Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IBD 1729
gut 1406
Sep 517
TNF 185
cytokine 180
Mol 138
5-hydroxytryptamine 104
IL-6 84
5-HT3 receptor 82
mast cell 79
corticotropin-releasing factor 78
HT3 74
IL-10 72
substance P 69
tumor necrosis factor 67
cholecystokinin 56
myeloperoxidase 50
lymphoid 50
IgA 47
5-HT4 47
guanylate cyclase 45
TNF-alpha 44
IL-8 43
CD4 40
opioid receptor 40
IFN 40
IgE 38
IL-17 38
DSS 38
5-HT4 receptor 34
somatostatin 32
lactase 32
C-reactive protein 31
serotonin transporter 31
insulin 31
beta-endorphin 31
serotonin receptor 29
interferon 29
She 28
IL-23 27
VP2 26
lipopolysaccharide 25
proton pump 25
TLR4 25
COX-2 25
NOD2 24
Pol 23
ATP 23
reserved 22
tryptophan hydroxylase 22
motilin 22
occludin 22
Cytokine 22
LPS 21
CRP 21
MRI 21
ASA 20
TRPV1 20
collagen 20
HLA 20
lactoferrin 20
inducible nitric oxide synthase 20
IL-2 19
IL-4 19
albumin 18
calcium channel 18
mucin 18
MAPK 18
chloride channel 18
IFN-gamma 17
amylase 17
uroguanylin 17
ankylosing spondylitis 17
glucagon 17
interleukin-6 16
ZO-1 16
brain-derived neurotrophic factor 16
IL-18 15
CD8 15
IL-13 14
hemoglobin 14
NK2 14
cytochrome P450 14
SERT 14
STAT3 14
CRC 14
tissue transglutaminase 14
ERK 14
San 13
gastrin 13
ANOVA 13
Gen 13
chemokine 13
CCK 13
nerve growth factor 13
SARS 13
interferon-gamma 13
glucocorticoid receptor 13
ST3 13
farnesoid X receptor 12
p38 12
nitric oxide synthase 12
histone 12
TLR2 12
CRF1 12
calcitonin 12
5-HTTLPR 11
CD25 11
P2X 11
PBS 11
c-fos 11
chromogranin A 11
ST1 11
interleukin-10 11
CRF 11
TPH1 11
p65 11
adhesion molecule 11
5-HT receptor 11
VIP 11
IL-1 11
IL-5 10
G protein-coupled receptor 10
catalase 10
CARD15 10
TGR5 10
PAR-2 10
transient receptor potential vanilloid 1 10
superoxide dismutase 10
ACS 10
NK1 10
granulocyte 10
SCL 10
thymus 10
endoplasmic reticulum 10
polypeptide 10
serum albumin 10
TCR 9
CIP 9
CRF2 9
caspase-3 9
HLA-B27 9
NLRP3 9
Pseudomonas 9
cystic fibrosis transmembrane conductance regulator 9
Janus kinase 9
human leukocyte antigen 9
ICAM-1 9
ESR 9
CD14 9
HEK 9
DLT 9
claudin-2 8
ACC 8
GM-CSF 8
adrenocorticotropic hormone 8
p40 8
MHC 8
GABA 8
IL10 8
more...
Disease
irritable bowel syndrome 8033
inflammatory bowel disease 2299
Crohn's disease 802
ulcerative colitis 747
colitis 493
depression 476
dyspepsia 449
gastrointestinal disease 365
celiac disease 287
cancer 279
fibromyalgia 262
gastroesophageal reflux disease 166
chronic pain 159
malabsorption 153
obesity 151
diabetes 148
colorectal cancer 147
enteropathy 126
organic disease 124
migraine 122
gastroenteritis 113
Colitis 106
asthma 106
chronic fatigue syndrome 103
diverticular disease 100
peptic ulcer 91
rheumatoid arthritis 87
psychological distress 77
interstitial cystitis 77
chronic disease 71
anxiety disorders 70
tumor 69
colon cancer 68
arthritis 67
lactose intolerance 63
Best 62
endometriosis 59
infectious diseases 58
gluten sensitivity 57
food allergy 56
gastroparesis 53
hypertension 53
ischemic colitis 52
mental illness 52
functional diarrhea 49
gastritis 48
psychological stress 47
major depressive disorder 46
pancreatitis 45
anemia 44
cold 42
osteoporosis 40
carcinoma 40
atopic dermatitis 40
diverticulitis 39
Inflammatory Bowel Disease 39
psoriasis 38
Clostridium difficile infection 38
DSS 38
DSS 38
cirrhosis 37
autism 37
gastrointestinal infection 37
gallstones 37
fecal incontinence 37
malnutrition 36
dysplasia 36
posttraumatic stress disorder 34
enteritis 34
multiple sclerosis 34
primary sclerosing cholangitis 33
ileus 33
Functional dyspepsia 33
necrotizing enterocolitis 33
type 2 diabetes 33
metabolic syndrome 32
Colon 32
panic disorder 32
HIV 31
Colon 31
incontinence 31
Colon 31
chronic pancreatitis 30
sexual abuse 30
lymphoma 30
Parkinson's disease 30
esophagitis 30
sleep disturbances 30
neuroticism 30
Helicobacter pylori infection 29
duodenal ulcer 29
acute diarrhea 29
cardiovascular disease 29
systemic lupus erythematosus 27
enterocolitis 27
infectious gastroenteritis 27
liver disease 27
autoimmune disease 25
carcinogenesis 25
cognitive impairment 25
immunodeficiency 24
giardiasis 24
schizophrenia 23
hepatic encephalopathy 23
incontinence 22
SEM 21
epilepsy 21
Infection 21
ischemia 21
West 21
dysphagia 20
psychosomatic disorders 20
ankylosing spondylitis 20
type 1 diabetes 20
Alzheimer's disease 20
Infectious bursal disease 19
urticaria 19
tuberculosis 19
achalasia 19
bowel obstruction 19
appendicitis 18
cystic fibrosis 18
emotional stress 18
sleep disorders 18
acute pancreatitis 18
AIDS 17
sepsis 17
sepsis 17
Syndrome 17
osteoarthritis 17
eczema 17
tension headache 17
chronic renal failure 16
aerophagia 16
atherosclerosis 16
chronic obstructive pulmonary disease 16
adenoma 16
duodenitis 15
Shigella 15
steatorrhea 15
psychosis 15
neuropathy 15
gastrointestinal dysfunction 15
fatty liver 14
infertility 14
alcoholism 14
arthropathy 14
Crohn's colitis 14
mastocytosis 14
uveitis 14
chronic hepatitis 14
pruritus 14
SARS 14
influenza 14
Newcastle disease 14
adenocarcinoma 14
tumorigenesis 13
cystitis 13
abdominal migraine 13
ileitis 13
more...
Symptom
diarrhea 1397
pain 1227
abdominal pain 1069
constipation 983
bloating 371
discomfort 269
discomfort 262
fatigue 169
chronic constipation 141
nausea 129
headache 128
vomiting 104
Wind 98
abdominal discomfort 92
pelvic pain 76
nausea and vomiting 47
heartburn 47
chest pain 46
analgesia 38
Gastrointestinal symptoms 38
epigastric pain 35
colic 31
back pain 29
insomnia 25
Visceral pain 25
belching 23
anorexia 23
myalgia 23
low back pain 21
arthralgia 18
bladder pain 18
spasm 18
anesthesia 18
Chronic pelvic pain 17
alexithymia 16
rectal pain 15
Functional abdominal pain 14
weakness 14
Chronic abdominal pain 13
overweight 13
acute stress 11
change in stool 11
stigma 10
generalized pain 10
dizziness 10
paresthesia 9
abdominal cramps 9
Ill 8
seizures 8
tinnitus 7
regurgitation 7
ataxia 7
cough 7
numbness 7
urinary frequency 7
acute pain 6
stomach pain 6
lethargy 6
sleepiness 6
intestinal pain 6
vestibulitis 6
chronic cough 5
flushing 5
dry eye 5
cachexia 5
Functional constipation 5
chills 5
hepatomegaly 5
erythema 5
GI pain 5
incoordination 5
menopausal symptoms 5
dyschezia 5
enuresis 4
tremor 4
asthenia 4
vertigo 4
distraction 4
thinning 4
acid regurgitation 4
spasticity 4
renal colic 4
chronic back pain 4
Food intolerance 4
tenesmus 4
hyperemesis 4
dyspnea 4
sore throat 3
acute abdominal pain 3
halitosis 3
Pain symptoms 3
exhaustion 3
ENT 3
neck pain 3
Depressive symptoms 3
shortness of breath 3
cancer pain 3
splenomegaly 3
exertional dyspnea 3
hyperemesis gravidarum 3
change in bowel movements 3
hunger 3
dystonia 3
syncope 3
dysuria 3
right upper quadrant pain 2
facial pain 2
generalized abdominal pain 2
loin pain 2
collapse 2
Watery diarrhea 2
acidity 2
tingling 2
atypical chest pain 2
Multimorbidity 2
sneezing 2
Joint hypermobility 2
lassitude 2
Poor sleep 2
microbial colonization 2
rhinorrhea 2
intestinal bleeding 2
Spastic 2
angina 2
gastrointestinal gas 2
hopelessness 2
dysorexia 1
Chronic pelvic pain syndrome 1
dental pain 1
abdominal fullness 1
blurred vision 1
mental fatigue 1
tonic-clonic seizure 1
respiratory distress 1
memory loss 1
disturbed balance 1
Musculoskeletal symptoms 1
Severe diarrhea 1
Cramping 1
hyperacusis 1
pachyonychia 1
hemoptysis 1
myoclonus 1
right lower quadrant pain 1
consciousness disturbance 1
blepharospasm 1
hepatosplenomegaly 1
wheezing 1
left lower quadrant pain 1
hypocapnia 1
orofacial pain 1
situational stress 1
muscle stiffness 1
agitation 1
giddiness 1
night sweats 1
Other chronic pain 1
epigastric distress 1
Vulvodynia 1
Mucosal hyperplasia 1
more...
Drug
lactose 89
Bifidobacterium 62
Tegaserod 51
Alosetron 46
Tegaserod 45
Rifaximin 33
IL-2 19
Infliximab 17
IFN-gamma 17
Infliximab 17
caffeine 14
Dermatol 13
CSF 11
Lactose 10
Fructose 8
Asthma 8
Monit 8
Cisapride 8
Peppermint oil 7
lysine 7
CFS 7
Mesalazine 6
Histamine 6
Aloe 6
Budesonide 6
Cilansetron 6
Renzapride 5
IL-11 5
ROC 5
ascorbate 5
Indomethacin 5
Lactase 4
Domperidone 4
Peppermint 4
Polycarbophil 4
Portal 4
MAP 4
TAK 4
Menthol 4
Diphenhydramine 4
EPI 3
IL-1ra 3
Trimebutine maleate 3
Prednisolone 3
Raloxifene 3
Pregabalin 3
Check 3
CAM 3
Giardiasis 3
Amitiza 3
Leaf 3
ADR 3
Calcium polycarbophil 3
ROS 3
Adalimumab 3
Nephron 3
Diurnal 3
ENT 3
Alosetron hydrochloride 2
Vitamin B12 2
Glucagon 2
Crofelemer 2
Ginger 2
Loxiglumide 2
Colesevelam 2
Asn 2
Clonidine 2
NADH 2
G-CSF 2
Estrogens 2
Ezlopitant 2
EE2 2
ACT 2
ABC 2
Prifinium bromide 2
Isotretinoin 2
Sulphasalazine 2
Omalizumab 2
ampicillin 2
Darifenacin 2
Cardiovasc 2
Gastro 2
vitamin E 2
Mosapride citrate 2
Retinoic acid 2
p75 2
ICI 2
Hypaque 2
Gabapentin 1
Kytril 1
Dextropropoxyphene 1
Kollidon 1
CDP 1
Belladonna 1
Salbutamol 1
CED 1
Senna 1
CaCl2 1
Myricetin 1
Nitazoxanide 1
Merbentyl 1
Plaquenil 1
Fosamax 1
Posture 1
Duloxetine 1
CCL 1
Lomotil 1
Amiloride 1
Methylprednisolone 1
ALA 1
Palonosetron hydrochloride 1
Questran 1
Nitric Oxide 1
Olmesartan 1
Pemetrexed 1
Hypaque 1
Caraway oil 1
CTT 1
Rapamune 1
Kenyan 1
Sulpiride 1
Scopolamine 1
Zoladex 1
Mutagen 1
Sucralfate 1
Misoprostol 1
Triad 1
Amiloride 1
Zoladex 1
AIC 1
MDS 1
Imodium 1
Acacia 1
TAT 1
Pirfenidone 1
CaCl2 1
Tacrolimus 1
niacin 1
Lovastatin 1
Anakinra 1
Atropine 1
Glide 1
EPA 1
Android 1
Allergen 1
Kytril 1
Miltefosine 1
GHRP 1
OIF 1
Arsenic trioxide 1
Riboflavin 1
Catapres 1
Spiegel 1
Imodium 1
Dextran sulfate sodium 1
Gel 1
Visilizumab 1
DPA 1
CIA 1
citric acid 1
more...
Enzyme
peroxidase 55
guanylate cyclase 47
trypsin 38
lactase 32
mitogen-activated protein kinase 31
ERK 30
tryptophan hydroxylase 24
tryptase 23
transglutaminase 19
superoxide dismutase 16
protein kinase 16
catalase 14
focal adhesion kinase 13
ACS 10
myosin light chain kinase 9
sucrase 9
glutathione peroxidase 8
luciferase 8
aspartate aminotransferase 7
thiopurine methyltransferase 7
protein kinase C 7
invertase 7
CYP3A4 7
alkaline phosphatase 7
reverse transcriptase 7
lactate dehydrogenase 6
thrombin 6
caspase-1 6
sucrase-isomaltase 6
caspase-3 6
lysozyme 6
P-glycoprotein 5
alpha-glucosidase 5
MIP 5
NO synthase 5
cholinesterase 5
acetylcholinesterase 5
alanine aminotransferase 5
APC 4
elastase 4
NOS 4
calcineurin 4
AST 4
AMP-activated protein kinase 4
lipase 4
RNA polymerase 4
pepsin 4
monoamine oxidase 4
MAP 3
AMPK 3
hexosaminidase 3
urease 3
prolyl hydroxylase 3
CAD 3
CAD 3
diamine oxidase 3
ATPase 3
AMPK 3
MEK 3
adenylate cyclase 3
urease 3
S1 nuclease 3
phospholipase C 3
CAD 3
TdT 2
NADPH oxidase 2
VOR 2
thymidine kinase 2
cathepsin B 2
glyceraldehyde-3-phosphate dehydrogenase 2
citrate synthase 2
inulinase 2
glucoamylase 2
MCS 2
proteasome 2
indoleamine 2,3-dioxygenase 2
monoacylglycerol lipase 2
neutrophil elastase 2
plasmin 2
ACE 2
NADPH oxidase 2
lipoxygenase 2
inulinase 2
xanthine oxidase 2
glucose-6-phosphate dehydrogenase 2
LPL 2
enolase 2
arginase 2
cathepsin S 2
transcriptase 2
phosphatidylinositol 3-kinase 1
glyceraldehyde-3-phosphate dehydrogenase 1
soluble epoxide hydrolase 1
peroxiredoxin 1
neuraminidase 1
kallikrein 1
phosphoenolpyruvate carboxykinase 1
TSA 1
angiotensin-converting enzyme 2 1
phosphoinositide 3-kinase 1
adenosine deaminase 1
methylenetetrahydrofolate reductase 1
alpha-galactosidase 1
CD13 1
chymase 1
phosphoenolpyruvate carboxykinase 1
glyceraldehyde-3-phosphate dehydrogenase 1
zeaxanthin epoxidase 1
PAL 1
aldehyde dehydrogenase 1
MDR 1
alpha-amylase 1
beta-galactosidase 1
glyceraldehyde-3-phosphate dehydrogenase 1
aldehyde dehydrogenase 1
inosine triphosphatase 1
cathepsin K 1
N-acetyltransferase 1
TMT 1
dihydroorotate dehydrogenase 1
isoamylase 1
SOR 1
CYP7A1 1
renin 1
DNA methyltransferase 1
dihydroorotate dehydrogenase 1
cystathionine beta-synthase 1
phosphoglycerate kinase 1
phosphoenolpyruvate carboxykinase 1
TAT 1
deaminase 1
kynurenine aminotransferase 1
SOR 1
beta-glucuronidase 1
aldehyde dehydrogenase 1
PAM 1
creatine kinase 1
tissue plasminogen activator 1
PKG 1
SCS 1
E-2 1
fumarylacetoacetate hydrolase 1
NPL 1
kynureninase 1
methylenetetrahydrofolate reductase 1
aldehyde dehydrogenase 1
glucose-6-phosphatase 1
kynurenine 3-monooxygenase 1
O-GlcNAc transferase 1
phosphodiesterase 1
CD10 1
granzyme B 1
chymotrypsin C 1
phospholipase A2 1
DNase 1
PDE 1
cdc2 1
MMP-3 1
cathepsin G 1
glyceraldehyde-3-phosphate dehydrogenase 1
more...
Compound
Clin 901
Dec 511
5-HT 244
water 210
TNF 185
DNA 120
hydrogen 109
sodium 105
calcium 105
bromide 61
sulfate 59
glucose 53
acetic acid 52
oxygen 50
methane 40
DSS 39
barium 36
tryptophan 33
salt 33
tryptophan 31
tryptophan 31
nitric oxide 31
tryptophan 31
phosphate 29
iron 27
acetate 27
ethanol 26
vitamin D 25
Loperamide 24
ATP 23
ASA 22
serine 19
arginine 19
noradrenaline 18
Lubiprostone 18
potassium 18
DSM 17
nitrogen 16
Melatonin 16
zinc 15
glutamate 15
caffeine 14
H2S 14
PEG 14
ANCA 13
cAMP 12
selenium 12
xylose 12
ammonium 12
Curcumin 11
Pac 11
tyrosine 11
NIDA 11
CO2 11
ACS 10
Ondansetron 10
cysteine 10
ACS 10
5-hydroxytryptophan 10
butyric acid 10
Lactose 10
6-Mercaptopurine 9
benzamide 9
acetonitrile 9
Optimal 9
galactose 9
Salix 9
methionine 9
glutamine 9
GABA 8
Vitamin D 8
GABA 8
Cisapride 8
ACTH 8
PGE2 8
Fructose 8
cGMP 7
Dopamine 7
His 7
Methotrexate 7
Octreotide 7
SPF 7
leucine 7
Azathioprine 7
SDS 7
Histamine 6
Estrogen 6
alanine 6
TOF 6
BMC 6
ACh 6
Luminal 6
Sulfasalazine 6
iodine 6
butyric acid 6
BMD 6
butyric acid 6
lysine 6
MMC 5
aspartic acid 5
isopropanol 5
Substance P 5
PGE 5
GMP 5
PEG 5
creatinine 5
Trypsin 5
GSH 5
Berberine 5
THP 5
ammonia 5
Estrogen 5
proline 5
Cyclosporine 5
GSH 5
Corticotropin 5
CAM 4
A 3 4
carbonate 4
CAT 4
formaldehyde 4
DMSO 4
phosphorus 4
H2S 4
EDTA 4
THP 4
nicotinamide 4
Abbott 4
Lactulose 4
MAP 4
benzene 4
HCl 4
Allergan 4
methylhistamine 4
Indomethacin 4
hydroxyindoleacetic acid 4
propionic acid 4
CAT 4
Menthol 4
CAT 4
ADR 4
threonine 4
Adenosine 4
CBS 4
Chitosan 4
5-HIAA 4
Menthol 4
Phe 4
titanium 4
COX 4
Capsaicin 4
EDTA 4
propionic acid 4
Serine 4
Diphenhydramine 4
ethyl acetate 4
Collagen 3
Prednisolone 3
salicylic acid 3
Cortisol 3
more...