Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Faecal bile acid excretion and rectosigmoid myoelectrical activity were measured on three separate occasions over a 12-month period in 21 patients with the irritable colon syndrome. The results were compared with those of a group of normal subjects. Deoxycholic acid excretion was statistically significantly lower in patients with the irritable colon syndrome. In addition, these patients had a persistently high incidence of 0.03-0.06 Hz (2-4 c/m) rectosigmoid slow-wave electrical activity. These abnormal values persisted throughout the period of the study.
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PMID:Faecal bile acids and the irritable colon syndrome. 728 62

A study was performed to determine the effect of bile acid perfusion on motility in the sigmoid colon of patients with the irritable colon syndrome compared with normal subjects. Deoxycholic acid (15 mM) statistically significantly increased motility in normal subjects (control 25.0 +/- 6.4%, perfusion 71.4 +/- 7.2%, P < 0.05) but neither chenodeoxycholic acid nor cholic acid had any apparent effect. In patients with the irritable colon syndrome, however, deoxycholic acid at 5 mM concentration (control 29.8 +/- 4.2%, during perfusion 57.4 +/- 6.5%, P < 0.05) as well as at 15 mM concentration (control 19.4 +/- 5.7+, perfusion 57.8 +/- 9.6%, P < 0.05) statistically significantly increased rectosigmoid motility. Patients with the irritable colon syndrome had a high resting 0.033-0.066 Hz (2-4 c/m) electrical activity, whereas in normal subjects 0.1-0.15 Hz (6-9 c/m) activity was greater. However, there was no statistically significant alteration in either electrical rhythm during the period of bile acid perfusion. In conclusion, additional evidence is presented to suggest that deoxycholic acid is the only bile acid likely to be implicated in the motor disorder of the irritable colon syndrome.
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PMID:Effect of bile acid perfusion on colonic motor function in patients with the irritable colon syndrome. 743 3