Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Extraintestinal manifestations of ulcerative colitis and Crohn's disease are well described in the literature. These may be diagnosed before, concomitantly or after the diagnosis of the specific type of inflammatory bowel disease. Between 25% and 36% of patients with either type of IBD will have at least one extraintestinal manifestation. Pericarditis and myocarditis are rare, but potentially serious complications. We report one such case.
 ...
PMID:[Pericarditis and inflammatory bowel disease]. 971 48

Although cardiovascular complications such as Aortic syndrome (Takayasu's aortitis), Pericarditis and Myopericarditis might not be common, these complications should be noted as one of the fatal manifestation of IBD. It can be the sole or one of the several extraintestinal manifestation of either ulcerative colitis or Crohn's disease. Because of the therapeutic implications, we reviewed the literature documenting cardiovascular complication associated with ulcerative colitis. The comparatively high prevalence of Takayasu's aortitis with ulcerative colitis in Japanese patients may be explained by a immune genetic influence. HLA-B52 and DR2, were highly expressed in the patient with both disease. Myopericarditis and Pleuropericarditis associated with IBD were divided into two groups by pathogenesis, 1) drug (5-ASA)-induced disease, and 2) autoimmune disease. The cardiovascular symptom may occur while the patient's gastrointestinal disease is quiescent.
 ...
PMID:[Cardio vascular disease associated with ulcerative colitis]. 1057 27