Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022104 (
irritable bowel syndrome
)
8,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
RUNX3
was recently found to be associated with ulcerative colitis. In this study, downstream target genes of
RUNX3
were identified by chromatin immunoprecipitation and promoter sequence microarray chips. Polymorphisms of
RUNX3
and its 2 putative downstream (OCTN1 and PPAR-gamma) target genes were genotyped by PCR-SSP and sequencing in 144 Chinese UC patients and 151 healthy controls. Expression of
RUNX3
in colonic mucosa of UC patients was detected by immunohistochemical staining. Twelve genes involved in
IBD
were identified as the downstream target genes of
RUNX3
. The
RUNX3
rs2236851 CT genotype was associated significantly with UC susceptibility and risk of early onset in Chinese population. No association of OCTN1 and PPAR-gamma with UC susceptibility or subphenotypes was identified.
RUNX3
expression was significantly increased in UC mucosa. Therefore,
RUNX3
might be involved in UC pathogenesis by regulating the expression of genes related with immune response.
...
PMID:Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population. 2039 73
