Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Twin studies have traditionally been used to assess the heritability of diseases such as
irritable bowel syndrome
(
IBS
) by comparing concordance rates in monozygotic twins (identical genetic endowment) to dizygotic twins (half of genes shared). Wojczynski et al. used twins in a novel way-they studied monozygotic twins who were discordant for
IBS
(but who shared identical genes) to show that the comorbidity of
IBS
with major depressive disorder could
NOT
be due to genetic influences. This paradigm provides the most rigorous method for separating genetic from environmental influences and should be adopted by other researchers. However, the authors' conclusion that major depressive disorder and
IBS
are part of the same pathophysiological process is questioned on the basis of (a) incomplete co-occurrence of
IBS
and major depressive disorder (13-45% co-occurrence) and (b) lack of specificity-the authors show that chronic widespread pain (related to fibromyalgia) and chronic fatigue are also strongly associated with
IBS
. This study provides precise, generalizable estimates from a large population-based study for the comorbidity of
IBS
with major depressive disorder, chronic widespread pain, and chronic fatigue.
...
PMID:Twin studies used to prove that the comorbidity of major depressive disorder with IBS is NOT influenced by heredity. 1789 37
