Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The lesson learned from the studies on oxygen-derived free radicals and several well recognized metabolic and morphologic disturbances associated with IBD and intestinal ischaemia strongly suggests that oxyradicals can be an important mediators of colonic injury in UC. Instead of summarizing of what has been said, a schematic illustration of different pathogenetic factors which can way a vicious circle of destruction is proposed. Unfortunately, a new and specific therapy of UC is as yet not available, because the locus of primary lesion is poorly understood. It is, however, reasonable to search for a complex therapy which could break a chain of pathological processes at several subunits functioning in either positive or negative feed-back loops. In my belief, complementary treatment with free-radical scavengers is to be tested as a new and potentially efficacious modality. In this respect, preliminary encouraging results obtained with local administration of SOD encapsulated in liposomes deserve attention.
Mater Med Pol
PMID:The role of reactive oxygen metabolites in the pathogenesis of ulcerative colitis: a speculative synthesis. 248 39

Scoring systems for assessment of clinical activity of IBD were used to evaluate 62 children with IBD (14 with CD, 35 with CU and 13 with CNS). The PCDAI system was most effective in children with CD. In children with CU, both modified Truelove-Witts and Rachmilewitz indexes are equally effective, however use of the Truelove-Witts scale is simpler. The Rachmilewitz scale is better in distinguishing between UC and CNS.
Pediatr Pol 1995 Jul
PMID:[Evaluation of nonspecific inflammatory bowel disease in children using disease activity scoring systems]. 864 55

The aim of this study was to estimate the influence wheat bran enriched diet on incidence of duodenogastric reflux and symptoms in patients suffering from irritable bowel syndrome with predominant constipation. Duodenogastric reflux was examined in 31 patients by means of the cholangioscintigraphy. The results of this investigation were compared with the symptom score before and after 12 weeks of treatment with wheat bran. The incidence of duodenogastric reflux was not decreased post bran consumption. Bowel dysfunction symptom score was significantly lower in both subgroups-with and without duodenogastric reflux. However dyspeptic symptom score was not significantly lower in these groups.
Pol Merkur Lekarski 1998 Apr
PMID:[Duodenogastric reflux in patients with irritable bowel syndrome treated with wheat bran]. 977 Sep 95

Exaggerated cytokines productions and development of systemic inflammatory response (SIRS) is the most common cause of postoperative complications and death after major abdominal surgery. The present study was conducted to investigate alterations in systemic production of interleukin-6 (IL-6) and interleukin-8 (IL-8) after total parenteral nutrition (TPN) in surgical patients. Plasma concentrations of IL-6 and IL-8 were measured in 22 patients (10 treated with TPN and 12 without TPN) before major surgery and on the days 1, 3, 7, 10 and 14-16 after, by ELISA test (indications for surgery: stomach, pancreatic and colon carcinoma, complications of IBD and acute pancreatitis). There were no differences between preoperative levels of IL-6 and IL-8 in the examined groups of patients. The highest (on the days 1, 3, 7, 10: 268.3 (p = 0.002), 41.9 (p = 0.03), 122.6 (p = 0.009), 29.3 (p = 0.03) pg/ml respectively) and longer lasting significantly elevated level of IL-6 was observed in the group of patients after major surgery without TPN. In the group of patients received TPN (with glutamine) there was a significantly increased but in comparison with group of patients without TPN, significantly lower level of IL-6 on days 1 and 7 (103.4 and 34.7 pg/ml respectively, p = 0.01). There was no significant change in postoperative concentration of IL-8 after major surgery in the group of patients treated with TPN. The level of IL-8 was significantly elevated (p = 0.01) in the group of patients without TPN on day 1 and 3 following surgery. The IL-8 level in the TPN group vs. group of patients without TPN was significantly lower on day 1 after surgery. After TPN concentration of cholesterol was significantly higher and CRP level significantly lower. We conclude that TPN improved immunological response to major surgical trauma by reduction of the inflammatory response.
Pol Merkur Lekarski 2002 Jan
PMID:[Dynamic of IL-6 and IL-8 concentrations in patients after surgery treated with total parenteral nutrition]. 1195 2

The authors have evaluated the quality of life of 120 persons in three equal groups (those with irritable bowel syndrome, those with neurosis but no psychosomatic symptoms and healthy individuals). The Scale of Quality of Life constructed on the basis of the Rotterdam Symptom List, was applied. The authors have also observed the changes that took place in the noted quality of life in the course of therapy. The major conclusion that arises from this study is the following: in the case of irritable bowel syndrome, psychotherapy should be used besides typical pharmacological treatment.
Psychiatr Pol
PMID:[Quality of life in patients with irritable bowel syndrome]. 1264 57

In this paper the ecological aspects of widespread antibiotic consumption are described. Many practitioners, veterinarians, breeders, farmers and analysts work on the assumption that a antibiotics undergo spontaneous degradation. It is well documented that the indiscriminate use of antibiotics has led to the water contamination, selection and dissemination of antibiotic-resistant organisms, alteration of fragile ecology of the microbial ecosystems. The damages caused by the overuse of antibiotics include hospital, waterborne and foodborne infections by resistant bacteria, enteropathy (irritable bowel syndrome, antibiotic-associated diarrhea etc.), drug hypersensitivity, biosphere alteration, human and animal growth promotion, destruction of fragile interspecific competition in microbial ecosystems etc. The consequences of heavy antibiotic use for public and environmental health are difficult to assess: utilization of antibiotics from the environment and reduction of irrational use is the highest priority issue. This purpose may be accomplished by bioremediation, use of probenecid for antibiotic dosage reduction and by adoption of hospital infections methodology for control resistance in natural ecosystems.
Acta Microbiol Pol 2003
PMID:Overuse of high stability antibiotics and its consequences in public and environmental health. 1291 23

In 12 patients aged 9 to 17 years (14.1 +/- 2.3 SD years) (11 girls, 1 boy) complaining of abdominal pain and chronic constipation, barium large bowel X-ray examination showed the following anatomical and positional abnormalities: ptosis of the transverse colon to the small pelvis was found in 11/12 patients, ptosis of the hepatic flexure of the transverse colon (2/12), ptosis of both the hepatic and lienal flexures (2/12), dolichocolon (2/12), and dolichosigma (2/12); 10 of 12 children had symptoms characteristic of irritable colon syndrome. It seems that clinical symptoms accompanying these abnormalities begin to manifest mainly in girls during adolescence because at that time the final length of the colon is established, the transit time reaches its maximal value, and the shape of the pelvis becomes characteristic for this gender. These abnormalities are rather constitutional than acquired since previously it has been reported that the vertical ptosis of the kidney(s) occurs also mainly in adolescent girls.
Pol Merkur Lekarski 2003 Jul
PMID:[Changes of the position and length of the transverse colon causing abdominal pain and chronic constipation during adolescence]. 1459 59

Chronic abdominal pain in children can be dependent from motility disorders. The aim of the work was evaluation the frequency of changes in oesophageal manometry in children with chronic abdominal pain. Manometry studies were performed in 40 children with functional abdominal pain (group A, which was divided into subgroups: A1--functional dyspepsia, A2--irritable bowel syndrome, A3--nonspecific abdominal pain), in 11 children with gastritis (group B) and in 24 children as a control (group C). Disorders of lower oesophageal sphincter (LES) function were observed in 72.5% of group A and 45.5% of group B; transient lower oesophageal sphincter relaxations (TLESR) were noticed in 13.5%. Abnormalities of body function with the features of non-specific oesophageal motility disorders were observed in 62.5% in group A and 54.5% in group B during "dry" swallows and in 47.5% and 18.2% respectively during "wet" swallows. These changes were more frequent in dyspeptic children (85.7%). Statistical differences were established among values of resting LES pressure in analysed groups (group A or B versus group C; p < 0.05). In conclusion we mentioned that in oesophageal manometry abnormalities (LES and body function) were observed in children with functional abdominal pain and with gastritis. Characteristic features can not be defined in each group.
Pol Merkur Lekarski 2004 Jan
PMID:[Motility disorders in oesophageal manometry in children with chronic abdominal pain]. 1507 18

Fibromyalgia is a fairly common syndrome characterized by chronic, widespread musculoskeletal pain, multiple "tender points", fatigue, sleep disturbance, stiffness and other symptoms such as headache, dizziness, trouble with concentration, irritable bowel syndrome, urinary urgency, depression. Fibromyalgia may occur at any age, even in childhood, is much more common in women than in men. The cause of fibromyalgia is unknown. It is difficult to diagnose because many of the symptoms are similar to symptoms of other disorders. There are no laboratory tests that can confirm a diagnosis of fibromyalgia. Average time from onset to diagnosis is 5-8 years. Treatment of fibromyalgia requires a comprehensive approach.
Pol Merkur Lekarski 2004 Jan
PMID:[Fibromyalgia syndrome--pathogenesis, diagnosis, and treatment problems]. 1507 33

Irritable bowel syndrome creates many diagnostic and treatment difficulties in a general practitioner practice as well as in a specialist practice. Etiopathogenesis of this illness still elicit some controversy. In a diagnostic process, apart from an organic basis excluding, the most important is a medical history of a patient because of the fact that a right symptoms interpretation usually allows a correct diagnosis establishment. A treatment is in its premise a symptomatic treatment, is long-lasting and based on a mutual trust between a doctor and a patient. Basic information concerning this illness is presented in this article.
Pol Merkur Lekarski 2004
PMID:[Irritable bowel syndrome--pathogenesis, management]. 1560 53


1 2 3 Next >>