Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is assumed, although not proven, that 13CO2-excretion following ingestion of 13C-octanoic acid (13C-OA) does not only depend on gastric emptying (GE) but also on absorption and metabolism of 13C-OA and endogenous CO2-production. Our aims were (i) to test the effects of patient characteristics and of diseases that may impair 13C-OA-metabolism on GE parameters. (ii) To compare different GE endpoints. Therefore, we investigated effects of age, gender, BMI and diseases with potential impact on 13C-OA-metabolism (including pancreatic, liver and lung disease, diabetes, IBD) on cumulative 4h-13CO2-excretion (4h-CUM) and T1/2 calculated by non-linear regression model (NL, determined by shape of breath test curve) and generalized linear regression model (GLR, reflects absolute 13CO2-excretion) in 1279 patients and 19 healthy controls who underwent a standardized 13C-OA-breath test. Digestive and metabolic disturbances hardly influenced 4h-CUM or T1/2 calculated by NL or GLR models. In the multivariate linear regression models, 4h-CUM was significantly predicted by diabetes adjusted for age, gender and IBD but influence of these parameters was small (R2 = 0.028, P < 0.0001). T1/2(NL) and 4h-CUM were weakly correlated, even after exclusion of tests with unrealistically high estimates for T1/2(NL) (n = 1095, R(2) = 0.029, P < 0.0001). Conversely, 4h-CUM was closely associated with T(1/2)(GLR) (exponential correlation, R(2) = 0.774, P < 0.00001, n = 1279). We conclude that influences of digestive and metabolic disturbances on 13CO2-excretion following 13C-OA-application are generally low. Thus, our findings resolve an important criticism of methods using absolute 13CO2-excretion for evaluation of 13C-OA-breath tests and suggest that such models may correctly identify T1/2 in a mixed patient population.
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PMID:Influence of clinical parameters on the results of 13C-octanoic acid breath tests: examination of different mathematical models in a large patient cohort. 1954 36

In opposition to opinions of a sectorialization of psychiatric illness, phenomena of comorbidity due to susceptibility of psychiatric patients to contract other diseases--whose co-presence is difficult to translate and treat--are more and more evident. In this review we have marked main issues of internal medicine in psychiatric patients. This review will discuss particularly main cardiovascular diseases (CAD, VTE), lung diseases (COPD,asthma, restrictive lung disease) gastroenterologic disease (IBS, coeliac disease, ulcerous rectocolitis), diabetes and metabolic syndrome, more likely infections verified in these patients (HIV, viral hepatitis), cancers considerably underlined (breast cancer, colon-rectal cancer and lung cancer), internistic issues in alcohol abuse which is a frequent state in these subjects. A special chapter is dedicated to antipsychotics. These drugs are characterized by a complex action modality and by frequent interactions with a large number of other drugs.
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PMID:Issues of internal medicine in psychiatric patients. 2104 55