Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present paper attempts to place the clinical use of clonidine in gynecology in a broadened perspective against the most recent advances in neuropsychopharmacology. From this review emerges the concept that clonidine, by means of its action in the central nervous system, probably affects mechanisms of crucial significance in psychosomatic symptomatology, involving the balance between attention to the external versus the internal environment. Since brain NE systems such as the one originating in the LC influence or reach vast regions of the CNS and not only cardiovascular centres, any malfunction of the LC system, whether induced by, for example, drug addiction or hormonal factors, will affect a number of functions of the individual, particularly responses to stress, and, as we understand, cardiovascular and vegetative reactivity. At present we can hypothesize that a damping or, perhaps, stabilization of the responsiveness of brain NE systems may be a fundamental mechanism of action of clonidine in this regard. As a consequence of this discussion the use of clonidine in other disorders with a clear psychosomatic component, such as the irritable bowel syndrome as well as premenstrual tension, appear to be quite interesting future avenues to explore.
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PMID:Clonidine treatment in vegetative dysfunction--experimental rationales. 386 Oct 64

We have observed a high frequency of chronic Candida albicans infection and of allergic sensitization to candida among patients with normocalcemic latent tetany (LT). Among 50 LT patients, 34% suffered from recurrent or chronic candida infection by history, 24% showed evidence of active infection and 48% demonstrated type I hypersensitivity to C. albicans extract on intradermal testing. Treatment with oral antifungal drugs and allergy desensitization to Candida produced complete relief of symptoms in 44% of the patients, with remission occurring for symptoms of depression, irritable bowel syndrome, fatigue, premenstrual tension, headache, anxiety and back pain. The complex relationship between candidiasis and Mg deficit is discussed. Patients with LT, refractory symptoms and a history of prolonged antibiotic exposure or recurrent candida infection should be considered for oral antifungal therapy and candida desensitization.
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PMID:Normocalcemic tetany and candidiasis. 391 83