Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IBD 12.0
PDZD3 12.0
DDXL 12.0
ZNF713 11.0
5-HT3E 10.4
klotho beta 10.4
Neurokinin-2 receptor 10.4
CUZD1 10.4
HTR3E 10.1
Lipase H 10.0
nuclear receptor binding factor 2 10.0
BTN2A2 10.0
FAM118A 10.0
CTXL 10.0
HTR3D 9.7
SSPO 9.6
TACR2 9.6
ZUD 9.6
PDZ domain-containing protein 2 9.6
Noxp20 9.6
SYT8 9.4
HTR3C 9.2
HTR3 9.1
BTNL9 9.1
TTC7A 9.0
KV7.4 9.0
TJP3 9.0
tetratricopeptide repeat domain 7A 9.0
ANKZF1 8.8
BTNL8 8.8
IBD1 8.7
TSPAN15 8.6
BTNL3 8.5
protein tyrosine phosphatase receptor type C 8.5
CLC2 8.5
CADM1 protein 8.5
IBD2 8.5
ENTPD5 8.4
SUGT1 8.4
TOB2 8.4
RNF186 8.4
CC28 8.4
OATP6A1 8.4
INADL 8.4
HTR3A 8.3
CORO1C 8.3
NRBF2 8.3
GLVR1 8.3
ARIH2 8.3
PKIB 8.1
B2GPI 8.1
LY9 8.1
5-HT4 8.0
uroguanylin 8.0
ISLR 8.0
PTP36 8.0
GUCY2C 7.9
mast cell protease II 7.9
transmembrane protein 16A 7.9
aconitase 2 7.9
TPSAB1 7.9
HTR3B 7.8
PTPsigma 7.8
FSHD1A 7.8
5-HT4 receptor 7.7
M-BAR 7.7
UBXD8 7.7
PTPRS 7.6
TESK1 7.6
cellugyrin 7.6
muscarinic acetylcholine receptor M3 7.6
isobutyryl-CoA dehydrogenase 7.6
P2RY5 7.6
EEN 7.5
Macrosialin 7.5
PPP2R5C 7.5
SSX2IP 7.5
IL18RAP 7.5
TTC37 7.5
BTN3A3 7.4
more...
Disease
Chlamydial prostatitis 12.0
Parastomal ulceration 12.0
FIGD 12.0
Irritable bowel syndrome with diarrhea 12.0
Diarrhea predominant irritable bowel syndrome 12.0
Hypogammaglobulinemic sprue 12.0
Colonic dysfunction 12.0
Constipation predominant irritable bowel syndrome 12.0
irritable bowel syndrome 12.0
spastic colon syndrome 11.2
functional diarrhea 11.2
splenic flexure syndrome 11.0
enteroptosis 11.0
Chronic idiopathic constipation 10.5
Gastric motor dysfunction 10.4
Infrequent bowel movements 10.4
Painful Bladder Syndrome 10.4
Osmotic diarrhea 10.1
Pericholangitis 10.0
Food sensitivity 10.0
TB salpingitis 10.0
Bacterial gastroenteritis 9.8
Cathartic colon 9.6
Pelvic floor dyssynergia 9.6
Functional Gastrointestinal Disorders 9.6
Rhinotracheitis 9.6
abdominal migraine 9.6
IDDM11 9.4
IBD6 9.4
Situational anxiety 9.4
infectious gastroenteritis 9.1
gluten sensitivity 9.1
Functional dyspepsia 9.1
IBD3 9.0
IBD2 9.0
Campylobacter jejuni gastroenteritis 9.0
aerophagia 8.9
IBD5 8.9
gastrointestinal disease 8.8
organic disease 8.8
Blastocystis infection 8.8
Secretory diarrhea 8.8
visceroptosis 8.6
Inflammatory Bowel Disease 8.6
inflammatory bowel disease 8.6
dyspepsia 8.5
cardiophobia 8.5
Digestive Diseases 8.5
Bowel dysfunction 8.5
lactose intolerance 8.4
dolichocolon 8.4
proctalgia fugax 8.4
EBS2 8.4
Upper gastrointestinal symptoms 8.3
infectious enteritis 8.2
Traveler's diarrhea 8.2
Adenomatosis 8.1
disaccharidase deficiency 8.1
Witts 8.1
Secondary sclerosing cholangitis 8.0
Nutcracker esophagus 8.0
fructosuria 8.0
Microscopic colitis 7.9
interstitial cystitis 7.9
Gastrointestinal lymphoma 7.9
Clostridium difficile colitis 7.8
gastrointestinal infection 7.8
ischemic colitis 7.8
fibromyalgia 7.8
AGEP 7.8
FBD 7.8
infectious colitis 7.8
tropical sprue 7.7
Infectious bursal disease 7.7
diverticular disease 7.5
laxative abuse 7.5
Chronic colitis 7.5
Ovarian remnant syndrome 7.5
Colonic volvulus 7.5
neuromyasthenia 7.4
more...
Symptom
Other chronic pain 12.0
Simple constipation 12.0
Epigastric discomfort 11.0
change in bowel movements 10.7
Functional abdominal pain 10.3
change in stool 10.2
GI pain 10.0
intestinal pain 10.0
Chronic abdominal pain 9.8
bloating 9.8
Visceral pain 9.7
Psychological symptom 9.1
gastrointestinal gas 9.0
chronic constipation 8.8
Food intolerance 8.7
constipation 8.6
Chronic pelvic pain 8.4
Functional constipation 8.4
rectal pain 8.3
Gastrointestinal symptoms 8.0
Watery diarrhea 7.9
belching 7.8
Pain symptoms 7.7
abdominal discomfort 7.7
Mucosal hyperplasia 7.7
generalized pain 7.7
Upper abdominal pain 7.6
dysorexia 7.6
bladder pain 7.5
vestibulitis 7.5
Lower abdominal pain 7.4
Cramping 7.3
Wind 7.2
McBurney's point 7.1
Chronic pelvic pain syndrome 7.1
abdominal pain 7.1
diarrhea 6.6
acid regurgitation 6.6
dyschezia 6.5
heartburn 6.5
epigastric distress 6.4
generalized abdominal pain 6.4
Central pain 6.3
pelvic pain 6.2
Severe diarrhea 6.1
Infantile colic 6.1
abdominal cramps 6.1
left lower quadrant pain 6.0
Joint hypermobility 6.0
hyperemesis 5.7
situational stress 5.6
stomach pain 5.6
discomfort 5.5
Vulvodynia 5.5
Spastic 5.5
discomfort 5.4
epigastric pain 5.3
colic 5.3
Musculoskeletal symptoms 5.2
coccygodynia 5.2
alexithymia 5.2
Multimorbidity 5.1
tenesmus 5.1
lassitude 4.8
leg cramps 4.8
iliac fossa pain 4.7
urinary frequency 4.6
loin pain 4.6
Flare 4.5
nausea 4.4
Poor sleep 4.4
pachyonychia 4.4
hyperemesis gravidarum 4.4
chronic back pain 4.4
halitosis 4.3
giddiness 4.3
renal colic 4.3
giddiness 4.3
nausea and vomiting 4.3
hand pain 4.3
more...
Drug
Alosetron 11.8
Alosetron hydrochloride 11.4
Tegaserod 11.3
Cilansetron 11.2
Tegaserod 11.2
Bentyl 11.0
Clidinium bromide 11.0
Amitiza 10.7
Calcium polycarbophil 10.5
Trimebutine maleate 10.1
Merbentyl 10.0
Prifinium bromide 10.0
Ezlopitant 9.8
Caraway oil 9.6
Renzapride 9.5
Peppermint oil 9.4
Rifaximin 9.3
Visilizumab 9.1
Almond oil 9.0
Crofelemer 8.7
Mosapride citrate 8.6
Polycarbophil 8.4
Nafarelin acetate 8.1
Nafarelin acetate 8.1
Peppermint 7.7
Dipentum 7.6
Darifenacin 7.4
Kytril 7.4
Kytril 7.3
Colesevelam 7.2
Prostigmin 7.0
Imodium 7.0
Loxiglumide 7.0
Belladonna 6.9
Palonosetron hydrochloride 6.9
Questran 6.8
Alvimopan 6.8
Lomotil 6.7
Mesalazine 6.7
Lomotil 6.7
Imodium 6.7
Plaquenil 6.6
Cisapride 6.5
Plaquenil 6.5
Rapamune 6.5
Dextropropoxyphene 6.0
Dextran sulfate sodium 5.9
Infliximab 5.9
Infliximab 5.9
Lactase 5.8
Fosamax 5.8
Sulphasalazine 5.7
Catapres 5.7
Buscopan 5.7
Menthol 5.7
Giardiasis 5.7
CFS 5.4
Bosutinib 5.4
Bifidobacterium 5.4
Budesonide 5.2
Lactose 5.1
Pregabalin 4.8
Nitazoxanide 4.7
Domperidone 4.6
Adalimumab 4.5
Kollidon 4.4
lactose 4.4
Aloe 4.3
Lupron 4.3
Omalizumab 4.3
Olmesartan 4.2
IL-11 4.2
Spiegel 4.1
Pirfenidone 4.1
Ginger 4.1
Fructose 4.1
Miltefosine 4.1
Raloxifene 4.0
TAK 4.0
OIF 4.0
more...
Enzyme
chymotrypsin C 6.3
lactase 5.9
tryptophan hydroxylase 5.8
thiopurine methyltransferase 5.7
CYP8B1 5.4
zeaxanthin epoxidase 5.3
tryptase 5.0
sucrase-isomaltase 4.8
inosine triphosphatase 4.7
VOR 4.6
BBE 4.6
inulinase 4.6
kynurenine aminotransferase 4.5
inulinase 4.5
guanylate cyclase 4.5
kynurenine 3-monooxygenase 4.4
kynureninase 4.4
cathepsin S 4.0
SOR 4.0
transglutaminase 4.0
sucrase 3.9
fumarylacetoacetate hydrolase 3.8
myosin light chain kinase 3.7
dimethylarginine dimethylaminohydrolase 3.7
monoacylglycerol lipase 3.5
fructokinase 3.4
MCS 3.4
legumain 3.4
NPL 3.1
O-GlcNAc transferase 3.0
dihydroorotate dehydrogenase 3.0
dihydroorotate dehydrogenase 3.0
prolyl hydroxylase 2.7
LPL 2.5
invertase 2.5
E-2 2.5
indoleamine 2,3-dioxygenase 2.5
SOR 2.5
isoamylase 2.4
TMT 2.3
diamine oxidase 2.3
alpha-glucosidase 2.2
CYP3A4 2.1
TdT 2.1
cystathionine beta-synthase 2.0
MIP 2.0
CYP7A1 2.0
SCS 2.0
angiotensin-converting enzyme 2 2.0
caspase-1 1.9
glucoamylase 1.9
trypsin 1.8
hexosaminidase 1.7
peroxidase 1.7
TSA 1.7
S1 nuclease 1.7
chymase 1.6
CAD 1.4
CAD 1.4
AST 1.4
CAD 1.4
PAL 1.3
alpha-galactosidase 1.2
cathepsin G 1.1
NOS 1.1
cathepsin K 1.1
enolase 1.1
arginase 1.1
PAM 1.1
botulinum neurotoxin 1.1
neutrophil elastase 1.0
cathepsin B 0.9
AMPK 0.9
methylenetetrahydrofolate reductase 0.9
methylenetetrahydrofolate reductase 0.9
pepsin 0.9
phosphoglycerate kinase 0.9
soluble epoxide hydrolase 0.8
citrate synthase 0.8
elastase 0.8
more...
Compound
Alverine citrate 11.0
Lubiprostone 10.6
Mebeverine hydrochloride 10.4
Dyclonine 10.4
Sennoside 9.8
Dyclonine 9.6
Tropin 9.1
5-amino-2-hydroxybenzoic acid 9.0
CC 2 8.8
4,5,6,7-tetrahydro-1H-benzimidazole 8.6
Iodoquinol 8.5
Loperamide 8.3
Diphenoxylate 8.1
3-methoxy-17-methylmorphinan 8.1
1-phenyl-1,2,3,4-tetrahydroisoquinoline 8.0
1-phenyl-1,2,3,4-tetrahydroisoquinoline 8.0
ST-37 7.7
Pheniramine 7.5
m-hydroxyphenylacetic acid 7.4
Farrerol 7.4
Dicyclomine 7.4
C6H14N2 7.3
C6H14N2 7.3
Bupropion hydrochloride 7.1
SMP2 6.9
Phloroglucinol 6.8
Lentizol 6.8
Phloroglucinol 6.7
Bismuth subsalicylate 6.7
Morphiceptin 6.6
Cisapride 6.6
Salicin 6.5
Salicin 6.5
6-Thioguanine 6.5
6-Mercaptopurine 6.5
Rifapentine 6.3
1-azabicyclo[2.2.2]oct-3-yl 6.3
3,4,5-trimethoxybenzoic acid 6.2
Ondansetron 6.1
Beclomethasone 6.1
2-methoxybenzamide 6.1
Lactulose 6.0
DSS 5.9
octyl acetate 5.8
Adenine arabinoside 5.7
PNB 5.7
Sulfasalazine 5.7
Zingerone 5.7
Menthol 5.6
cyclohexanecarboxamide 5.6
chelidonine 5.6
indole-3-acetaldehyde 5.6
Azoxymethane 5.5
Menthol 5.5
Corticotropin 5.5
Granisetron 5.4
cholest-4-en-3-one 5.4
Mesalamine 5.4
Phenylhydrazine 5.3
Nefazodone 5.3
Oridonin 5.3
Doxepin 5.3
Stevioside 5.2
Stevioside 5.2
Domperidone 5.1
Lactose 5.1
Allergan 5.0
Leuprolide 5.0
1,4-butanediamine 5.0
5-HT 4.9
NOP 4.9
BON 4.9
Pantoprazole 4.9
NCD 4.8
Deoxycholic acid 4.8
C 5 4.8
Octreotide 4.8
ANCA 4.8
Tropisetron 4.8
Azathioprine 4.8
more...