Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Genetic factors, among which the HLA class II coding genes, are implicated in
IBD
pathogenesis. When considering the ethnic heterogeneity of the studied population and the
IBD
clinical heterogeneity, UC appears more dependent to HLA genes than CD. UC and HLA genes: HLA DR 4 gene would protect from UC. HLA DR2 gene, particularly the
DRB
1 * 1502 allele, is predisposing for more severe forms necessitating a corticotherapy, while
DRB
1 * 0301 allele is associated with less needs for surgery. CD and HLA genes: HLA DR 7 gene and the
DRB
3 * 0301 allele predispose to CD, while HLA DR 2 and DR 3 genes may be protective factors. Thus, for MC patient, the
DRB
1 * 0301/DQB*0201 haplotype might be associated with less occurrence of fistulas or severe forms requiring immunosuppressive therapy.
...
PMID:[The role of major histocompatibility complex genes in the pathogenesis of chronic inflammatory bowel diseases]. 1293 47
