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Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The leucocyte migration agarose technique (LMAT) was applied in a study of the migration of peripheral leucocytes in 16 patients with ulcerative colitis using three different autologous types of tissue as antigen: rectal mucosa, skin and buccal mucosa. In all cases the migration indices were within normal limits, and they did not differ from a group of control patients suffering from peptic ulcer, irritable colon or haemorrhoidal tumours. The present study does not support the theory of cellular hypersensitivity against colonic mucosa in patients with ulcerative colitis.
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PMID:Leucocyte migration test with autologous colonic mucosa as antigen in patients with ulcerative colitis. 60 54

Persons with the irritable bowel syndrome (IBS) have a significantly higher prevalence of globus and migraine-like headache than age-matched control subjects. On the other hand, persons with organic disease of the esophagus or colon may have a reduced prevalence of functional symptoms involving the opposite end of the gastrointestinal tract. The dispersed pattern of symptoms in IBS suggests that some agent, such as a hormone, may be acting systemically.
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PMID:Globus and headache: common symptoms of the irritable bowel syndrome. 63 Apr 98

Although recent work has suggested that an abnormality of the 0.05 Hz (3 c/m) slow wave electrical activity exists in the distal colon of patients with the irritable colon syndrome, it is not established whether this is related to altered bowel habit alone, or whether it is specific to the irritable colon syndrome. We have therefore studied 10 patients referred with this disorder and compared their colonic myoelectrical pattern with 10 patients suffering from assorted disorders with similar symptoms--for example, chronic pancreatitis, diverticular disease, ulcerative colitis, etc. Transit time, stool weights, percentage motility, and slow wave electrical activity were measured in each patient. The two groups were well matched for age and patients with similar symptoms in the two groups had similar values for transit time and percentage motility. There was a statistically significant increase in the 3 c/m electrical activity in patients with the irritable colon syndrome unrelated to the degree of diarrhoea or constipation. It would appear, therefore, that the abnormally high incidence of 3 c/m electrical activity in the colon is specific to the irritable colon syndrome and not merely a feature of altered bowel habit.
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PMID:Is there a myoelectrical abnormality in the irritable colon syndrome? 65 69

Functional disroders are the most important cause for complaints in the gastrointestinal tract. Dysfunction may concern one or more physiologic properties like tonus, motility, secretion, sometimes also resorption and digestion, or their interaction. Functional disorders of the esophagus (esophagospasm and achalasia) become manifest as dysphagia. Halitosis, bad taste, burning tongue, and flatulent abdomen are frequent symptoms of functional disorders of the gastrointestinal tract. Irritable bowel syndrome is probably the functional disorder most freqently found in the gastrointestinal tract. Characteristic symptoms are pain in the lower and upper middle abdominal region, obstipation and/or diarrhea, flatulent abdomen, mucous discharge with the stools and urgent defecation with cramps relieved after discharge. Prognosis quoad vitam is good, the course, however, is subject to many changes. Therapie is symptomatic. Diagnostic and psychotherapeutic measures are intended to help remove carcinophobia and to overcome conflicts and fears.
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PMID:[Functional disorders of the gastrointestinal tract (author's transl)]. 68 14

A questionnaire to establish the presence of 15 symptoms thought to be typical of the irritable bowel syndrome (IBS) was given to 109 unselected patients referred to gastroenterology or surgery clinics with abdominal pain or a change in bowel habit or both. Review of case records 17--26 months later established a definite diagnosis of IBS in 32 patients and of organic disease in 33. Four symptoms were significantly more common among patients with IBS--namely, distension, relief of pain with bowel movement, and looser and more frequent bowel movements with the onset of pain. Mucus and a sensation of incomplete evacuation were also common in these patients. The more of these symptoms that were present the more likely was it that the patient's pain or altered bowel habit, or both, was due to IBS. We conclude that a careful history can increase diagnostic confidence and reduce the amount of investigation in many patients with chronic abdominal pain.
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PMID:Towards positive diagnosis of the irritable bowel. 69 49

A double-blind clinical longterm trial with the musculotropic agent Mebeverine in 30 patients, suffering from the irritable colon syndrome, is reported. In 70% of patients, treated by this new antispasmodic preparation, most symptoms, related to the irregular activities of the lower alimentary tract--as abdominal cramps and distrubance of bowel habit--improved. Female patients were superior in getting symptom-free. No unpleasant drug-related side effects were seen. The double-blind controlled trial showed Mebeverine to be superior to a placebo preparation regarding relief of symptoms and demonstrates this agent to be a useful drug for controlling the symptoms of this functional disorder. The usefulness is enhanced by the fact that most of the patients studied had been pretreated by other preparations with low or limited therapeutic effectiveness. Despite facing the difficulties in documenting objective criteria of improvement in a condition such as the irritable colon, defined as a "collection of functional disorders of the colon of mixed aetiology" (Truelove), our results demonstrate that Mebeverine is able to improve abdominal cramps and disturbances of bowel habit in this common disorder without side effects, as seen with standard anticholinergic preparations.
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PMID:[The irritable colon syndrome. New therapeutic possibilities in the treatment of a frequent syndrome]. 70 May 92

It has long been recognized that fruit, vegetables, and cereal fiber alter bowel function. The right colon can be regarded as a fermenter and an absorbing organ, and the left colon is for continence. A rationale for the use of fiber based on physical chemical properties is discussed. On this basis, the use of coarse wheat bran, apples, oranges, and carrots is recommended to treat diverticular disease, spastic colon, and constipation.
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PMID:Fiber in the gastrointestinal tract. 70 91

Recent studies have suggested that a high incidence of 0.05 Hz (3 c/m) slow wave electrical activity is present within the rectosigmoid of patients with the irritable colon syndrome during symptomatic phases. However, it is known that this is a chronic relapsing disorder and in this study we have compared myoelectrical recordings, using an on-line frequency analyser, during periods of severe symptoms and asymptomatic phases. Treatment with either bran (in the form of bran tablets) or an antispasmodic resulted in 12 of the 20 patients becoming free from symptoms after one to three months. In those patients who were initially constipated a statistically significant increase in mean stool weight and a decrease in mean transit time occurred, but this was not associated with any alteration in either percentage motility or electrical activity. In patients with predominant diarrhoea no statistically significant difference occurred in either transit time or stool weight after treatment nor did the abnormal myoelectrical activity return towards normal with symptomatic improvement. These results suggest that a fixed basic myoelectrical abnormality exists which is unrelated to symptoms. This may help to explain the chronic relapsing nature of the irritable colon syndrome.
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PMID:Comparison of rectosigmoid myoelectrical activity in the irritable colon syndrome during relapses and remissions. 71 Sep 62

The irritable bowel syndrome (IBS) is characterized by abdominal pain and/or altered bowel habit in the absence of detectable organic bowel disease. By convention, people with simple constipation are not usually included in this group of patients. IBS is a symptom-complex with many synonyms such as irritable colon, functional bowel disorder, nervous diarrhoea or spastic colon.
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PMID:The recognition and treatment of the irritable bowel syndrome. 71 52

Psychosomatic studies of adolescent patients were conducted at the Kyushu University Hospital. Among many adolescent psychosomatic disorders, the incidence of irritable colon syndrome ranked first. The dynamic mechanisms and therapeutic results of these patients were introduced. Next, an epidemiological study showed that the frequency of constipation and diarrhea rapidly increases over the period from junior high school to senior high school. Through matched pair studies conducted with high school students, significant interrelationships were proven to exist among the occurrence of diarrhea and constipation, awareness of illness and psychological factors.
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PMID:Psychosomatic studies of Japanese youth under social changes. An overview. 74 Aug 49


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