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Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen patients with irritable colon syndrome were treated with a new anticholinergic drug (prifinium bromide) and with a placebo in a 6-wk, randomized, double-blind cross-over study. The drug was orally administered in a daily dose of 90 mg before meals. Three manifestations (pain, flatulence, constipation, and/or diarrhea), scored weekly, were used as assessment criteria. Mean over-all ratings showed a difference in favor of the drug, and were statistically significant. Side effects were rare and mild. We have come to the conclusion that this anticholinergic drug may be of benefit to patients with pain-predominant forms of irritable colon syndrome.
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PMID:Prifinium bromide in the treatment of the irritable colon syndrome. 3 42

The difficulty of the diagnosis of psychosomatic disorders is known to be lying in the shortage of time, the inadequate training of physicians and in the similarity of psychosomatic symptoms are compared to those of solely organic diseases. The irritable stomach-even with hyperacidity--and the irritable colon with constipation or diarrhea are among the most frequent disorders caused by psychosomatic mechanisms. The duodenal ulcer and the ulcerative colitis belong to the true somatopsychic and psychosomatic diseases. Precise organic (diagnostic) clarification and differentiated drug therapy are necessary in addition to psychotherapeutic measures.
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PMID:[Psychosomatic disorders of the gastrointestinaltract (author's transl)]. 27 Feb 57

Dietary fiber and fiber supplements are reviewed, with particular emphasis on their sources, composition and properties; physiological actions on gastrointestinal functions; and uses in gastrointestinal disease states (functional bowel disease, diverticular disease and other conditions). Adverse effects and contraindications, and the hypothesis of diet's effect on colon cancer also are discussed. Dietary fiber supplements may relieve symptoms of constipation, spastic colon, and diverticular disease; in the two latter disorders, colonic pressure relationships are altered. It is concluded that current evidence does not support other therapeutic uses for dietary fiber sonstituents, except possibly in patients with anal fissures and hemorrhoids, which can be helped by the passage of a softer stool.
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PMID:Drug therapy reviews: dietary fiber and fiber supplements in the therapy of gastrointestinal disorders. 34 84

Twenty adult Indian patients suffering from the spastic form of irritable colon, i.e. abdominal pain and constipation, were given trimebutine (Mebutin), 2-phenyl, 2-dimethylamino-n-butyl 3, 4, 5-trimethoxybenzoate. Patients were given treatment with 200 mg trimebutine three times daily, or placebo for 4 weeks, and then crossed over. In addition, stool transit times were assessed by the single stool transit time (SST) method of Cummings. Results showed a statistical improvement in abdominal pain and constipation with both trimebutine and placebo after 4 weeks, but only with trimebutine after 8 weeks. Single stool transit time was significantly reduced after trimebutine.
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PMID:A clinical trial of trimebutine (Mebutin) in spastic colon. 45 34

Although recent work has suggested that an abnormality of the 0.05 Hz (3 c/m) slow wave electrical activity exists in the distal colon of patients with the irritable colon syndrome, it is not established whether this is related to altered bowel habit alone, or whether it is specific to the irritable colon syndrome. We have therefore studied 10 patients referred with this disorder and compared their colonic myoelectrical pattern with 10 patients suffering from assorted disorders with similar symptoms--for example, chronic pancreatitis, diverticular disease, ulcerative colitis, etc. Transit time, stool weights, percentage motility, and slow wave electrical activity were measured in each patient. The two groups were well matched for age and patients with similar symptoms in the two groups had similar values for transit time and percentage motility. There was a statistically significant increase in the 3 c/m electrical activity in patients with the irritable colon syndrome unrelated to the degree of diarrhoea or constipation. It would appear, therefore, that the abnormally high incidence of 3 c/m electrical activity in the colon is specific to the irritable colon syndrome and not merely a feature of altered bowel habit.
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PMID:Is there a myoelectrical abnormality in the irritable colon syndrome? 65 69

It has long been recognized that fruit, vegetables, and cereal fiber alter bowel function. The right colon can be regarded as a fermenter and an absorbing organ, and the left colon is for continence. A rationale for the use of fiber based on physical chemical properties is discussed. On this basis, the use of coarse wheat bran, apples, oranges, and carrots is recommended to treat diverticular disease, spastic colon, and constipation.
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PMID:Fiber in the gastrointestinal tract. 70 91

The irritable bowel syndrome (IBS) is characterized by abdominal pain and/or altered bowel habit in the absence of detectable organic bowel disease. By convention, people with simple constipation are not usually included in this group of patients. IBS is a symptom-complex with many synonyms such as irritable colon, functional bowel disorder, nervous diarrhoea or spastic colon.
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PMID:The recognition and treatment of the irritable bowel syndrome. 71 52

Psychosomatic studies of adolescent patients were conducted at the Kyushu University Hospital. Among many adolescent psychosomatic disorders, the incidence of irritable colon syndrome ranked first. The dynamic mechanisms and therapeutic results of these patients were introduced. Next, an epidemiological study showed that the frequency of constipation and diarrhea rapidly increases over the period from junior high school to senior high school. Through matched pair studies conducted with high school students, significant interrelationships were proven to exist among the occurrence of diarrhea and constipation, awareness of illness and psychological factors.
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PMID:Psychosomatic studies of Japanese youth under social changes. An overview. 74 Aug 49

The irritable colon syndrome comprises two predominant symptom patterns -- "spastic colon" with pain and constipation, and painless "nervous diarrhea". The two patterns frequently overlap. Low intake of dietary fibre is common to patients in both groups. Diagnosis of the irritable colon as a cause of diarrhea requires the characteristic symptom pattern and exclusion of organic disease. Management is based on common sense, careful reassurance of the patient, detailed explanation of the symptom pattern and explicit dietary advice. Increasing fibre in the diet is of prime importance in most patients.
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PMID:Symposium on diarrhea. 4. Diarrhea in the irritable colon syndrome. 84 55

Colonic intraluminal pressure and intestinal transit were examined in diverticular disease, idiopathic constipation, and the irritable colon syndrome. Small bowel transit was normal. Total gastrointestinal transit was prolonged. Colonic transit showed an equal delay in all segments, expedited by bran. In constipation, transit was the more prolonged, but in the irritable colon syndrome, pressure was more affected. Diverticular disease patients showed features resembling each of these two groups. Pressure and transit showed an inverse relationship maintained after bran.
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PMID:Colonic propulsion in diverticular disease, idiopathic constipation, and the irritable colon syndrome. 86 96


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