Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Irritable bowel syndrome
(
IBS
) is a common functional gastrointestinal (GI) disorder around world with no standard therapy. Till date, the pathophysiology of
IBS
is not clearly understood due to complexity of the disease. Current study reveals the underlying mechanism of
IBS
using systems biological approach. The complexity of
IBS
was explained by constructing protein-protein interaction (PPI) network from the text mined genes/proteins. PPI network displayed 68822 interactions from 3595 proteins.
IBS
interactome was mapped with colon tissue interactome which resulted in a sub-network containing 153 genes. Further,
MCL
algorithm was applied to sub-network to identify six major clusters. These cluster genes are involved in several pathways such as MAPK, PI3K/Akt, and NF-kappa B. The obtained clustered genes were prioritized using differentially expressed transcriptome data of 45
IBS
and 45 normal volunteers. Among the differentially expressed genes, FUS, UNC5CL and BCLAF1 were found in the clusters, suggesting that the identified clusters could play a potential role in the regulation of
IBS
. Further pathway analysis of cluster genes revealed their molecular association with
IBS
. Gene prioritization studies identified top 10 genes that can be used as candidate biomarkers for early diagnosis of
IBS
. Out of top ten genes, PRPF31 was expressed in all biofluids (serum, saliva and urine).
...
PMID:Interactome based biomarker discovery for irritable bowel syndrome-A systems biology approach. 3007 97
