Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
CUZD1
, the CUB, and zona pellucida-like domains-containing protein 1, is a newly identified antigen of pancreatic autoantibodies (PAB) giving a reticulogranular pattern in patients with inflammatory bowel diseases, and in particular Crohn's disease. The exact mechanisms by which this pancreatic antigen becomes the target of
IBD
-specific pancreatic autoantibodies are unclear. At the same time, evolving data strongly support a role for
CUZD1
in carcinogenesis. Human
CUZD1
is mapped at chromosome 10q26.13 and the loss of this region is a frequent event in various malignant tumours. mRNA overexpression of
CUZD1
has been noted in ovarian cancer and serum levels of
CUZD1
are elevated in women with ovarian cancer and patients suffering from pancreatic cancer.
CUZD1
appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. This review discusses the role of
CUZD1
in cancer and autoimmunity. We anticipate that a better understanding of the function of
CUZD1
will help us to understand how it becomes the focus of an autoimmune attack specifically targeting the intestine and its enigmatic role in carcinogenesis.
...
PMID:CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases. 2371 Feb 7
