Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine
BTN
and
BTNL
genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human
BTN
and
BTNL
genes was analyzed in samples from patients with ulcerative colitis,
irritable bowel syndrome
, and colon tumors. Expression of murine
Btn
and
Btnl
genes was examined in mouse models of spontaneous colitis (
Muc2
-/-
) and intestinal tumorigenesis (
Apc
Min/+
). Our analysis indicates a strong association of several of the human genes with ulcerative colitis and colon cancer; while especially
BTN1A1
,
BTN2A2
,
BTN3A3
, and
BTNL8
were significantly altered in inflammation, colonic tumors exhibited significantly decreased levels of
BTNL2
,
BTNL3
,
BTNL8
, and
BTNL9
as compared to unaffected tissue. Colonic inflammation in
Muc2
-/-
mice significantly down-regulated the expression of particularly
Btnl1
,
Btnl4
, and
Btnl6
mRNA, and intestinal polyps derived from
Apc
Min/+
mice displayed altered levels of
Btn1a1
,
Btn2a2
, and
Btnl1
transcripts. Thus, our data present an association of
BTN
and
BTNL
genes with intestinal inflammation and cancer and represent a valuable resource for further studies of this gene family.
...
PMID:Altered expression of Butyrophilin (
BTN
) and BTN-like (
BTNL
) genes in intestinal inflammation and colon cancer. 2795 27
