Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Inflammatory bowel disease is characterized by dysregulation of the mucosal immune system resulting from impaired intestinal epithelial barrier function. Protein kinase D2 has been implicated in the regulation of immune responses. The present study was to define
PKD2
might affect murine colitis. Colitis was induced in wild-type mice (
PKD2
WT/WT
) and
PKD2
catalytic activity deficient mice (
PKD2
SSAA/SSAA
) with dextran sulfate sodium.
PKD2
SSAA
-knockin mice displayed catalytic activity deficiency and increased susceptibility to DSS-induced colitis with enhanced weight loss, colonic inflammation compared with
PKD2
WT/WT
mice. Furthermore, crucial inflammatory cytokines mRNA levels in
PKD2
SSAA
-knockin mice were higher than controls accompanied with down-regulation of ZO-1, MUC2 and intestinal barrier dysfunction. However, there were no differences in the proliferation or apoptosis of intestinal epithelial cells in
PKD2
SSAA
-knockin mice compared with wild-type controls. In addition,
PKD2
expression was repressed in patients with
IBD
compared with healthy controls. These studies suggested that activation of
PKD2
in the colonic epithelium microenvironment may contribute to protect against DSS-induced colitis through regulation of intestinal mucosal immunity and barrier function.
...
PMID:Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. 2765 2
