Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Physical stressors play a crucial role in the progression of
irritable bowel syndrome
(
IBS
). Here we report a heterogeneous physical stress induced
IBS
rat model which shows depression and subsequent modulation of
IBS
by oral treatment of
thymol
. Oral administration of
Thymol
reduces the stress induced
IBS
significantly altering the stress induced gastrointestinal hypermotility, prolonged the whole gut transit time, and increased abdominal withdrawal reflex suggesting gastrointestinal hypermotility and visceral discomfort caused the onset of depression. Immunohistochemical analysis in small intestine and colon of rats shows the decreased 5-HT
3A
R expression level while
thymol
treatment normalized the 5-HT
3A
R expression in the stressed rats. Molecular docking studies showed that
thymol
competes with endogenous serotonin and an antagonist, Tropisetron and all have similar binding energies to 5-HT
3A
R. Molecular dynamics simulations revealed that
thymol
and tropisetron might have similar effects on 5-HT
3A
R. Our study suggest that
thymol
improves
IBS
symptoms through 5-HT
3A
R, could be useful for the treatment of
IBS
.
...
PMID:Oral Phyto-thymol ameliorates the stress induced IBS symptoms. 3280 97
