Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
8,033 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IBD 1729
gut 1406
Sep 517
TNF 185
cytokine 180
Mol 138
5-hydroxytryptamine 104
IL-6 84
5-HT3 receptor 82
mast cell 79
corticotropin-releasing factor 78
HT3 74
IL-10 72
substance P 69
tumor necrosis factor 67
cholecystokinin 56
lymphoid 50
myeloperoxidase 50
IgA 47
5-HT4 47
guanylate cyclase 45
TNF-alpha 44
IL-8 43
CD4 40
IFN 40
opioid receptor 40
IL-17 38
DSS 38
IgE 38
5-HT4 receptor 34
somatostatin 32
lactase 32
C-reactive protein 31
beta-endorphin 31
serotonin transporter 31
insulin 31
serotonin receptor 29
interferon 29
She 28
IL-23 27
more...
Disease
irritable bowel syndrome 8033
inflammatory bowel disease 2299
Crohn's disease 802
ulcerative colitis 747
colitis 493
depression 476
dyspepsia 449
gastrointestinal disease 365
celiac disease 287
cancer 279
fibromyalgia 262
gastroesophageal reflux disease 166
chronic pain 159
malabsorption 153
obesity 151
diabetes 148
colorectal cancer 147
enteropathy 126
organic disease 124
migraine 122
gastroenteritis 113
Colitis 106
asthma 106
chronic fatigue syndrome 103
diverticular disease 100
peptic ulcer 91
rheumatoid arthritis 87
psychological distress 77
interstitial cystitis 77
chronic disease 71
anxiety disorders 70
tumor 69
colon cancer 68
arthritis 67
lactose intolerance 63
Best 62
endometriosis 59
infectious diseases 58
gluten sensitivity 57
food allergy 56
more...
Symptom
diarrhea 1397
pain 1227
abdominal pain 1069
constipation 983
bloating 371
discomfort 269
discomfort 262
fatigue 169
chronic constipation 141
nausea 129
headache 128
vomiting 104
Wind 98
abdominal discomfort 92
pelvic pain 76
nausea and vomiting 47
heartburn 47
chest pain 46
analgesia 38
Gastrointestinal symptoms 38
epigastric pain 35
colic 31
back pain 29
Visceral pain 25
insomnia 25
belching 23
anorexia 23
myalgia 23
low back pain 21
anesthesia 18
spasm 18
arthralgia 18
bladder pain 18
Chronic pelvic pain 17
alexithymia 16
rectal pain 15
weakness 14
Functional abdominal pain 14
Chronic abdominal pain 13
overweight 13
more...
Drug
lactose 89
Bifidobacterium 62
Tegaserod 51
Alosetron 46
Tegaserod 45
Rifaximin 33
IL-2 19
Infliximab 17
Infliximab 17
IFN-gamma 17
caffeine 14
Dermatol 13
CSF 11
Lactose 10
Monit 8
Asthma 8
Fructose 8
Cisapride 8
CFS 7
Peppermint oil 7
lysine 7
Mesalazine 6
Aloe 6
Histamine 6
Budesonide 6
Cilansetron 6
Indomethacin 5
ROC 5
Renzapride 5
ascorbate 5
IL-11 5
Diphenhydramine 4
Portal 4
Domperidone 4
Polycarbophil 4
MAP 4
Lactase 4
TAK 4
Peppermint 4
Menthol 4
more...
Enzyme
peroxidase 55
guanylate cyclase 47
trypsin 38
lactase 32
mitogen-activated protein kinase 31
ERK 30
tryptophan hydroxylase 24
tryptase 23
transglutaminase 19
superoxide dismutase 16
protein kinase 16
catalase 14
focal adhesion kinase 13
ACS 10
sucrase 9
myosin light chain kinase 9
luciferase 8
glutathione peroxidase 8
CYP3A4 7
protein kinase C 7
reverse transcriptase 7
thiopurine methyltransferase 7
invertase 7
alkaline phosphatase 7
aspartate aminotransferase 7
lysozyme 6
thrombin 6
caspase-3 6
caspase-1 6
lactate dehydrogenase 6
sucrase-isomaltase 6
acetylcholinesterase 5
alpha-glucosidase 5
P-glycoprotein 5
NO synthase 5
MIP 5
cholinesterase 5
alanine aminotransferase 5
monoamine oxidase 4
pepsin 4
more...
Compound
Clin 901
Dec 511
5-HT 244
water 210
TNF 185
DNA 120
hydrogen 109
sodium 105
calcium 105
bromide 61
sulfate 59
glucose 53
acetic acid 52
oxygen 50
methane 40
DSS 39
barium 36
salt 33
tryptophan 33
tryptophan 31
nitric oxide 31
tryptophan 31
tryptophan 31
phosphate 29
iron 27
acetate 27
ethanol 26
vitamin D 25
Loperamide 24
ATP 23
ASA 22
arginine 19
serine 19
potassium 18
noradrenaline 18
Lubiprostone 18
DSM 17
nitrogen 16
Melatonin 16
glutamate 15
more...