Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A rare presentation of arterial thoracic outlet syndrome (TOS) is described in a young woman. Arterial TOS caused by a cervical rib produced acute upper extremity ischemia due to subclavian artery aneurysm formation. Clinical presentation also included left hemiparesis caused by right subclavian artery thrombosis and retrograde embolization of thrombus via the common carotid artery to the right middle cerebral artery distribution. Surgical repair of the subclavian artery was performed, but permanent neurologic deficit remained. Acute thrombosis of the right subclavian artery can produce cerebrovascular complication. The assessment of such risk in patients with arterial TOS is warranted and the arterial lesion corrected surgically.
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PMID:Cerebral embolic stroke and arm ischemia in a teenager with arterial thoracic outlet syndrome: a case report. 1759 94

We encountered an instructive case of repetitive reversible severe neurological deficit due to ischemia of the internal capsule after mild head injury. A 1-year-old boy fell and hit his head on the floor without losing consciousness. Intermittent episodes of left hemiparesis lasting from 30 s to 30 min developed 4 h later. Magnetic resonance (MR) imaging revealed acute infarction in the left internal capsule and corona radiata on diffusion-weighted imaging, and no microbleeding on susceptibility-weighted imaging. MR angiography of the intracranial and cervical vessels showed no obstruction of the large cerebral arteries. Motor impairment began to improve the next day with conservative therapy. Neurological deficit gradually resolved over the course of 1 month. This tiny lesion of the internal capsule and corona radiata may have represented a small infarction caused by mechanical vasospasm of the perforating vessels branching from the middle cerebral artery after minor injury. Even mild head injuries may cause infarction of the internal capsule, although minor head injuries are common accidents in childhood and usually do not result in severe complications.
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PMID:Ischemia of the internal capsule due to mild head injury in a child. 1762 49

Intracranial dural arteriovenous fistulas (AVFs) are potentially at risk for hemorrhage, and their symptoms and prognosis are highly variable. We present 7 surgical cases with the initial symptoms of venous ischemia by dural AVF. The series comprises 3 male and 4 female, ranging in age from 37 to 76 years (mean age, 61.1 years). Initial symptoms were dizziness in 3 cases, headache in 2 cases, unconsciousness in 1 case, and hemiparesis in 1 case. The locations included the superior sagittal sinus in 3 cases and the transverse-sigmoid sinus in 4 cases. Computed tomography with contrast media and magnetic resonance imaging revealed abnormal vessels. In all cases, retrograde feeding into the cortical veins was observed. On angiography, multiple retrograde venous drainage into the cortical veins were observed in all cases. Single photon emission computed tomography (SPECT) demonstrated apparent hypoperfusion in all 7 cases and further decrease by diamox challenging test in 4 cases. The dural AVFs were removed, and the symptoms disappeared in all cases, although transient aphasia was observed in a single case postoperatively. Postoperative SPECT showed improvement of cerebral blood flow in 4 and no change in 2 of 6 follow-up cases. Cerebral ischemia was induced by venous hypertension, and the hypoperfused brain improved immediately after the operation. Cerebral venous ischemia is a reversible condition that can be improved by appropriate early-stage treatment.
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PMID:Cerebral venous ischemia by dural arteriovenous fistulas. 1790 17

Approximately 20% of coronary artery anomalies produce sudden death or life-threatening symptoms, including arrhythmias, syncope, and myocardial infarction. The most common clinical symptom of coronary artery anomaly is angina or exertional syncope. Physical examination is usually unrevealing in the absence of myocardial infarction or symptoms of ongoing ischemia. The rapid advent of cardiac computed tomography (CT) technology has made it an important adjunct to the diagnosis of coronary anomalies by angiography. The authors describe the case of a 54-year-old white man who presented with gangrenous toes. He had severe peripheral vascular disease, a femoral-popliteal bypass graft, residual hemiparesis from an ischemic stroke, hypertension, deep vein thrombosis, and a recent myocardial infarction. He underwent a 64-slice cardiac CT angiogram, which showed an interarterial course of the left main coronary artery between the aorta and the pulmonary trunk.
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PMID:Evaluation of anomalous aortic origins of the coronaries by 64-slice cardiac computed tomography. 1793 19

We report about a 42-year-old patient who was admitted to the emergency department because of suspected alcohol abuse. He declared himself to be drunk. He stated in his case history that he had suffered from right sided neck and facial pain for several days. The clinical examination revealed a left sided hemiparesis. Together with the demonstrated right hemispherical brain ischemia by computed tomography, a presumptive diagnosis of a dissection of the right internal carotid artery was made. This diagnosis was finally confirmed by ultrasound and magnetic resonance imaging. A therapy with full dose heparin was begun and oral anticoagulation was subsequently initiated. After two weeks of follow-up, the neurological deficiencies were partially regredient.
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PMID:[Really drunk?]. 1805 Jun 2

Three cases of internal carotid artery (ICA) dissection due to trivial trauma were reported. A 14-year-old, previously healthy, girl developed left hemiparesis after jogging. MRI sh owed cerebral infarction in the right basal ganglia and the MR angiography (MRA) revealed luminal narrowing of the right ICA as well as pseudolumen at the origin of the right ICA. She was treated with antithrombotic therapy. Follow-up MRA demonstrated normal signal in the right ICA. A 23-year-old woman admitted to the hospital because of minor facial injury due to a traffic accident. Although she had no apparent symptom, follow-up CT, one day after presentation,. showed cerebral infarction in the right basal ganglia. Angiography showed diminished luminal diameter of the right ICA. She was treated with antithrombotic therapy and follow-up angiography showed reconstitution of normal lumina of the right ICA. A 34-year-old woman was referred to our hospital because of transient ischemic attack following swimming. Neurological examination was normal and MRI did not show any ischemic lesion. MRA revealed diminished signal in the left ICA as well as string and pearl sign at the origin of the left ICA. She was treated with antithrombotic therapy, and follow-up angiography showed normalization of the left ICA. Cervical ICA dissection due to trivial trauma usually appears as an eccentric tapered stenosis arising at the origin of the ICA and resolves with complete or excellent recovery in most cases. Surgical or endovascular treatment should be reserved for patients who have persistent symptoms of ischemia despite adequate antithrombotic treatment.
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PMID:[Three cases of internal carotid artery dissection due to trivial trauma]. 1808 May 18

Hypoglycemic hemiparesis is rare and can be misdiagnosed as cerebral infarction or transient ischemic attack. Early diagnosis of these two disorders is critical because, if not treated with prompt glucose administration, hypoglycemia may lead to a fatal clinical course. We reported two cases of hypoglycemic hemiparesis with a reversible splenial lesion on MRI. The first case was a 69-year-old woman presenting with dysarthria and right hemiparesis. The second case was a 60-year-old man presenting with right hemiparesis. Plasma glucose level was 39 mg/d/ and 32 mg/d/, respectively. In both cases, initial diffusion-weighted imaging (DWI) showed hyperintensity lesions with decreased apparent diffusion coefficient (ADC) values in the splenium of the corpus callosum. Following appropriate correction of hypoglycemia, repeat DWI showed complete resolution of hyperintensity lesions with normalized ADC values. These findings can provide complementary information in the differential diagnosis of hypoglycemic hemiparesis and stroke, though underlying pathophysiological mechanisms are still elusive. We emphasize that checking plasma glucose level is necessary even in cases with hemiparesis. Furthermore, we should be aware that not every hyperintensity lesion on DWI is due to ischemia. There are times when it could be due to hypoglycemia.
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PMID:[Reversible splenial lesion of the corpus callosum on diffusion-weighted magnetic resonance imaging in hypoglycemic hemiparesis: report of two cases]. 1943 96

A 68-year-old man presented with sudden onset of left hemiparesis, diplopia and numbness of the left side of the body and was admitted to our hospital. MRI of the brain revealed no abnormality. However, neurological examination on admission strongly suggested ischemia of the brainstem. Under anticoagulation therapy his symptoms gradually disappeared by the fourth hospital day. He had a past history of bouts of unconsciousness caused by right rotation of the head. Dynamic plain roentgenograms of the cervical spine showed spondylotic changes and lateral osteophyte formation at C5/6 without instability. Computed tomography (CT)-angiography demonstrated narrowing of the right vertebral artery due to compression of the lateral osteophyte at C5/6. Vertebral angiography revealed complete occlusion of the right vertebral artery induced by right rotation of the head. The artery-to-artery embolism caused by repeated occlusion of the right vertebral artery due to the neck motion was suggested as the mechanism of ischemic attack in this patient. Osteophytectomy at C5/6 via the anterior approach successfully treated dynamic occlusion of the right vertebral artery. Occlusion of the vertebral artery at C1/2 by the head rotation is well known as Bow-Hunter's syndrome. However, dynamic occlusion due to spondylotic changes at C5/6 is rare. In case of ischemic attack of the posterior circulation with lateral osteophyte formation of the cervical spine, dynamic occlusion mechanisms of the vertebral artery at the lower cervical level should be considered.
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PMID:[Cerebral ischemia originating from rotational vertebral artery occlusion caused by C5/6 spondylotic changes: a case report]. 1966 39

Crescendo transient ischemic attacks (TIAs) are defined as repeated frequent short-lasting episodes of focal neurologic deficit due to cerebral ischemia. The capsular warning syndrome, a subset of crescendo TIA, consists of repetitive episodes of motor dysfunction due to ischemia in the region of internal capsule. It is not clear that patients with ischemia in the pons can have a similar clinical presentation and course. We report 11 cases presenting with crescendo TIA in the form of pure motor hemiparesis or ataxic hemiparesis that later proved to have a paramedian pontine infarct. The presumed mechanism of these infarcts is penetrating basilar artery branch occlusion at their origin, also called basilar branch disease.
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PMID:Pontine warning syndrome: case series and review of literature. 2044 24

A 64-year-old female with a history of primary biliary cirrhosis and esophageal varices starting at age 39 was brought to our Stroke Care Unit by ambulance with right-side weakness and speech difficulty. Physical examination revealed right hemiparesis (including the face), sensory disturbances, pathological reflexes, and slightly decreased consciousness, with a Glasgow Coma Scale rating of E3V4M6. Flapping tremors and speech disturbance, as well as anarithmia, construction apraxia, and ideomotor apraxia, were noted, and her National Institutes of Health Stroke Scale score was 13. Initially, the patient was diagnosed with acute stroke and treated accordingly; however, subsequent findings from clinical images and electroencephalography led to a diagnosis of focal neurologic signs due to hepatic encephalopathy (HE). The patient had significantly reduced cerebral blood flow in the left side of the brain, probably due to microsurgical repair of an aneurysm done 2 years earlier. HE with exaggerated chronic liver damage might have made the previously silent ischemia clinically apparent. This interpretation is supported by the fact that the patient's neurologic deficits resolved once HE was adequately controlled. This case illustrates the need for careful assessment of background pathophysiology when diagnosing patients with stroke-like symptoms.
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PMID:Hepatic encephalopathy with reversible focal neurologic signs resembling acute stroke: case report. 2063 97


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