detected a hyperechogenic mass in the left adnexal region, with no vascularization on Doppler. A computed tomography confirmed the hypothesis of a fat containing tumor with signals of torsion. The patient underwent laparoscopy which depicted a mass over the antimesenteric side of the sigmoid with signs of ischemia and twisted vascular pedicle. The lesion was resected, and the microscopy confirmed the diagnosis of lipoma. The multidisciplinary team in the emergency room must be aware of these possible complications in order to optimize patient care.
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PMID:Torsion of a giant antimesenteric lipoma of the sigmoid: a rare cause of acute abdomen. 3009 28


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